Personalities

Nadezhda V. Cherdyntseva

Nadezhda V. Cherdyntseva, Ph.D., D.Sc., Professor, Corresponding Member of the Russian Academy of Sciences, Deputy Director for Science of Tomsk NRMS, Head of the Department of Molecular Oncology and Immunology of Cancer Research Institute, Leading Researcher of the Laboratory for Translational Cell and Molecular Biomedicine of Tomsk State University.

Contact information

e-mail: nvch@tnimc.ru
tel.: +7 (3822) 515342

Brief Biography

Nadezhda V. Cherdyntseva graduated from Tomsk State University in 1975. In 1979 she was employed at the Tomsk Cancer Research Institute of the Russian Academy of Medical Sciences as a research fellow. In 1987, she obtained her PhD degree in Oncology and in 1999 she defended doctoral thesis for an academic degree of Doctor of Sciences. In 1992, she was appointed as a Head of the Immunology Department of Cancer Research Institute. In 2001, Nadezhda V. Cherdyntseva was awarded the rank of Professor in discipline of Oncology. In 2003, she was elected a Deputy Director for Science of Cancer Research Institute of Siberian Branch of the Russian Academy of Medical Sciences. Since 2016, Prof. Cherdyntseva has been a Deputy Director for Science of Tomsk NRMC. In July, 2016, she was elected a Corresponding Member of the Russian Academy of Sciences in discipline of Oncology. She also works at the Oncology Department of Siberian Medical University as a lecturer.

Research Interests

N.V.Cherdyntseva is one of the leading scientists in the field of molecular oncology, immunology and pathophysiology. Her current research focuses on studying the molecular mechanisms of cancer initiation and progression, as well as resistance of tumors to anticancer therapy, considering the ethnic characteristics of the population residing in the region of Siberia and the Russian Far East. N.V.Cherdyntseva initiated the consolidation of molecular genetic research in the field of oncology in SB RAMS. Under supervision of N.V. Chergyntseva, priority data on the genetic component of susceptibility to breast cancer in the region of Siberia and the Russian Far East were obtained, the frequency of genetic mutations associated with breast cancer in various Siberian ethnic groups was studied, and the lack of "slavic" mutations in representatives of the Mongoloid ethnic groups was shown. Specific mutations in the BRCA1 gene were found in Buryat breast cancer patients, thus having opportunity to identify women at high risk for breast cancer. A significant contribution of the ethnic-specific genetic variants to the efficacy and tolerability of chemotherapy was shown. In the laboratory headed by Prof. Cherdyntseva, new research areas within the concept of the importance of the deregulation of the relationship between cells and their microenvironment in the pathogenesis of cancer are intensively developing. Nadezhda V. Cherdyntseva made substantial contribution to the study of molecular mechanisms of intratumor heterogeneity, the role of clonal evolution of tumors during chemotherapy and drug resistance mechanisms. Based on chromosomal aberrations of tumor cells, the predictive markers of response to chemotherapy were developed. New mechanisms of regulation of drug resistance genes were identified and signaling pathways associated with intratumoral heterogeneity were found. Priority fundamental data opening prospects for the development of innovative approaches to personalized therapy for cancer patients were obtained. Under direct supervision of Prof. N.V. Cherdyntseva, her team has been active in the strategic direction of modern medicine: preventive, predictive and personalized oncology, takes part in the European and Russian programs to improve the molecular genetic diagnostics for personalized cancer therapy. The methods of molecular diagnostics of inherited and somatic genetic disorders were implemented into clinical practice to personalize cancer treatment. Her research interest includes a wide-range of studies initiated by Prof. N.V.Vasilev, the Member of the Russian Academy of Sciences. The immunological aspects of cancer formation and progression under conditions of genetic predisposition, aging, and adaptation to stress-inducing factors were studied, approaches to the immune system correction were developed, and the effectiveness of biological response modifiers to improve the results of cancer therapy was experimentally proved.
Nadezhda V. Cherdyntseva is an author of more than 250 scientific publications, including 10 books, 10 patients, and 115 conference contributions. Citations: 1010, H index: 14 (RINC – Russia), H index Scopus and Web of Science: 11 and 9.
Under supervision of Nadezhda V. Cherdyntseva, 4 dissertations for a degree of Doctor of Sciences and 23 dissertations for a degree of Candidate of Sciences (equivalent of Ph.D.) have been defended.
The Experimental Department headed by Prof. N.V. Cherdyntseva provides research facilities for students and postgraduate students of National Research State University and Siberian State Medical University to defend their diploma/master and PhD theses.
Being a worldwide renowned Russian oncologist, Nadezhda V. Cherdyntseva promotes achievements of her team abroad and regularly gives talks at international symposia, conferences, and meetings.
Professor N.V. Cherdyntseva actively involves in the integration of academic and university research, she is one of the organizers of the International laboratory, set up jointly by the National Research Tomsk State University, Tomsk NRMC and Heidelberg University.

