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Personalities

Tatiana S. Gerashchenko

Tatiana S. Gerashchenko

PhD, Senior Researcher, Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk NRMC

Contact details

email: t_gerashenko@list.ru 

phone: +7(3822) 282676, add 3345; 

Brief CV

Work experience:

2013-2016: PhD student, Laboratory of Molecular Oncology and Immunology, Tomsk Cancer Research Institute

2014-2019: Junior Researcher, Laboratory for Translational Cellular and Molecular Biomedicine, Tomsk State University

2016-2019: Junior Researcher, Laboratory of Molecular Oncology and Immunology, Cancer Research Institute, Tomsk National Research Medical Center

2019-2023: Researcher, Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk National Research Medical Center

November 2022 – Senior Researcher, Laboratory of Single Cell Biology, Research Institute of Molecular and Cellular Medicine, Peoples’ Friendship University of Russia (RUDN University; part-time)

November 2022 – present, Senior Researcher, Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk National Research Medical Center

International experience:

05.05.2014 – 02.06.2014: Traineeship in Institute for Transfusion Medicine and Immunology, University of Heidelberg, Heidelberg, Germany

18.10.2014 – 29.10.2014 - Traineeship in ECCPS Microarray Unit, University of Giessen, Giessen, Germany 

Education:

2012-2013: Internship, Siberian State Medical University.

2006-2012: MD student, Department of Biochemistry and Molecular Biology, Siberian State Medical University. Training and MD research work at Tomsk Cancer Research Institute

Research Interests 

Functional changes of immune cells in blood and tumor microenvironment of breast cancer patients under chemotherapy

Premalignant process in bronchial epithelium: genotypic factors, involved in metastasis and recurrence of patients with NSCLC.

Intratumoral morphological heterogeneity of breast cancer: nature and clinical significance. Molecular mechanisms of breast cancer invasion and metastasis.

Projects:

Gerashchenko T.S. was involved in more than ten projects, supported by Russian Science Foundation (RSF), Russian Foundation for Basic Research (RFBR), Russian President Grants and others.

Current major projects:

Functional makeup of immune cells as a factor of breast cancer chemotherapy efficacy (RSF, 2022-2025)

Genetic determinants of distant metastasis in non-small cell lung carcinoma (RSF, 2020-2023)

- «Genetic alterations involved in tumor cell invasion and their role in breast cancer development» (RFBR, 2018-2021)

- «New strategy for the prediction and prevention of distant metastasis based on the detection of circulating metastasis-initiating and niche-forming cells and their specific targets» (RSF, 2019-2022)

- «Ethno-specific mutations, predisposing to breast cancer development among the indigenous population of Siberia and the Far East» (RFBR, 2018-2021)

Awards 

Ministry of Education and Science of the Russian Federation Award "Young Scientist" (2024)

Russian President scholarship holder (2021-2023)

Tomsk region award in field of education, science and medicine holder (2018)

Russian Government scholarship holder (2011/2012; 2015/2016)

ESO (2015) Travel Grant holder

State Duma of Tomsk region award holder (2015)

Administration of Tomsk region’ scholarship holder (2014/2015)

Scholarship of «Pfizer» for overseas training (2014)

EACR Meeting Bursary Award (2013)

Fellowship of Russian Winter School «Modern Biology&Future Biotech» (2013)

Memberships

European Society for Medical Oncology (ESMO, 2017 – present)

European Association for Cancer Research (EACR, 2013 - 2022)

Federation of European Biochemical Societies (FEBS, 2013 – present)

Publications

1.         T.S. Gerashchenko, R.S. Skitchenko, A.A. Schegoleva, K.A. Kuanysheva, A.A. Khozyainova, R.S. Vorobiev, E.O. Rodionov, S.V. Miller, E.B. Topolnitsky, N.A. Shefer, M.S. Anisimenko, L.D. Zhuikova, M. Vashisth, O.V. Pankova, V.M. Perelmuter, V. Rezapova, M. Artomov, E.V. Denisov. Whole-exome sequencing reveals an association of rs112065068 in TGOLN2 gene with distant metastasis of non-small cell lung cancer //Gene. – 2024. – Т. 920. – С. 148507. https://doi.org/10.1016/j.gene.2024.148507  

2.         T. Gerashchenko, A. Frolova, M. Patysheva, A. Fedorov, M. Stakheyeva, E. Denisov. Breast Cancer Immune Landscape: Interplay Between Systemic and Local Immunity //Advanced Biology. – 2024. – С. 2400140. https://doi.org/10.1002/adbi.202400140

3.         Gerashchenko TS, Schegoleva AA, Khozyainova AA, Choinzonov EL, Denisov EV. Metastasis prevention: How to catch metastatic seeds. Biochim Biophys Acta Rev Cancer. 2023 Feb 24;1878(3):188867. https://doi.org/10.1016/j.bbcan.2023.188867  

4.         A.A. Ponomaryova, A.A. Schegoleva, P.A. Gervas, O.V. Pancova, T.S. Gerashchenko, A.A. Zarubin, V.M. Perelmuter, N.V. Cherdyntseva, E.V. Denisov. DNA methylome analysis reveals potential alterations contributing to the progression of bronchial hyperplasia. Mol Biol Rep. 2023 Jul 22. https://doi.org/10.1007/s11033-023-08571-6

