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Irina V. Larionova

Irina V. Larionova

Irina V. Larionova, PhD, Junior Researcher of the Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk NRMC, Junior Researcher of the Laboratory of Translational Cellular and Molecular Biomedicine, Tomsk State University. 

Contact details


Brief Biography

Work experience

2019 –present: Junior Researcher of the Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk NRMC

2015-present: Junior Researcher of the Laboratory of Translational Cellular and Molecular Biomedicine, Tomsk State University

2015-2019: Junior Researcher of the Laboratory of Molecular Oncology and Immunology, Cancer Research Institute, Tomsk NRMC


2009-2015: student of Siberian State Medical University

2015 – 2016: Internship in clinical laboratory diagnostic, Siberian State Medical University

2016-2019: graduate student at Cancer Research Institute

2019: Ph.D. thesis “Phenotype of tumor-associated macrophages of breast cancer and colorectal cancer in association with tumor progression and chemotherapy”

International experience

2015, 2016, 2017, 2018: Traineeship at the Institute of Transfusion Medicine and Immunology, University of Heidelberg, Mannheim, Germany.

Research Interests

Major research interests: oncology, molecular and cellular biology, immunology, breast cancer, colon cancer, macrophages, monocytes, chemotherapy, tumor progression. 


Scopus AuthorId=56862097400

ResearcherID Web of Science: R-2391-2017


Laureate of the Tomsk Region Prize in Education, Science, Healthcare and Culture (2018)

Laureate of the Legislative Duma of the Tomsk Region in the nomination "Natural Sciences" (2017) Scholarships from the President of the Russian Federation (2013-2014, 2014-2015, 2017-2018, 2018-2019), and the Government of the Russian Federation (2011-2012, 2012-2013), scholarship “City of Tomsk” (2013-2014).

Main projects

1) RSF No. 19-15-00151 “The role of monocyte programming in the development of pro- and anti-tumor phenotypes of tumor-associated macrophages and efficiency of chemotherapy in colorectal cancer” (2019-2021).

2) RFBR № 20-015-00384 “Regulation of tumor angiogenesis and metastasis by macrophages in the context of their programming by chemotherapy in colon cancer” (2020-2022).

3) Research № NU L “Search for biomarkers and therapeutic targets in the processes of chronic inflammation associated with the progression of malignant neoplasms, regenerative processes of cardiovascular diseases and implantology”, (2014-2020).

4) RFBR No. 17-29-06037 " Genomic regulation of the breast cancer progression during chemotherapy" (2017-2020).

Main publications

1.    Larionova I., E. Kazakova, M. Patysheva, J. Kzhyshkowska. Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages. Cancers (Basel). 2020 May 29;12(6):1411. doi: 10.3390/cancers12061411.

2.    Larionova I.,  G. Tuguzbaeva, A. Ponomareva,  M. Stakheeva,  N. Cherdyntseva, V. Pavlov, E. Choinzonov and  J. Kzhyshkowska. Tumor-associated macrophages in human breast, colorectal, lung, ovarian and prostate cancers. Front. Oncol. 10:566511. doi: 10.3389/fonc.2020.566511

3.    Kzhyshkowska J, Larionova I, Liu T. YKL-39 as a Potential New Target for Anti-Angiogenic Therapy in Cancer. Front Immunol. 2020 Jan 22;10:2930. doi: 10.3389/fimmu.2019.02930.

4.    Yin S, Wang N, Riabov V, Mossel DM, Larionova I, Schledzewski K, Trofimova O, Sevastyanova T, Zajakina A, Schmuttermaier C, Gratchev A, Flatley A, Kremmer E, Zavyalova M, Cherdyntseva N, Simon-Keller K, Marx A, Klüter H, Goerdt S, Kzhyshkowska J. SI-CLP inhibits the growth of mouse mammary adenocarcinoma by preventing recruitment of tumor-associated macrophages. Int J Cancer. 2020 Mar 1;146(5):1396-1408. doi: 10.1002/ijc.32685.

5.    Kzhyshkowska J, Grigoryeva, E., Larionova, I.  Targeting the Tumor-Associated Macrophages for 'Normalizing' Cancer. In: Bizzarri M, editor. Approaching Complex Diseases, Human Perspectives in Health Sciences and Technologies 2. Cham: Springer Nature Switzerland AG (2020). p. 245-74.

6.    Larionova, N. Cherdyntseva, T. Liu, M. Patysheva, M. Rakina, J. Kzhyshkowska. Interaction of tumor-associated macrophages and cancer chemotherapy. Oncoimmunology. – 2019. – V.8, № 7.

7.    Patysheva M, Stakheyeva M, Larionova I, Fedorov A, Kzhyshkowska J, Cherdyntseva N. Cytostatic cancer therapy modulates monocyte-macrophage cell functions: how it impacts on treatment outcomes. Exp Oncol. 2019 Sep;41(3):248-253. DOI: 10.32471/exp-oncology.2312-8852.vol-41-no-3.13597.