Achievements, awards, and grants

Nadezhda V. Cherdyntseva is actively engaged in the training of young specialists for the city of Tomsk. She is a supervisor of the Council of Young Scientists of the Center. Under her supervision, the annual conferences gathering young oncologists from different cities of Russia and abroad are held.
Nadezhda V. Cherdyntseva is a member of the Scientific Council of Tomsk NRMC. She is Deputy Editor-in-Chief of Siberian Journal of Oncology and a member of the editorial boards of the following journals: Gynecological Oncology (Moscow), "Experimental Oncology" (Kiev), "Advances in Molecular Oncology". Prof. Cherdyntseva is a member of the European Respiratory Society (ERS), European Association for Cancer Research (EACR), European Society for Medical Oncology (ESMO) and the Russian Society of Clinical Oncology RUSSCO. She is an Expert of the Russian Science Foundation.
Research projects conducted by Prof. N.V.Cherdyntseva and her colleagues received financial support in the framework of the federal target programs of the Russian Federation, the Ministry of Health of the Russian Federation, grants of the Russian Foundation for Basic Research, the Russian Science Foundation, and the European program "ERA.Net Rus Plus".
For high achievements in scientific and educational activities, Nadezhda V. Cherdyntseva has been awarded with the government and community awards: Honorary Diplomas of Academy of Medical Sciences, Siberian Branch of the Academy of Medical Sciences, Tomsk Oblast Administration, scholarship from the Governor of Tomsk region, Achievement Medal and Commemorative Badge of the Russian Association of Oncologists for her contribution to the development of professional relationships between oncologists of CIS & Eurasian countries. She is Honorary Professor of Shenzhen Second Hospital (China). She is a Laureate of Tomsk region award in the field of Science and Healthcare.

Main Publications

1. Evgeny V. Denisov, Tatiana S. Gerashchenko, Marina V. Zavyalova, Vasiliy N. Manskikh,Evgeny L. Choinzonov, Nadezhda V. Cherdyntseva, Vladimir M. Perelmuter. Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma. Hepatocellular Carcinoma // Current Clinical Oncology / ed. Maurie Markman. - Springer International Publishing, 2016. – P. 211-228. – DOI 10.1007/978-3-319-34214-6


2. Nikolai V. Litviakov, Nadezhda V. Cherdyntseva, Matvey M. Tsyganov, Еlena М. Slonimskaya, Marina K. Ibragimova, Polina V. Kazantseva, Julia Kzhyshkowska, Eugeniy L. Choinzonov Deletions of multidrug resistance gene loci in breast cancer leads to the down-regulation of its expression and predict tumor response to neoadjuvant chemotherapy // Oncotarget, Advance Publications 2016


3. Ponomaryova A.A., Morozkin E.S., Rykova E.Y., Zaporozhchenko I.A., Skvortsova T.E., Dobrodeev А.Y., Zavyalov A.A., Tuzikov S.A. , Vlassov V.V. ,Cherdyntseva N.V., Laktionov P.P., Choinzonov E.L. Dynamic changes in circulating mirna levels in response to antitumor therapy of lung cancer // Exp Lung Res. - 2016; 42(2):95-102. doi: 10.3109/01902148.2016.1155245.


