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Cardiology Research Institute

Cardiology Research Institute is a subdivision of the Federal State Budgetary Scientific Institution “Tomsk National Research Medical Center of the Russian Academy of Sciences” (Tomsk NRMC) which is one of the largest and the most established academic institutions in Russia. Cardiology Research Institute has been a leading clinical and research institution in Siberia and Far East since it was established in the USSR over 30 years ago.

Board of Directors

  • Mr. Sergey V. Popov, MD, PhD, Professor, Member of the Russian Academy of Sciences, Director
  • Mr. Shamil D. Akhmedov, MD, PhD, Professor, Deputy Director for Innovation and Strategic Development
  • Mr. Vadim I. Lebedko, Deputy Director for Economic Development
  • Mr. Vyachaslav V. Ryabov, MD, PhD, Professor, Deputy Director for Research and Clinical Services
  • Mrs. Alla A. Boshchenko, MD, PhD, Professor, Deputy Director for Research and Clinical Services
  • Mrs. Lyubov M. Sokolnikova, Lawyer
  • Mrs. Irina Yu. Efimova, Academic Secretary

Departments of Cardiology Research Institute

  • Department of Cardiac Emergency
  • Department of Atherosclerosis and Chronic Ischemic Heart Disease
  • Department of Arterial Hypertension
  • Department of Heart Failure
  • Department of Pediatric Cardiology
  • Department of Cardiac Rehabilitation
  • Department of Cardiovascular Surgery
  • Department of Functional and Ultrasound Diagnostics
  • Department of Outpatient and Preventive Cardiology
  • Department of Population-Based Cardiology Studies with the Group of Medical Research Information, Patenting, and International Relations
  • Department of Cardiac Pacing and Heart Arrhythmia Surgical Treatment
  • Department of Diagnostic Radiology and Tomography
  • Radionuclide Diagnostic Laboratory
  • Department of Experimental Cardiology
  • Department of Molecular and Cellular Pathology and Gene Diagnostics
  • Clinical Diagnostic Laboratory

Employees of Cardiology Research Institute

Cardiology Research Institute has a unique team of accomplished professionals with high integrity, competence, heritage, and dedication contributing to cardiac science and care. Over 1000 specialists are currently working in the Cardiology Research Institute. 40,000 visitors receive specialized help from highly skilled cardiologists in the outpatient facilities of Cardiology Research Institute annually

Clinic of Cardiology Research Institute

Designed for accommodation of 430 patients, the Clinic of Cardiology Research Institute provides medical counseling, diagnostics, and treatment for residents of Siberia, Far East, and Russia’s neighboring states. High tech medical help is covered by the federal budget. 10,000 patients receive specialized inpatient cardiac care annually. About 2,000 surgical interventions with cardiopulmonary bypass are performed annually. The Clinic is involved in:

  • High tech medical treatments for patients with heart and blood vessel disorders.
  • Development and implementation of new diagnostic and treatment modalities for atherosclerosis, coronary artery disease, acute myocardial infarction, arterial hypertension, and heart failure.
  • Development of innovation approaches for reconstructive surgery of the heart and great vessels.
  • Treatment of heart rhythm disorders in children and adults.
The Clinic has excellent laboratory facilities including state-of-the-art MRI and CT imaging, radionuclide imaging systems, advanced ultrasonic equipment, ECG machines, modern angiographic complexes, and other equipment for diagnosis of cardiovascular diseases.
Except heart transplantation, all types of cardiac surgery can be performed here.
Being among a few medical centers in Russia, the Clinic successfully performs surgeries of the complex congenital heart defects in infants. Endovascular treatment of congenital heart defects is now possible in little patients starting from the age of ne week. Being among the first in the country, the specialists of Cardiology Research Institute deliver surgery for correction of transposition of the great vessels in neonates.
The Clinic has accumulated unique research and clinical data on cardiac pacing combined with cellular cardiomyoplasty. The first in the world, open heart surgery for maze procedure with radiofrequency atrial fragmentation combined with the correction of congenital and acquired heart diseases was performed here.
The Supervision Service for Healthсare and Social Development approved implementation of dozens of novel medical technologies such as endovascular closure of patent ductus arteriosus, cardioverter defibrillator implantation, catheter ablation, direct myocardial revascularization (coronary by-pass surgery), and ventricular aneurysm resection.

Science in Cardiology Research Institute

Cardiology Research Institute is a state-of-the-art research center representing all major trends of cardiovascular and interdisciplinary research. Research projects:

  • Population-based cardiology studies including World Health Organization-based program Acute Myocardial Infarction Registry
  • Development of nanocomposites for the treatment of atherosclerosis
  • Mechanisms and clinical efficacy of intracardiac radiofrequency ablation in atrial fibrillation treatment
  • Development of new criteria for prediction of cardiac synchronization therapy efficacy
  • Development of new radiopharmaceuticals
  • Development of new MRI contrast agents
  • Revascularization in patients with acute myocardial infarction
  • Autologous bone marrow cell transplantation in myocardial infarction patients
  • Radiofrequency ablation of renal arteries for the treatment of drug-resistant hypertension
  • New approaches for transesophageal and transthoracic echocardiography of the major coronary arteries and coronary reserve and classification of the echomorphology stages in thoracic aorta atherosclerosis
  • Comprehensive clinical assessment and balanced pharmacological treatment of the target organs in patients with type 2 diabetes
  • Circadian profiles of blood pressure in patients with early stages of hypertensive encephalopathy
  • Predictors for hypertensive encephalopathy and stroke
  • New methods of neuroprotection in patients with arterial hypertension
  • Pathophysiological characteristics of the pulmonary and coronary microcirculation and transcapillary oxygen exchange in coronary artery disease complicated by left ventricular failure
  • Immunomodulation strategy in myocardial infarction patients with chronic heart failure
  • Genetic factors contributing to triggering and progression of heart failure in patients with coronary artery disease
  • Prevention and treatment of heart failure in patients undergoing cardiac surgery
  • Experimental cell-free blood vessel matrix engineering
  • Hybrid cardiac surgery approaches combining cell technologies for treatment of dilated cardiomyopathy
  • Reserve capacity of the pulmonary microcirculation in patients with myocardial infarction, congenital and acquired heart diseases
  • The role of cerebral perfusion abnormalities in pathogenesis of neurocognitive dysfunction associated with cardiovascular diseases
  • Cardioprotective potential of cannabinoid and opioid receptor modulators
International Collaborative Projects of Cardiology Research Institute
  • The molecular mechanisms of chronic hypoxia-induced adaptation (China).
  • The development of a new pharmaceutical agent based on opioid peptide derivate improving adaptation capabilities of the organism (China).
  • The role of receptor transactivation in the mechanisms of cardioprotective effects of cannabinoids in heart reperfusion (Israel).
  • The role of opioid receptors, cannabinoid receptors, protein kinase C, tyrosine kinase, mitochondrial permeability transition pore, and mitochondrial and sarcolemmal KATP-channels in the mechanisms of cardioprotective adaptation to chronic normobaric hypoxia (Czech Republic).
  • Studies investigating co-morbidities aggravating heart failure (Germany, UK, Italy, Poland, and Slovenia).
  • The development of new nanoparticle-based technology for treatment of atherosclerosis (Germany).

Our team is currently looking for 2017-2021 cooperation in the following research directions:

  1. Biomedical support of high performance sport. Studying the risk factors and methods for prevention of sudden cardiac death in elite athletes and in young sports players.
  2. Developing and testing the nanoparticle-based drug-eluting vascular stents for the treatment of atherosclerosis.
  3. Testing and marketing the ECG-EXPRESS telecardiology device.
  4. Studying the clinical and morphological characteristics of chronic inflammation in the myocardium of patients with decompensated heart failure and ischemic systolic dysfunction. The study will test the hypothesis that the presence of inflammatory reaction heterogeneity in cardiac tissue is associated with inefficacy of anti-inflammatory and neurohumoral treatment strategies aimed at preventing decompensation of chronic heart failure syndrome in coronary artery disease patients who underwent revascularization procedure.
  5. Studying the neuroprotective and cardioprotective properties of stress-activated JNK inhibitors and TRP channel modulators.
  6. Elucidating the cellular and molecular mechanisms of abnormal platelet hemostasis in patients with diabetes mellitus type 2 comorbid with arterial hypertension. The project will aim at evaluating the effects of ROS, anti-inflammatory cytokines, and insulin on platelet aggregation activity in patients with diabetes mellitus type 2 comorbid with arterial hypertension. Comprehensive evaluation of platelet hemostasis will allow for determination of the role of intracellular signaling systems in the mechanisms of abnormal platelet aggregation activity in these patients.
  7. Studying genetic polymorphisms associated with the risk of thrombophilia in acute coronary syndrome in patients with nonobstructive coronary artery disease. The project will determine significance of genetic polymorphisms linked to the risk f thrombophilia in these patients.
  8. Studying the effects of carbohydrate metabolism and cardiotropic viruses persistence on monocyte/macrophage polarization during reparative regeneration after myocardial infarction.
  9. Pilot clinical study for evaluation of the efficacy and safety of immunomodulation therapy of chronic virus-positive inflammatory cardiomyopathy.
  10. Evaluating the efficacy of six-month course of replacement therapy with interferon (Viferon®) in patients with chronic virus-positive inflammatory cardiomyopathy.
  11. Regeneration technologies for compensation of cardiomyocyte loss due to myocardial infarction.
  12. Search for laboratory markers or multi-biomarkers predicting atherosclerotic plaque erosion or haemorrhage leading to atherothrombosis.
  13. Engineering cardiac pacemaker cell line for heart regeneration. Objectives of the project: (1) improvement/optimization of the method for reprogramming human fibroblasts into the pluripotent stem cells (pPSC); (2) generation of pacemaker cells from pPSC; and (3) noninvasive imaging study of pacemaker cells implanted into rat heart.
  14. Studying the role of serotonergic innervation in contractile and electrical functions of the smooth muscle cells. The project will test the hypothesis that serotonergic nervous system is a previously unrecognized branch of autonomic nervous system along with sympathetic and parasympathetic branches. The hypothesis is based on the discovery of abundant serotonergic nervous fibers in the sympathetic trunk in experimental animals.
  15. Conventional and unconventional cardiovascular risk factors in women of working age: incidence, associations, prognostic significance, and prevention.
  16. Development of new radiopharmaceuticals for cardiac diagnostics: labeled antibiotics and fatty acids.
  17. Development of new and improvement of existing methods of cardiovascular imaging.
  18. Development of novel cardiac protection and preconditioning techniques.