Elena S. Kolegova
PhD, Researcher, Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk NRMC.
Contact details
e-mail: elenakolegova@oncology.tomsk.ru
тел. 8 (3822) 51-45-98
Brief CV
2014-2015: research assistant, Laboratory of Tumor Biochemistry, Tomsk Cancer Research Institute
2015-2018: PhD student, Laboratory of Tumor Biochemistry, Cancer Research Institute, Tomsk National Research Medical Center
2016-2019: Junior Researcher, Laboratory of Tumor Biochemistry, Cancer Research Institute, Tomsk National Research Medical Center
2019: successfully defended her PhD thesis.
2020-Present: Researcher, Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk National Research Medical Center
Research Interests
Elena S. Kolegova is an author of more than 60 scientific publications, including 20 articles in the journals indexed by Web of Science and Scopus database. The main scientific studies of E.S. Kolegova are related to the study of the molecular mechanisms of tumor progression; the search for markers associated with metastasis and relapse of cancer. She is engaged in the study of protein regulation in the pathogenesis of malignant neoplasms.
Achievements, awards, and grants
Elena Kolegova is the head of the RFBR grant No. 18-415-703003 r_mol_a "The role of actin-binding proteins in the formation of metastases of non-small cell lung cancer", 2018-2019. Actively involved in the implementation of grants as an executor: RFBR grant No. 13-04-00169 “Locomotor proteins and the regulation of their expression in tumors of the female reproductive system”, 2013-2015; RFBR grant No. 14-04-91150 GFEN_a “Fundamental aspects of the participation of the system of insulin-like growth factors in the development of malignant neoplasms associated with metabolic syndrome”, 2014-2015; RFBR grant No. 17-04-00198 “Actin-binding proteins: connection with the type of cell migration and neoplastic transformation of human epithelium”, 2017-2018; RFBR grant No. 17-304-50020 “Functioning of proteasomes and calpains in the tumor progression of non-small cell lung cancer”, 2017; RFBR grant No. 18-415-703006 r_mol_a “Tetraspanins and exosome proteases as prognostic factors and predictors of hematogenous metastasis in colorectal cancer”, 2018-2019.
Elena S. Kolegova co-authored three patents and two databases: “A method for determining the risk of developing distant metastases in patients with colon cancer” (No. 2623119, 2017); “A method for assessing the risk of an adverse outcome of a disease in patients with gastric cancer” (No. 2662085, 2018), “A method for predicting an adverse outcome in non-small cell lung cancer” (No. 2696872, 2019), “Database of clinical and morphological parameters and gene expression profile encoding cell motility proteins in patients with squamous cell carcinoma of the head and neck ”(No. 2019620439, 2019),“ Database of clinical and morphological parameters and indicators of intracellular proteolytic systems in patients with non-small cell lung cancer ” (No. 2019621601, 2019).
In 2014-2015, she received a scholarship from the Government of the Russian Federation among students of educational institutions of higher professional education, studying full-time, according to state-accredited educational programs that correspond to the priority areas of modernization and technological development of the Russian economy.
She is a laureate of a scholarship of the President of the Russian Federation to young scientists and graduate students (Competition SP-2018) in the framework of the topic of scientific research: Development of a technology for predicting malignant metastases of non-small cell lung cancer for 2018 - 2020.