4. Babyshkina N., Vtorushin S., Zavyalova M., Patalyak S., Dronova T., Litviakov N., Slonimskaya E., Kzhyshkowska J., Cherdyntseva N., Choynzonov E. The distribution pattern of ERα expression, ESR1 genetic variation and expression of growth factor receptors: association with breast cancer prognosis in Russian patients treated with adjuvant tamoxifen // Clinical and Experimental Medicine. – 2016. - pp. 1-11. Article in Press. DOI: 10.1007/s10238-016-0428-z


5. Gainetdinov I.V., Kapitskaya K.Y., Rykova E.Y., Ponomaryova A.A., Cherdyntseva N.V., Vlassov V.V., Laktionov P.P., Azhikina T.L. Hypomethylation of human-specific family of LINE-1 retrotransposons in circulating DNA of lung cancer patients // Lung Cancer. 2016 Sep;99:127-30. doi: 10.1016/j.lungcan.2016.07.005. Epub 2016 Jul 5.


6. Mitrofanova I., Zavyalova M., Telegina N., Buldakov M., Riabov V., Cherdyntseva N., Kzhyshkowska J. Tumor-associated macrophages in human breast cancer parenchyma negatively correlate with lymphatic metastasis after neoadjuvant chemotherapy // Immunobiology. 2016 Aug 4. pii: S0171-2985(16)30342-4. doi: 10.1016/j.imbio.2016.08.001. [Epub ahead of print]


7. Gervas P., Ivanova A., Vasiliev N., Ananina O., Zharkova O., Rogovieva O., Verzhbitskaya N., Didichuk I., Cheremisina O., Popova N., Goldberg V., Cherdyntsev E., Choynzonov E., Cherdyntseva N. Frequency of EGFR Mutations in Non-small Cell Lung Cancer Patients: Screening Data from West Siberia. // Asian Pac J Cancer Prev. 2015;16(2):689-92. DOI: http://dx.doi.org/10.7314/APJCP.2015.16.2.689/


8. Denisov E.V., Gerashchenko T.S., Zavyalova M.V., Litviakov N.V., Tsyganov M.M., Kaigorodova E.V., Slonimskaya E.M., Kzhyshkowska J., Cherdyntseva N.V., Perelmuter V.M. Invasive and drug resistant expression profile of different morphological structures of breast tumors. // Neoplasma. - 2015;62(3):405-11. doi: 10.4149/neo_2015_041.


9. Grigoryeva E.S., Kokova D.A., Gratchev A.N., Cherdyntsev E.S., Buldakov M.A., Kzhyshkowska J.G., Cherdyntseva N.V. Smoking-related DNA adducts as potential diagnostic markers of lung cancer: new perspectives // Exp Oncol. 2015 Mar;37(1):5-12. http://exp-oncology.com.ua/article/7445/smoking-related-dna-adducts-as-potential-diagnostic-markers-of-lung-cancer-new-perspectives


10. Denisov E.V., Gerashchenko T.S., Cherdyntseva N.V., Zavyalova M.V., Skryabin N.A., Vasilyev S.A., Lebedev I.N., Perelmuter V.M. Relationship between morphological and cytogenetic heterogeneity in invasive micropapillary carcinoma of the breast: A report of one case // Journal of clinical pathology . – 2015. Sep;68(9):758-62. DOI: 10.1136/jclinpath-2015-203009. – http://elibrary.ru/item.asp?id=24944542


11. Elena V. Antontseva ,Marina YU. Matveeva, Natalia P. Bondar, Elena V. Kashina,Elena YU. Leberfarb, Leonid O. Bryzgalov, Polina A. Gervas, Anastasia A. Ponomareva, Nadezhda V. Cherdyntseva, Yury L. Orlov, Tatiana I. Merkulova Regulatory single nucleotide polymorphisms at the beginning of intron 2 of the human KRAS gene // Journal of Biosciences. – 2015, Dec; 40(5): P. 873-83


12. Buldakov M., Zavyalova M., Krakhmal N., Telegina N., Vtorushin S., Mitrofanova I., Riabov V., Yin S., Song B., Cherdyntseva N., Kzhyshkowska J. CD68+, but not stabilin-1+ tumor associated macrophages in gaps of ductal tumor structures negatively correlate with the lymphatic metastasis in human breast cancer // Immunobiology. 2015 Sep 8. pii: S0171-2985(15)30062-0. doi: 10.1016/j.imbio.2015.09.011. –http://elibrary.ru/item.asp?id=24950236


