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Evgeny V. Denisov

Evgeny V. Denisov

Evgeny V. Denisov, PhD, Head of the Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk NRMC.

Contact details

tel.: 8 (3822) 28-26-76 ext. 3375

Brief Biography

Work experience

2019 – Present: Head of the Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk NRMC
2015 – Present: Assistant Professor, Department of Organic Chemistry, Tomsk State University
2011 – 2019: Senior Researcher, Laboratory of Molecular Oncology and Immunology, Cancer Research Institute, Tomsk NRMC
2014-2015: Senior Researcher, Laboratory for Translational Cellular and Molecular Biomedicine, Tomsk State University
2010-2011: Probationer-Researcher, Institute of Biology and Biophysics, Tomsk State University
2009-2010: Senior Technician, Department of Cytology and Genetics, Tomsk State University
09-12.2009: Probationer-Researcher, Institute of Chemical Biology and Fundamental Medicine, SB RAS
2008-2011: Junior Researcher, Laboratory of Immunology, Cancer Research Institute, SB RAMS
2005 – 2008: Technician, Laboratory of Immunology, Cancer Research Institute, SB RAMS


2007-2010: PhD in Genetics, Tomsk State University
2005-2007: MSc in Biology, Tomsk State University
2001-2005: BSc in Biology, Tomsk State University

Research Interests

  • The premalignant process in bronchial epithelium: markers of progression or inhibition of bronchial lesions
  • Circulating tumor cells in breast cancer: genetic heterogeneity and an association with metastasis
  • Germline and somatic genetic variations involved in NSCLC metastasis and recurrence
  • Intratumor morphological heterogeneity in breast cancer as a model for studying the genetic determinants and mechanisms of tumor cell invasion


More than 20 projects have been supported by Federal Target Program of Ministry of Science and Education of the Russian Federation, Russian Foundation for Basic Research (RFBR), Russian Science Foundation (RSF), The Russian President Grants, The Foundation for Assistance to Small Innovative Enterprises in Science and Technology, and OPTEK Company. At the present time, E.V. Denisov is involved in three big projects:

  • “Molecular markers of progression/inhibition of bronchial lesions for prognosis of the premalignant process and the risk of squamous lung cancer” (RFBR, 2017-2020)

  • “Genetic alterations involved in tumor cell invasion and their role in breast cancer development” (RFBR, 2018-2021)

  • “New strategy for the prediction and prevention of distant metastasis based on the detection of circulating metastasis-initiating and niche-forming cells and their specific targets” (RSF, 2019-2022)


  1. IASLC Developing Nation Travel Award (2019)
  2. Awards of the Tomsk Region Administration (2007, 2011, 2018)
  3. The Company of Biologist Bursary (2015)
  4. EACR Meeting Bursary Awards (2012, 2014)
  5. Travel Grant funded by Susan G. Komen for the Cure (2013)
  6. Travel grant of the 12th St. Gallen Breast Cancer Conference (2011)
  7. Fellowship of the 3rd Norwegian Cancer Symposium (2011)
  8. The Russian President Fellowship (2009-2010)
  9. CIMO Fellowship (2009)
  10. The Russian Government Fellowship (2008-2009)
  11. D.I. Mendeleev Fellowship (2008-2009)
  12. The Medal of the Ministry Science and Education of the Russian Federation (2008)
  13. Tomsk Mayor Fellowship (2006-2007)


  1. Clinical Translational Research Network (2021-present).
  2. European Association for Cancer Research (2010-present).
  3. Asia-Pacific Chemical, Biological& Environmental Engineering Society (2010-present).
  4. Vavilov Society of Geneticists and Breeders (2006-present).
  5. Russian Society of Biochemistry and Molecular Biology (2010-present).
  6. International Association for the Study of Lung Cancer (2019-2020).
  7. European Society for Medical Oncology (2009-2012).


E.V. Denisov is an author of more than 190 publications (including 1 book, 2 book chapters, and 63 peer-reviewed papers), 6 Russian patents, 2 databases, and 1 know-how. 

