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Personalities

Sergey V. Vtorushin

Sergey V. Vtorushin

Sergey V. Vtorushin, MD, PhD, DSc, Head of the Department of the General and Molecular Pathology, Cancer Research Institute, Tomsk NRMC; Professor of the Department of Pathology, Siberian State Medical University, Tomsk

Contacts

e-mail: wtorushin@rambler.ru , wtorushin@gmail.com
tel.: +7 (3822) 28-26-86

Fax: +7 (3822) 28-26-76 

Brief Biography

Work experience

2020 – Present: Head of the Department the General and Molecular Pathology, Cancer Research Institute, Tomsk NRMC 

2013 – Present: Professor, Department of Pathology, Siberian State Medical University, Tomsk

2019-2020: Leading Researcher, Department of the General and Molecular Pathology, Cancer Research Institute, Tomsk NRMC

2010 – 2018: Senior Researcher, Department of the General and Molecular Pathology, Cancer Research Institute, Tomsk NRMC

2009-2013: Associate professor of the Pathology Department, pathologist, Siberian State Medical University, Tomsk

2004-2009: Assistant professor of the Department of Pathological Anatomy, pathologist, Siberian State Medical University, Tomsk

Education

2013-2015: MSc, «Management in the scientific and educational field», Tomsk Polytechnic University, Tomsk

2004-2006: PhD in Pathology, Siberian State Medical University, Tomsk

2002-2004: Residency in Pathology, Siberian State Medical University, Tomsk

1996-2002: MD, Pediatry, Siberian State Medical University, Tomsk

Research Interests

·         molecular mechanisms of tumor progression of malignant neoplasms

·         morphological and biological heterogeneity of malignant tumors

·         mechanisms of resistance to various types of treatment as the basis for predicting and personalized treatment of cancer

Projects

S.V. Vtorushin is the manager and executor of projects supported by federal grants:

·         «Development of new approaches to determining the drug sensitivity of breast cancer considering the morphological heterogeneity of the tumor», Grants Council under the President of the Russian Federation (Agreement No. 14.122.13.491-MD of 04/04/2013);

·         «Identification of protein markers for the diagnosis and prognosis of gastric cancer»(GK No. 02.740.11.0769 dated 04/12/2010)

·         «Optimization of the chemotherapy strategy for breast cancer based on chemoresistance and chemosensitivity factors» (Agreement No. 8291 of 08/27/2012 ) in the framework of the Federal target program "Scientific and scientific-pedagogical personnel of innovative Russia" for 2009-2013;

·         «A study of the relationship of the molecular biological and morphological parameters of triple-negative breast cancer associated with chemotherapy resistance», grant of Russian Foundation for Basic Research (RFBR), (2014);

·         «Development of new approaches to predicting the course and effectiveness of cancer therapy (breast cancer, squamous cell carcinoma of the larynx, laryngopharynx) based on the use of chaperones as molecular markers», grant of the President of the Russian Federation for state support of young Russian scientists (contract No. 14.120.14.168 -MD from 02/03/2014);

·         «Development of new approaches to predicting the resistance of hormone therapy in patients with luminal breast cancer based on the assessment of clinical, morphological and molecular genetic parameters of the tumor», grant of the President of the Russian Federation for state support of young Russian scientists (MD-9084.2016.7, 2016-2017).

Awards

·         2012 - Honorary diploma of the Tomsk city Administration;

·         2014 - Laureate of the prize of the Legislative Duma of the Tomsk Region in the nomination «Natural Sciences»;

·         2014 – «Laureate of the Tomsk Region Prize in the field of education, science, healthcare and culture»;

·         2015 - Certificate of Honor from the Governor of Tomsk Region for his great contribution to the development of scientific research;

·         2017 - Certificate of Honor of the Ministry of Health of the Russian Federation;

·         2017 – 2nd degree diploma in the All-Russian competition of doctors of the Ministry of Health of the Russian Federation, nomination «Best Expert»;

·         2019 - The Medal «Excellence in Health Care» of the Ministry of Health of the Russian Federation;

·         2019 – «Laureate of the Tomsk Region Prize in the field of education, science, healthcare and culture». Award to scientific and scientific-pedagogical workers who have made a significant personal contribution to the development of science and education.