13. Buldakov M. A., Feril L.B. Jr, Tachibana K., Cherdyntseva N.V., Kondo T. Low-intensity pulsed ultrasound enhances cell killing induced by X-irradiation // Ultrason Sonochem. - 2014 Jan;21(1). - P. 40-2. -doi: 10.1016/j.ultsonch.2013.06.013. Epub 2013 Jun 27 - http://elibrary.ru/item.asp?id=20558335


14. Grigoryeva E.S., Cherdyntseva N.V., Karbyshev M.S., Volkomorov V.V., Stepanov I.V., Zavyalova M.V., Perelmuter V.M., Buldakov M.A., Afanasjev S.G., Tuzikov S.A., Bukurova Y.A., Lisitsyn N.A., Beresten S.F. Expression of Cyclophilin A in Gastric Adenocarcinoma Patients and Its Inverse Association with Local Relapses and Distant Metastasis // Pathol Oncol Res. 2014. - Т. 20, № 2. - С. 467-473. – http://elibrary.ru/item.asp?id=21872816


15. Denisov EV, Litviakov NV, Zavyalova MV, Perelmuter VM, Vtorushin SV, Tsyganov MM, Gerashchenko TS, Garbukov EY, Slonimskaya EM, Cherdyntseva NV. Intratumoral morphological heterogeneity of breast cancer: neoadjuvant chemotherapy efficiency and multidrug resistance gene expression // Sci Rep. 2014 Apr 16;4:4709. doi: 10.1038/srep04709. – http://elibrary.ru/item.asp?id=21872294


16. Babyshkina N., Malinovskaya E., Patalyak S., Bragina O., Tarabanovskaya N., Doroshenko A., Slonimskaya E., Perelmuter V., Cherdyntseva N. Neoadjuvant chemotherapy for different molecular breast cancer subtypes: a retrospective study in Russian population // Med Oncol. 2014 Sep;31(9):165. - doi: 10.1007/s12032-014-0165-7. – http://elibrary.ru/item.asp?id=24939520


17. Vtorushin S.V., Khristenko K.Y., Zavyalova M.V., Perelmuter V.M., Litviakov N.V., Denisov E.V., Dulesova A.Y., Cherdyntseva N.V. The phenomenon of multi-drug resistance in the treatment of malignant tumors // Exp. Oncol. – 2014. - 36, 3, 144–156. http://exp-oncology.com.ua/article/7053/the-phenomenon-of-multi-drug-resistance-in-the-treatment-of-..


18. Buldakov, M.A., Hassan, M.A., Jawaid, P., Cherdyntseva, N.V., Kondo, T. Cellular effects of low-intensity pulsed ultrasound and X-irradiation in combination in two human leukaemia cell lines // Ultrasonics Sonochemistry 2015 Mar;23:339-46. doi: 10.1016/j.ultsonch.2014.08.018. http://elibrary.ru/item.asp?id=23956985


19. Skurikhin E.G., Khmelevskaya E.S., Pershina O.V., Ermakova N.N., Krupin V.A., Reztsova A.M,, Ermolaeva L.A,, Yakushina V.D., Stepanova I.E., Reztsova V.M., Cherdyntseva N.V., Stakheeva M.N., Dygai A.M. Differentiation of mesenchymal multipotent stromal cells of the lungs in pneumofibrosis. // Bull Exp Biol Med. 2013 Feb;154(4):537-43. – http://elibrary.ru/item.asp?id=20442929


20. Zavyalova M.V., Perelmuter V.M., Vtorushin S.V., Denisov E.V., Litvyakov N.V., Slonimskaya E.M., Cherdyntseva N.V. The presence of alveolar structures in invasive ductal NOS breast carcinoma is associated with lymph node metastasis. Diagn Cytopathol. 2013 Mar;41(3):279-82. doi: 10.1002/dc.21852. – http://elibrary.ru/item.asp?id=21878192