The current list of publications: PubMed

Selected publications

  1. Novikov, N.M., Zolotaryova, S.Y., Gautreau, A.M., Denisov E.V. Mutational drivers of cancer cell migration and invasion. Br J Cancer 2021;124:102-114.
  2. Gerashchenko T.S., Zolotaryova S.Y., Kiselev A.M., Tashireva L.A., Novikov N.M., Krakhmal N.V., Cherdyntseva N.V., Zavyalova M.V., Perelmuter V.M., Denisov E.V. The Activity of KIF14, Mieap, and EZR in a New Type of the Invasive Component, Torpedo-Like Structures, Predetermines the Metastatic Potential of Breast Cancer. Cancers 2020;12:1909.
  3. Tashireva L.A., Zavyalova M.V., Savelieva O.E., Gerashchenko T.S., Kaigorodova E.V., Denisov E.V., Perelmuter V.M. Single tumor cells with epithelial-like morphology are associated with breast cancer metastasis. Frontiers in Oncology 2020;10:50.
  4. Pankova O.V., Rodionov E.O., Miller S.V., Tuzikov S.A., Tashireva L.A., Gerashchenko T.S., Denisov E.V., Perelmuter V.M. Neoadjuvant chemotherapy combined with intraoperative radiotherapy is effective to prevent recurrence in high-risk non-small cell lung cancer (NSCLC) patients. Translational Lung Cancer Research 2020;9(4):988–999.
  5. Denisov E.V., Schegoleva A.A., Gervas P.A., Ponomaryova A.A., Tashireva L.A., Boyarko V.V., Bukreeva E.B., Pankova O.V., Perelmuter V.M. Premalignant lesions of squamous cell carcinoma of the lung: The molecular make-up and factors affecting their progression. Lung Cancer 2019;135:21-28.
  6. Gerashchenko T.S, Novikov N.M, Krakhmal N.V, Zolotaryova S.Y, Zavyalova M.V, Cherdyntseva N.V, Denisov E.V, Perelmuter V.M.  Markers of Cancer Cell Invasion: Are They Good Enough? J Clin Med 2019;8(8). pii: E1092.
  7. Denisov E.V., Schegoleva A.A., Gerashchenko T.S., Skryabin N.A., Sleptcov A.A., Yakushina V.D., Lyapunova L.S., Tuzikov S.A., Pankova O.V., Perelmuter V.M. Gene expression profiling revealed 2 types of bronchial basal cell hyperplasia and squamous metaplasia with different progression potentials. AIMM 2019; doi: 10.1097/PAI.0000000000000762.
  8. Le Borgne-Rochet M., Angevin L., Bazellières E., Ordas L., Comunale F., Denisov E.V., Tashireva L.A., Perelmuter V.M., Bièche I., Vacher S., Plutoni C., Seveno M., Bodin S., Gauthier-Rouvière C. P-cadherin-induced decorin secretion is required for collagen fiber alignment and directional collective cell migration. J Cell Sci 2019;132(21):jcs233189.
  9. Molinie N., Rubtsova S.N., Fokin A., Visweshwaran S.P., Rocques N., Polesskaya A., Schnitzler A., Vacher S., Denisov E.V., Tashireva L.A., Perelmuter V.M., Cherdyntseva N.V., Bièche I., Gautreau A.M. Cortical branched actin determines cell cycle progression. Cell Res 2019;29:432-445.
  10. Planchon D., Rios Morris E., Genest M., Comunale F., Vacher S., Bièche I., Denisov E.V., Tashireva L.A., Perelmuter V.M., Linder S., Chavrier P., Bodin S., Gauthier-Rouvière C. MT1-MMP targeting to endolysosomes is mediated by upregulation of flotillins. J Cell Sci 2018;131(17):jcs218925.
  11. Denisov E.V., Perelmuter V.M. A fixed partial EMT triggers carcinogenesis, whereas asymmetrical division of hybrid EMT cells drives cancer progression. Hepatology 2018;68(3):807-810.
  12. Visweshwaran SP, Thomason PA, Guerois R, Vacher S, Denisov EV, Tashireva LA, Lomakina ME, Lazennec‐Schurdevin C, Lakisic G, Lilla S, Molinie N, Henriot V, Mechulam Y, Alexandrova AY, Cherdyntseva NV, Bièche I, Schmitt E, Insall RH, Gautreau A. The trimeric coiled‐coil HSBP1 protein promotes WASH complex assembly at centrosomes. The EMBO Journal 2018;37(13):e97706.
  13. Denisov E.V., Skryabin N.A., Gerashchenko T.S., Tashireva L.A., Wilhelm J., Buldakov M.A., Sleptcov A.A., Lebedev I.N., Vtorushin S.V., Zavyalova M.V., Cherdyntseva N.V., Perelmuter V.M. Clinically relevant morphological structures in breast cancer represent transcriptionally distinct tumor cell populations with varied degrees of epithelial-mesenchymal transition and CD44+CD24- stemness. Oncotarget 2017;8:61163-61180.
  14. Tashireva L.A., Denisov E.V., Gerashchenko T.S., Pautova D.N., Buldakov M.A., Zavyalova M.V., Kzhyshkowska J., Cherdyntseva N.V., Perelmuter V.M. Intratumoral heterogeneity of macrophages and fibroblasts in breast cancer is associated with the morphological diversity of tumor cells and contributes to lymph node metastasis. Immunobiology 2017;222:631-640.
  15. Denisov E.V., Gerashchenko T.S., Zavyalova M.V., Manskikh V.N., Choinzonov E.L., Cherdyntseva N.V., Perelmuter V.M. Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma. Hepatocellular Carcinoma, Current Clinical Oncology (Brian Carr, ed.). Springer International Publishing: Switzerland 2016, p. 211-228.
  16. Pankova O.V., Denisov E.V., Ponomaryova A.A., Gerashchenko T.S., Tuzikov S.A., Perelmuter V.M. Recurrence of squamous cell lung carcinoma is associated with the co-presence of reactive lesions in tumor-adjacent bronchial epithelium. Tumor Biology 2016;37(3):3599-3607.
  17. Krakhmal N.V., Zavyalova M.V., Denisov E.V., Vtorushin S.V., Perelmuter V.M. Cancer invasion: Patterns and mechanisms. Acta Naturae 2015;7(2):17-28.
  18. Denisov E.V., Skryabin N.A., Vasilyev S.A., Gerashchenko T.S., Lebedev I.N., Zavyalova M.V., Cherdyntseva N.V., Perelmuter V.M. Relationship between morphological and cytogenetic heterogeneity in invasive micropapillary carcinoma of the breast: a report of one case. Journal of Clinical Pathology 2015;68(9):758-762.
  19. Denisov E.V., Litviakov N.V., Zavyalova M.V., Perelmuter V.M., Vtorushin S.V., Tsyganov M.M., Gerashchenko T.S., Garbukov E.Y., Slonimskaya E.M. and Cherdyntseva N.V. Intratumoral morphological heterogeneity of breast cancer: neoadjuvant chemotherapy efficiency and multidrug resistance gene expression. Scientific Reports 2014;4:4709.
  20. Gerashchenko T.S., Denisov E.V., Litviakov N.V., Zavyalova M.V., Vtorushin S.V., Tsyganov M.M., Perelmuter V.M., Cherdyntseva N.V. Intratumor heterogeneity: nature and biological significance. Biochemistry (Mosc) 2013;78:1201–1215.