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Marina R. Patysheva

Marina R. Patysheva

Junior Researcher at the Laboratory of Cancer Progression Biology, Cancer Research Institute, TNRMC; Junior Researcher at the Laboratory for Translational Cell and Molecular Biomedicine, National Tomsk State University



Brief biography


Siberian State Medical University (2001-2007)

Course: clinical biochemistry

Specialty: clinical biochemistry

Novokuznetsk State Institute for Advanced Medical Studies (2007-2008)                            

Internship: clinical laboratory diagnostic, MD degree

Siberian State Medical University

Internship: clinical laboratory genetic, MD degree

Work Experience:

2007-2008: junior researcher, Laboratory of immunology of Cancer Research Institute, Tomsk

2008-2019: clinical laboratory scientist, Laboratory of Immunology, Cancer Research  Institute, Tomsk

2019- present :   junior researcher, Laboratory for Translational Cell and Molecular Biomedicine, National Tomsk State University
2019- present:    junior researcher, Laboratory of Cancer Progression Biology. Cancer Research Institute, Tomsk National Research Medical Centre   

Languages: Russian, English
Skills and expertise: cell culture, flow cytometry, qPCR

Research Interests 

Сancer, oncoimmunology, monocytes, macrophages, inflammation, exosome, chemotherapy and target therapy of cancer.

Area of scientific: cancer, oncoimmunology, monocytes, macrophages, inflammation, exosome, chemotherapy and target therapy of cancer.

Achievements, awards, and grants

1.      RNF № 19-15-00151. The role of monocyte programming in the development of pro- and anti-tumor phenotypes of tumor-associated macrophages and efficiency of chemotherapy in colorectal cancer. (2019-2021)
2.      RFBR №17-29-06037. Genomic regulation of the breast cancer progression during chemotherapy. (2018-2020)
3.      RFBR № 18-415-703006. Tetraspanins and proteases of exosomes as prognostic factors and predictors of hematogenous metastasis in colorectal cancer. (2018-2019)


European Macrophage and Dendritic cell Society (EMDS)
Russian Society of Clinical Oncology (RUSSCO)


1.      Larionova, N. Cherdyntseva, T. Liu, M. Patysheva, M. Rakina, J. Kzhyshkowska. Interaction of tumor-associated macrophages and cancer chemotherapy. Oncoimmunology. – 2019. – V.8, № 7. DOI: 10.1080/2162402X.2019.1596004

2.       Patysheva M, Stakheyeva M, Larionova I, Fedorov A, Kzhyshkowska J, Cherdyntseva N. Cytostatic cancer therapy modulates monocyte-macrophage cell functions: how it impacts on treatment outcomes. Exp Oncol. 2019 Sep;41(3):248-253. DOI: 10.32471/exp-oncology.2312-8852.vol-41-no-3.13597.

3.      Patysheva M.R., Stakheeva M.N., Larionova I.V., Tarabanovskaya N.A., Grigorieva E.S., Slonimskaya E.M., Kzhyshkowska J.G., Cherdyntseva N.V. Monocytes and cancer: promising role as a diagnostic marker and application in therapy. Bulletin of Siberian Medicine. 2019;18(1):60-75. (In Russ.)

4.      Yunusova NVPatysheva MRMolchanov SVZambalova EAGrigor'eva AEKolomiets LAOchirov MOTamkovich SNKondakova IV// Metalloproteinases at the surface of small extrcellular vesicles in advanced ovarian cancer: Relationships with ascites volume and peritoneal canceromatosis index. Clin Chim Acta. 2019 Jul;494:116-122. DOI: 10.1016/j.cca.2019.03.162

5.        M. Stakheyeva , D. Eidenzon, E. Slonimskaya, M. Patysheva, I.Bogdashin, E. Kolegova , N. Cherdyntseva. Integral characteristic of the immune system state predicts breast cancer outcome// Experimental Oncology Exp Oncol. 2019 Mar;41(1):32-38.DOI 10.32471/exp-oncology.2312-8852.vol-41-no-1.12593

6.        Tugutova EATamkovich SNPatysheva MRAfanas’ev SGTsydenova AAGrigor’eva AEKolegova ESKondakova IVYunusova NV. Relation of tetraspanin- associated and tetraspanin-non-associated proteases in exosomes with stage and metabolic syndrome in colorectal cancer patients// Asian Pac J Cancer Prev. 2019 Mar 26;20(3):809-815.DOI:10.31557/APJCP.2019.20.3.809

7.      Cherdyntseva N.V., Mitrofanova I.V., Buldakov M.A., Stakheeva M.N., Patysheva M.R., Zavjalova M.V., Kzhyshkowska J.G. Macrophages and tumor progression: on the way to macrophage-specific therapy. Bulletin of Siberian Medicine. 2017;16(4):61-74. (In russ.)