Memberships

• Chairman of the regional branch of the Russian Society of Oncopathologists

• Member of the European Society of Pathology

Publications

S.V. Vtorushin is the author of more than 170 publications, of which 136 scientific papers, including 57 articles in leading peer-reviewed journals and publications from the list of the Higher Attestation Commission of the Russian Federation, 15 teaching and practical manuals, 14 patents of the Russian Federation, 1 permission to use new medical technology, 1 know-how, 10 databases.

Selected publications

1.    Babyshkina, N., Vtorushin, S., Dronova, T., Cherdyntseva, N., Choynzonov, E. / Impact of estrogen receptor α on the tamoxifen response and prognosis in luminal-A-like and luminal-B-like breast cancer // Clinical and Experimental Medicine. – 2019. – V.19 (4), P. 547-55.

2.    Vtorushin S.V., Rachkovsky K.V., Krakhmal N.V., Stepanov I.V., Zavyalova M.V./A link between autophagy regulatory proteins m-tor and beclin-1 and parameters of lymphogenic metastasis in colorectal cancer // Siberian Journal of Oncology. – 2018. – V. 17. – № 4 – P. 41-47.

3.    Babyshkina N., Dronova T., Litviakov N., Cherdyntseva N., Patalyak S., Slonimskaya E., Vtorushin S., Zavyalova M., Kzhyshkowska J., Choynzonov E. / The distribution pattern of ERα expression, esr1 genetic variation and expression of growth factor receptors: association with breast cancer prognosis in russian patients treated with adjuvant tamoxifen // Clinical and Experimental Medicine. – 2017. – Т. 17. – № 3. – P. 383-393.

4.    Vtorushin S.V., Malykh R.D. / Modern background for the molecular genetic classification of endometrial cancer // Archive of Pathology. - 2017. - V. 79. No. 3. - P. 57-62.

5.    Vtorushin S.V., Bezgodova N.V., Pleshkunov A.A. / Molecular biological prediction factors for prostate cancer // Siberian Journal of Oncology. - 2017. V. - 16. No. 1. - P. 82-90.

6.    Babyshkina N.N., Vtorushin S.V., Dronova T.A., Krakhmal N.V., Zavyalova M.V., Tsyganov M.M., Patalyak S.V., Slonimskaya E.M., Cherdyntseva N.V. / The role of the β-type transforming growth factor receptor (TGF-b) in the progression of the luminal subtype of breast cancer // Siberian Oncology Journal. - 2017. - V. 16. - No. 2. - P. 27-35.

7.    Rachkovsky K.V., Vtorushin S.V., Stepanov I.V., Naumov S.S., Zavyalova M.V., Afanasyev S.G. / The role of autophagy and angiogenesis in colorectal cancer // Siberian Oncology Journal. 2017. V. 16. - No. 6. - P. 86-92.

8.    Gerashchenko T.S., Zavyalova M.V., Denisov E.V., Krakhmal N.V., Pautova D.N., Litviakov N.V., Vtorushin S.V., Cherdyntseva N.V., Perelmuter V.M. / Intratumoral morphological heterogeneity of breast cancer as an indicator of the metastatic potential and tumor chemosensitivity // Acta Naturae. – 2017. – V. 9. – № 1 (32). P. 56-67.

9.    Buldakov M., Zavyalova M., Krakhmal N., Vtorushin S., Mitrofanova I., Riabov V., Cherdyntseva N., Kzhyshkowska J., Telegina N., Yin S., Song B. / CD68+, but not stabilin-1+ tumor associated macrophages in gaps of ductal tumor structures negatively correlate with the lymphatic metastasis in human breast cancer // Immunobiology. – 2017. V. – 222. – № 1. – P. 31-38.         

10. Denisov E.V., Gerashchenko T.S., Buldakov M.A., Cherdyntseva N.V., Zavyalova M.V., Skryabin N.A., Lebedev I.N., Tashireva L.A., Vtorushin S.V., Perelmuter V.M., Wilhelm J., Sleptcov A.A. / Clinically relevant morphological structures in breast cancer represent transcriptionally distinct tumor cell populations with varied degrees of epithelial-mesenchymal transition and CD44+CD24- stemness // Oncotarget. – 2017. – V. 8. – № 37. – P. 61163-61180.