21. Babyshkina Nataliya, Malinovskaya Elena, Nazarenko Mariya, Koval Mariya, Gervas Polina, Potapova Olga, Slonimskaya Elena, Cherdyntseva Nadejda The effect of folate-related SNPs on clinicopathological features, response to neoadjuvant treatment and survival in pre- and postmenopausal breast cancer patients // Gene. - 2013. – Vol. 518, № 2 (15 apr). - P. 397–404. http://elibrary.ru/item.asp?id=20427508


22. Volkomorov V., , Grigoryeva E., Krasnov G., Litviakov N., Tsyganov M., Karbyshev M.,Zavyalova M., Afanasуev S., Cherdyntseva N., Lisitsyn N., Beresten S. Search for potential gastric cancer markers USING miRNA databases and gene expression analysis // Exp Oncol 2013. – Vol.35. - № 1. – С.2-7.- http://exp-oncology.com.ua/article/4455/search-for-potential-gastric-cancer-markers-using-mirna-data...


23. Zavyalova Marina V., Denisov Evgeny V., Tashireva Lubov A., Gerashchenko Tatiana S., Litviakov Nikolay V., Skryabin Nikolay A., Vtorushin Sergey V., Telegina Nadezhda S.,Slonimskaya Elena M., Cherdyntseva Nadezhda V., Perelmuter Vladimir M. Phenotypic drift as a cause for intratumoral morphological heterogeneity of invasive ductal breast carcinoma not otherwise specified // BioResearch Open Access. - Volume 2, Number 2, April 2013 Mary Ann Liebert, Inc. DOI: 10.1089/biores.2012.0278. – http://elibrary.ru/item.asp?id=23317114


24. Kuligina ESh, Sokolenko AP, Mitiushkina NV, Abysheva SN, Preobrazhenskaya EV, Gorodnova TV, Yanus GA, Togo AV, Cherdyntseva NV, Bekhtereva SA, Dixon JM, Larionov AA, Kuznetsov SG, Imyanitov EN. Value of bilateral breast cancer for identification of rare recessive at-risk alleles: evidence for the role of homozygous GEN1 c.2515_2519delAAGTT mutation. // Fam Cancer. 2013 Mar;12(1):129-32. doi: 10.1007/s10689-012-9575-x. – http://elibrary.ru/item.asp?id=20428535


25. Litviakov, Nicolay V. , Cherdyntseva, Nadezhda V., Tsyganov, Matvey M. , Denisov, Evgeny V. ,Garbukov, Evgeny Y., Merzliakova, Marina K. ,Volkomorov, Victor V. ,Vtorushin, Sergey V., Zavyalova, Marina V. Slonimskaya, Elena M. ,Perelmuter, Vladimir M. Changing the expression vector of multidrug resistance genes is related to neoadjuvant chemotherapy response // Cancer Chemotherapy and Pharmacology. - 2013. – Vol.71,№ 1. – P. 153-163. – http://elibrary.ru/item.asp?id=20418739


26. Cherdyntseva Nadezda V. , Ivanova Anna A., Ivanov Vladimir V. , Evgeny Cherdyntsev, Krishnan Krishnan Nair Cherupally, Kagiya Tsutomu V. Ascorbic acid glucoside reduces neurotoxicity and glutathione depletion in mouse brain induced by nitrotriazole radiosensitazer // Journal of Cancer Research and Therapeutics: Official publication of Association of Radiation Oncologists of India (AROI) - July-September 2013 - Volume 9 - Issue 3. – P.364-369. – http://elibrary.ru/item.asp?id=21881029


27. Ponomaryova AA, Rykova EY, Cherdyntseva NV, Skvortsova TE, Dobrodeev AY, Zav'yalov AA, Bryzgalov LO, Tuzikov SA, Vlassov VV, Laktionov PP. Potentialities of aberrantly methylated circulating DNA for diagnostics and post-treatment follow-up of lung cancer patients // Lung Cancer. - 2013 Sep;81(3). – P. 397-403. – http://elibrary.ru/item.asp?id=20457710