Main Publications
1. Kolegova E. S., Kakurina G. V., Kostromitskiy D. N., Dobrodeev A. Yu., Kondakova I. V. Increases in mRNA and Protein Levels of the Genes for the Actin-binding Proteins Profilin, Fascin, and Ezrin Promote Metastasis in Non-Small Cell Lung Cancer // MOLECULAR BIOLOGY. 2020. Vol. 54(2). P. 1–15. DOI: 10.31857/S0026898420020068
2. Stakheyeva M., Eidenzon D., Slonimskaya E., Patysheva M., Bogdashin I., Kolegova E., Grigoriev E., Choinzonov E., Cherdyntseva N. Integral characteristic of the immune system state predicts breast cancer outcome // Exp. Oncol. 2019. Vol. 41(1). P. 32-38. DOI: 10.32471/exp-oncology.2312-8852.vol-41-no-1.12593
3. Tugutova E.A., Tamkovich S.N., Patysheva M.R., Afanas’ev S.G., Tsydenova A.A., Grigor’eva A.E., Kolegova E.S., Kondakova I.V., Yunusova N.V. Relation between Tetraspanin- Associated and Tetraspanin- Non- Associated Exosomal Proteases and Metabolic Syndrome in Colorectal Cancer Patients // Asian P.J. of Cancer Prevention. 2019. Vol. 20(3). P.809-815. DOI: 10.31557/APJCP.2019.20.3.809
4. Kolegova, E.S., Kakurina, G.V., Kondakova, I.V., Dobrodeev, A.Y., Kostromitskii, D.N., Zhuikova, L.D. Adenylate Cyclase-Associated Protein 1 and Cofilin in Progression of Non-Small Cell Lung Cancer // Bulletin of Experimental Biology and Medicine. 2019. Vol. 167(3). P. 393-395. DOI: 10.1007/s10517-019-04534-9
5. Kakurina, G.V., Kolegova, E.S., Cheremisina, O.V., Choinzonov, E.L. Molecular features of head and neck squamous cell carcinoma // Bulletin of Siberian Medicine. 2018. Vol. 17(3). P. 61-69. https://doi.org/10.20538/1682-0363-2018-3-61-69
6. Kakurina, G.V., Kondakova, I.V., Spirina, L.V., Kolegova, E.S., Shashova, E.E., Cheremisina, O.V., Novikov, V.A., Choinzonov, E.L. Expression of Genes Encoding Cell Motility Proteins during Progression of Head and Neck Squamous Cell Carcinoma // Bulletin of Experimental Biology and Medicine. 2018. Vol. 166(8). P. 209-212. DOI: 10.1007/s10517-018-4325-1
7. Tamkovich, S.N., Yunusova, N.V., Somov, A.K., Afanas'ev, S.G., Kakurina, G.V., Kolegova, E.S., Tugurova, E.A., Laktionov, P.P., Kondakova, I.V. Comparative sub-population analysis of exosomes from blood plasma of cancer patients // Biomeditsinskaya Khimiya. 2018. Vol. 64(1). P. 110-114. DOI: 10.18097/PBMC20186401110
8. Kakurina, G. V.; Kolegova, E. S.; Kondakova, I. V.Adenylyl Cyclase-Associated Protein 1: Structure, Regulation, and Participation in Cellular Processes // Biochemistry-Moscow. 2018. Vol.83(1). P. 45-53. DOI: 10.1134/S0006297918010066
9. Spirina, L.V., Usynin, Y.A., Yurmazov, Z.A., Slonimskaya, E.M., Kolegova, E.S., Kondakova, I.V. Transcription factors NF-kB, HIF-1, HIF-2, growth factor VEGF, VEGFR2 and carboanhydrase IX mRNA and protein level in the development of kidney cancer metastasis // MOLECULAR BIOLOGY. 2017. Vol. 51(2). P. 372-377. DOI: 10.7868/S0026898417020197
10. Kolegova, E.S., Kondakova, I.V., Zavialov, A.A. Small heat shock proteins and the ubiquitin-proteasome system in malignant tumors // Voprosy Onkologii. 2016. Vol. 62(3). P. 401-405.
11. Yunusova N.V., Spirina L.V., Frolova A.E., Afanas’ev S.G., Kolegova E.S., Kondakova I.V. Association of IGFBP-6 expression with metabolic syndrome and adiponectin and IGF-IR receptor levels in colorectal сancer // Asian P.J. of Cancer Prevention. 2016. Vol. 17. P.3963-3969. DOI: http://dx.doi.org/10.7314/APJCP.2016.17.