11. Krakhmal N.V., Zavyalova M.V., Denisov E.V., Vtorushin S.V., Perelmuter V.M. Invasion of tumor epithelial cells: mechanisms and manifestations // Acta Naturae. - 2015. - T. 7, No. 2 (25). - S. 18-31.

12. Zavyalova M., Vtorushin S., Krakhmal N., Savelieva O., Tashireva L., Kaigorodova E., Perelmuter V., Telegina N., Denisov E., Bragina O., Slonimskaya E., Choynzonov E. / Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes // Experimental Oncology. – 2016. – V. 38. – № 2. – P.122-127.  

13. Vtorushin S.V., Khristenko K.Y., Zavyalova M.V., Perelmuter V.M., Dulesova A.Y., Cherdyntseva N.V., Litviakov N.V., Denisov E.V. / The phenomenon of multi-drug resistance in the treatment of malignant tumors // Experimental Oncology. – 2014. – V. 36. – № 3. – P.144-156.

14. Litviakov N.V., Cherdyntseva N.V., Tsyganov M.M., Denisov E.V., Merzliakova M.K., Volkomorov V.V., Slonimskaya E.M., Garbukov E.Y., Vtorushin S.V., Zavyalova M.V., Perelmuter V.M. / Changing the expression vector of multidrug resistance genes is related to neoadjuvant chemotherapy response // Cancer Chemotherapy and Pharmacology. - 2013. - V. 71. - № 1. - P. 153-163.

15. Gerashchenko T.S., Denisov E.V., Litviakov N.V., Zavyalova M.V., Vtorushin S.V., Tsyganov M.M., Perelmuter V.M., Cherdyntseva N.V. / Intratumor heterogeneity: nature and biological significance // Biochemistry (Moscow). - 2013. - V. 78. - № 11. - P. 1201-1215.

16. 16. Litvyakov N.V., Garbukov E.Yu., Slonimskaya E.M., Tsyganov M.M., Denisov E.V., Vtorushin S.V., Khristenko K.Yu., Zavyalova M.V., Cherdyntseva N.V. / Relationship between metastatic survival of breast cancer patients and the vector of changes in gene expression of multidrug resistance in a tumor during neoadjuvant chemotherapy // Oncology Issues. - 2013. - V. 59. - No. 3. - P. 334-340.

17. Zavyalova M.V., Perelmuter V.M., Vtorushin S.V., Denisov E.V., Litvyakov N.V., Cherdyntseva N.V., Slonimskaya E.M. / The presence of alveolar structures in invasive ductal nos breast carcinoma associated with lymph node metastasis // Diagnostic Cytopathology. - 2013. - V. 41. - № 3. - P. 279-282.

18. Zavyalova M.V., Denisov E.V., Tashireva L.A., Gerashchenko T.S., Litviakov N.V., Skryabin N.A., Vtorushin S.V., Telegina N.S., Slonimskaya E.M., Cherdyntseva N.V., Perelmuter V.M. / Phenotypic drift as a cause for intratumoral morphological heterogeneity of invasive ductal breast carcinoma not otherwise specified // BioResearch Open Access. - 2013. - V. 2. - № 2. - P. 148-154.

19. Perelmuter V.M., Zavyalova M.V., Vtorushin S.V., Slonimskaya E.M., Kritskaya N.G., Garbukov E.Yu., Litvyakov N.V., Stakheeva M.N., Babyshkina N.N., Malinovskaya E.A., Denisov E.V., Grigoryeva E.S., Nazarenko M.S., Sennikov S.V., Goreva E.P., Kozlov V.A., Voevoda M .I., Maksimov V.N., Belyavskaya V.A., Cherdyntseva N.V. et al. / Genetic and clinical and pathological features of breast cancer in patients with preserved menstrual function in menopause // Successes in Gerontology. - 2008. - V. 21. - No. 4. - P. 643-653.