28. Sensitivity of Some Biological Objects to Repetitive Submicrosecond Microwave Pulses / L. P. Zharkova, M. A. Buldakov, I. R. Knyazeva, O. P. Kutenkov, N.V. Litvyakov, N.V.Mamonova, N.V. Cherdyntseva, M. A. Bolshakov and V. V. Rostov // Journal of Energy and Power Engineering. – 2012. –№ 6. – C. 925-931.-


29. Rykova E. Y, Morozkin E. S., Ponomaryova A.A., Loseva E. M., Zaporozhchenko I.A., Cherdyntseva N.V, Vlassov V.V., Laktionov P.P. Cell-free and cell-bound circulating nucleic acid complexes: mechanisms of generation, concentration and content // Expert Opin Biol Ther. - 2012. - Suppl 1. - S141-53. - http://elibrary.ru/item.asp?id=17986420


30. Anastasia A. Ponomaryova, Elena Y. Rykova, Nadezhda V. Cherdyntseva, Tatiana E. Skvortsova, Anna V. Cherepanova, Evgeniy S. Morozkin, Vladislav A. Mileiko, Nikolai V. Litvjakov, Alexey Y. Dobrodeev, Alexander A. Zav’yalov, et al. Concentration and Distribution of Single-Copy β-Actin Gene and LINE-1 Repetitive Elements in Blood of Lung Cancer Patient // Circulating Nucleic Acids in Plasma and Serum 2011, Part 2, 41-45. – https://download.e-bookshelf.de/download/0000/0735/57/L-G-0000073557-0002355494.pdf


31. Cherdyntseva N. V., Denisov E. V., Litviakov N. V., Maksimov V. N. Malinovskaya E. A., Babyshkina N. N., E. M. Slonimskaya, Voevoda M. I., E. L. Choinzonov Crosstalk Between the FGFR2 and TP53 Genes in Breast Cancer: Data from an Association Study and Epistatic Interaction Analysis // DNA and Cell Biology. – DNA Cell Biol. 2012 Mar;31(3):306-16. doi: 10.1089/dna.2011.1351. Epub 2011 Aug 12. – http://elibrary.ru/item.asp?id=17979809


32. Denison E.V., Sukhanovskaya T.V., Cherdyntseva N.V. Coordination of TP53 Abnormalities in Breast Cancer: Data from Analysis of TP53 Polymorphisms, Loss of Heterozygosity, Methylation, and Mutations // Genet Test Mol Biomarkers. 2011 Aug 2. – 7 c. – http://elibrary.ru/item.asp?id=18031116


33. Ponomaryova A. A., Rykova Elena Yu, Cherdyntseva N. V., Skvortsova T. E., Alexey Yu Dobrodeev, Zav’yalov A. A., Tuzikov S. A., Vlassov V. V., Laktionov P. P. RARb2 gene methylation level in the circulating DNA from blood of patients with lung cancer // European Journal of Cancer Prevention. – 2011. – Vol. 20, № 6. – P. 453-455. – http://elibrary.ru/item.asp?id=18008647


34. Babyshkina N., Malinovskaya E., Stakheyeva M., Volkomorov V.,Slonimskaya E., Maximov V., Cherdyntseva N. Association of functional -509C>T polymorphism in the TGF-β1 gene with infiltrating ductal breast carcinoma risk in a Russian Western Siberian population. // Cancer Epidemiology. – 2011. – Vol.35, № 6. – P. 560-3. – http://elibrary.ru/item.asp?id=23957917


35. Zavyalova M.V., Perelmuter V.M., Vtorushin S.V., Denisov E.V., Litviakov N.V., Slonimskaya E.M., Cherdyntseva N. V. The presence of alveolar structures in invasive ductal NOS Breast Carcinoma is associated with lymph node metastasis // Diagnostic Cytopathology. – 2011. Nov 18. doi: 10.1002/dc.21852.


36. Cherdyntseva N. V., Gervas P. A., Litvyakov N. V., Stakcheeva M. N., Ponomaryeva A.A., Dobrodeev A. Yu., Denisov E. V., Belyavskaya V. A., Choinzonov E. L. Age-related function of tumor suppressor gene TP53: contribution to cancer risk and progression // Experimental oncology. - 2010. – № 3. – C. 205-208. – http://elibrary.ru/item.asp?id=16575811