8.    T. Liu, I. Larionova, N. Litviakov, V. Riabov, M. Zavyalova, M. Tsyganov, M. Buldakov, B. Song, K. Moganti, P. Kazantseva, E. Slonimskaya, E. Kremmer, A. Flatley, H. Klüter, N. Cherdyntseva, J. Kzhyshkowska. Tumor-associated macrophages in human breast cancer produce new monocyte attracting and pro-angiogenic factor YKL-39 indicative for increased metastasis after neoadjuvant chemotherapy .  Oncoimmunology. – 2018. – V.7, № 6.

9.    E. Nikitina, I. Larionova, E. Choinzonov, J. Kzhyshkowska.  Monocytes and Macrophages as Viral Targets and Reservoirs. Int J Mol Sci. – 2018. – V. 19, № 9.

10. N. Litviakov, M. Tsyganov, I. Larionova, M. Ibragimova, I. Deryusheva, P. Kazantseva, E. Slonimskaya, I. Frolova, E. Choinzonov, N. Cherdyntseva, J. Kzhyshkowska. Expression of M2 macrophage markers YKL-39 and CCL18 in breast cancer is associated with the effect of neoadjuvant chemotherapy. Cancer Chemother. Pharmacol. – 2018. – Vol. 82, № 1. – P. 99-109.

11. Mitrofanova, M (Larionova I.), . Zavyalova, V. Ryabov, N. Cherdyntseva, J. Kzhyshkowska. The effect of neoadjuvant chemotherapy on the correlation of tumor-associated macrophages with CD31 and LYVE-1. Immunobiology. – 2018. – Vol. 223, № 6-7. – P. 449-459.

12. M. Stakheyeva, V. Riabov, I. Mitrofanova, N (Larionova I.). Litviakov, E. Choinzonov, N. Cherdyntseva, J. Kzhyshkowska. Role of the Immune Component of Tumor Microenvironment in the Efficiency of Cancer Treatment: Perspectives for the Personalized Therapy. Curr Pharm Des. – 2017. – Vol. 23, № 32. – P.  4807-4826.

13. Mitrofanova, M (Larionova I.). Zavyalova, N. Telegina, M. Buldakov, V. Riabov V, N. Cherdyntseva, J. Kzhyshkowska. Tumor-associated macrophages in human breast cancer parenchyma negatively correlate with lymphatic metastasis after neoadjuvant chemotherapy.  Immunobiology. – 2017. – Vol. 222, № 1. – P. 101-09.

14. Mitrofanova, M (Larionova I.). Zavyalova, M. Buldako, N. Cherdyntseva, J. Kzhyshkowska. Effect of neoadjuvant chemotherapy on correlation of tumor-associated macrophages with angiogenesis and lymphangiogenesis in human breast cancer. Annals of Oncology. -2017. – V. 28, №. 5.

15. Mitrofanova (Larionova I.), L. Tengfei, M. Zavyalova, N. Litviakov, M. Buldakov, N. Cherdyntseva, J. Kzhyshkowska.  YKL-39 induces monocytes migration and angiogenesis and inversely correlates with metastasis in patients with breast cancer. Annals of Oncology. -2017. – V. 28, №. 5.

16. M. Buldakov, M. Zavyalova, N. Krakhmal, N. Telegina, S. Vtorushin, I. Mitrofanova, (Larionova I.) V Riabov, S. Yin, B. Song, N. Cherdyntseva, J. Kzhyshkowska. CD68+, but not stabilin-1+ tumor associated macrophages in gaps of ductal tumor structures negatively correlate with the lymphatic metastasis in human breast cancer. Immunobiology. – 2017. - Vol. 222, № 1. – P. 31–38.

17. J. Kzhyshkowska, Mitrofanova (I. Larionova), M.Zavyalova, E. Slonimskaya, N. Cherdyntseva. Tumor-associated macrophages. M.: Nauka – 2017. – 224 с. (In Russ.)

18.  Cherdyntseva N.V., Mitrofanova I.V., Buldakov M.A., Stakheeva M.N., Patysheva M.R., Zavjalova M.V., Kzhyshkowska J.G. Macrophages and tumor progression: on the way to macrophage-specific therapy. Bulletin of Siberian Medicine. 2017;16(4):61-74. (In Russ.)

19. J. Kzhyshkowska, S. Yin, T. Liu, V. Riabov, I. Mitrofanova (Larionova I.). Role of chitinase-like proteins in cancer. Biol. Chem. – 2016. – Vol. 397, № 3. – P. 231-47.       

20. J. Kzhyshkowska, M.Stakheeva, N. Litviakov, O. Savelieva, I. Mitrofanova (I. Larionova), I. Stepanov, A. Gratchev, T. Gerchshenko, M.Zavyalova, N. Cherdyntseva. Immune system and the efficacy of cancer treatment. Tomsk - Publishing house Tomsk University – 2015.–164 p. (In Russ.).