Anton A. Fedorov
Junior Researcher, Laboratory of Cancer Progression Biology Cancer Research Institute, Tomsk NRMC
Contact details
e-mail: anton.fedorov.2014@mail.ru
tel.: 8 (3822) 28-26-76, add 3376
Brief Biography
Work experience:
September 2019-Present: Junior Researcher, Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk National Research Medical Center
Education:
2013-2019: MD student, Department of Biochemistry and Molecular Biology, Siberian State Medical University.
2019-2022: PhD student, Laboratory of Molecular Oncology and Immunology, Cancer Research Institute, Tomsk NRMC
Research Interests
The study of phenotypic differences between peripheral blood monocytes and in vitro induced macrophages in patients with non-small cell lung cancer depending on pre-tumor changes in the respiratory epithelium of the bronchi. Search for genotypic determinants of the risk of metastasis and recurrence of non-small cell lung cancer.
Functional changes of immune cells in blood and tumor microenvironment of breast cancer patients under chemotherapy.
Grants
Anton Fedorov actively involved in the implementation of grants as an executor: RFBR «The relationship of the phenotypic profile of monocyte-macrophage lineage cells with the risk of progression of non-small cell lung cancer in patients with various types of pre-tumor changes in the respiratory epithelium» (2020-2022 № 20-315-90055); RSF "Genetic determinants of distant metastasis in non-small cell lung carcinoma" (2020-2022, № 20-75-10060); RSF "New technology for prediction and prevention of distant metastasis based on detection of circulating metastasis-initiating and niche-forming cells and their specific targets" (2019-2022, №19-75-30016); RSF "Molecular landscape of oral cancer in young adult patients" (2022-2024, №22-15-00308); RSF "Functional portrait of immune cells as a factor of breast cancer chemotherapy efficacy" (2022-2025, №22-75-10128) (at the moment).
Publications
1. T. Gerashchenko, A. Frolova, M. Patysheva, A. Fedorov, M. Stakheyeva, E. Denisov. Breast Cancer Immune Landscape: Interplay Between Systemic and Local Immunity //Advanced Biology. – 2024. – С. 2400140. https://doi.org/10.1002/adbi.202400140
2. A. Frolova, T. Gerashchenko, M. Patysheva, A. Fedorov, V. Korobeynikov, E. Garbukov, O. Bragina, N. Cherdyntseva. Single cell transcriptomics of the immune cells during chemotherapy in triple-negative breast cancer patients. Abstracts of ESMO Congress, 20–24 October 2023, Madrid // Annals of Oncology 2023;34 (S2), 24P. https://doi.org/10.1016/j.annonc.2023.09.1527
3. Gerashchenko T.S., Patysheva M.R., Frolova A.A., Fedorov A.A., Iamshchikov P.S., Vashisth M., Bragina O.D., Garbukov E.Yu., Cherdyntseva N.V. Transcriptome changes of immune cells across chemotherapy of triple-negative breast cancer. Abstracts of ESMO Congress, 20–24 October 2023, Madrid // Annals of Oncology 2023;34 (S2), 93P. https://doi.org/10.1016/j.annonc.2023.09.1592
4. Phenotypic profile of monocyte-macrophage lineage cells as a function of respiratory epithelium status / A. Fedorov, N. Ermak, E. Topolnitskiy [et al.] // Siberian journal of oncology. – 2023. – Vol. 22. – № 4. – P. 55-64. https://doi.org/10.21294/1814-4861-2023-22-4-55-64
5. Preparation of a Single-Cell Suspension from Tumor Biopsy Samples for Single-Cell RNA Sequencing / A. A. Frolova, T. S. Gerashchenko, M. R. Patysheva [et al.] // Bulletin of Experimental Biology and Medicine. – 2023. – Vol. 175. – № 4. – P. 519-523. https://doi.org/10.1007/s10517-023-05898-9
6. Changes in blood monocyte functional profile in breast cancer / A.A. Fedorov, E.A. Prostakishina, M.R. Patysheva [et al.] // Siberian journal of oncology. – 2022. – Vol. – 21. - № 4. – P. 124-136. https://doi.org/10.21294/1814-4861-2022-21-6-68-80
7. Fedorov A.A., Ermak N.A., Gerashchenko T.S., Topolnitskii E.B., Shefer N.A., Rodionov E.O., Stakheyeva M.N. Polarization of macrophages: mechanisms, markers and factors of induction. Siberian journal of oncology. 2022;21(4):124-136. (In Russ.) https://doi.org/10.21294/1814-4861-2022-21-4-124-136
8. Prognosis of Different Types of Non-Small Cell Lung Cancer Progression: Current State and Perspectives / A. A. Schegoleva, A. A. Khozyainova, A. A. Fedorov [et al.] // Cellular Physiology and Biochemistry. – 2021. – Vol. 55. – № S2. – P. 29-48. https://doi.org/10.33594/000000340
9. Evaluation of human macrophage functional state by voltammetric monitoring of nitrite ions / V. Popova, E. Korotkova, J. Barek [et al.] // Analytical and Bioanalytical Chemistry. – 2020. – Vol. 412. – № 21. – P. 5097-5104. https://doi.org/10.1007/s00216-020-02399-w
10. Cytostatic cancer therapy modulates monocytes-macrophage cell functions: how it impact on treatment outcomes / M. Patysheva, M. Stakheyeva, I. Larionova [et al.] // Experimental Oncology. – 2019. - Vol. 41. - № 3. - P. 248-253. https://doi.org/10.32471/exp-oncology.2312-8852.vol-41-no-3.13597