5.         Iamshchikov P., Larionova I., Gerashchenko T., Piankov D., Koshkin P., Korostelev S., Denisov E. Comparison of the Illumina NextSeq 2000 and GeneMind Genolab M sequencing platforms for spatial transcriptomics. BMC Genomics. 2023 Mar 7;24(1):102. https://doi.org/10.1186/s12864-023-09192-w

6.         L.A. Tashireva, A.Y. Kalinchuk, T.S. Gerashchenko, M. Menyailo, A. Khozyainova, E.V. Denisov, V.M. Perelmuter. Spatial profile of tumor microenvironment in PD-L1-negative and PD-L1-positive triple-negative breast cancer. Int. J. Mol. Sci. 2023 11;24(2):1433. https://doi.org/10.3390/ijms24021433

7.         Menyailo ME, Zainullina VR, Khozyainova AA, Tashireva LA, Zolotareva SY, Gerashchenko TS, Alifanov VV, Savelieva OE, Grigoryeva ES, Tarabanovskaya NA, Popova NO, Choinzonov EL, Cherdyntseva NV, Perelmuter VM, Denisov EV. Heterogeneity of Circulating Epithelial Cells in Breast Cancer at Single-Cell Resolution: Identifying Tumor and Hybrid Cells. Adv Biol (Weinh). 2023 Feb;7(2):e2200206. https://doi.org/10.1002/adbi.202200206  

8.         A.A. Schegoleva, A.A. Khozyainova, T.S. Gerashchenko, L.D. Zhuikova, E.V. Denisov. Metastasis prevention: targeting causes and roots. Clinical & Experimental Metastasis 2022; 39 – 505-519. https://doi.org/10.1007/s10585-022-10162-x

9.         Schegoleva     A.A., Khozyainova A.A., Fedorov A.A. Gerashchenko T.S., Rodionov E.O., Topolnitsky E.B. Shefer N.A., Pankova O.V. Durova A.A., M.V. Zavyalova, Perelmuter V.M., E.V. Denisov. Prognosis of Different Types of Non-Small Cell Lung Cancer Progression: Current State and Perspectives. Cell Physiol Biochem 2021;55(S2):29-48/ DOI: https://www.cellphysiolbiochem.com/Articles/000340/PDF/000340.pdf

10.      O.V. Pankova, L.A. Tashireva, E.O. Rodionov, S.V. Miller, S.A. Tuzikov, D.S. Pismenny, T.S. Gerashchenko, M.V. Zavyalova, S.V. Vtorushin, E.V. Denisov, V.M. Perelmuter. Premalignant changes in the bronchial epithelium are prognostic factors of distant metastasis in NSCLC patients. Front. Oncol. 2021; 11 –771802. https://www.frontiersin.org/articles/10.3389/fonc.2021.771802/full

11.      Larionova I., Kazakova E., Gerashchenko T., Kzhyshkowska J. New angiogenic regulators produced by tams: Perspective for targeting tumor angiogenesis. Cancers. 2021;13. – 3253. - doi: 10.3390/cancers13133253

12.      L.A. Tashireva, M.V. Zavyalova, O.E. Savelieva, T.S. Gerashchenko, E.V. Kaigorodova, E.V. Denisov, V.M. Perelmuter. Single Tumor Cells With Epithelial-Like Morphology Are Associated With Breast Cancer Metastasis // Front. Oncol. – 2020. – Vol. 10, P. 1-12 https://www.frontiersin.org/articles/10.3389/fonc.2020.00050/full

13.      T.S. Gerashchenko, N. M. Novikov, N. V. Krakhmal, S.Y. Zolotaryova, M.V. Zavyalova, N.V. Cherdyntseva, E. V. Denisov and V. M. Perelmuter. Markers of Cancer Cell Invasion: Are They Good Enough? // Journal of Clinical Medicine. – 2019. – Vol. 8. – P. 2-18 https://www.ncbi.nlm.nih.gov/pubmed/31344926

14.      Denisov, E.V., Schegoleva, A.A., Gerashchenko, T.S., Skryabin, N.A., Sleptcov, A.A., Yakushina, V.D., Lyapunova, L.S., Tuzikov, S.A., Pankova, O.V., Perelmuter, V.M. Gene expression profiling revealed two types of bronchial basal cell hyperplasia and squamous metaplasia with different progression potentials. - Applied Immunohistochemistry & Molecular Morphology. – 2019. https://www.ncbi.nlm.nih.gov/pubmed/30896548

15.      Gerashchenko TS, Denisov EV, Novikov NM, Tashireva LA, Kaigorodova EV, Savelieva OE, Zavyalova MV, Cherdyntseva NV, Perelmuter VM. Different morphological structures of breast tumors demonstrate individual drug resistance gene expression profiles.// Exp Oncol. – 2018. - Vol.40, № 3. – P. 228-234. http://exp-oncology.com.ua/article/11551

16.      L.A. Tashireva, E.V. Denisov, T.S. Gerashchenko, D.N. Pautova, M.A. Buldakov, M.V. Zavyalova, J. Kzhyshkowska, N.V. Cherdyntseva, V.M. Perelmuter. Intratumoral heterogeneity of macrophages and fibroblasts in breast cancer is associated with the morphological diversity of tumor cells and contributes to lymph node metastasis // Immunobiology. 2017 Apr;222(4):631-640. https://www.sciencedirect.com/science/article/pii/S0171298516304478?via%3Dihub

17.      E.V. Denisov, N. A. Skryabin, T. S. Gerashchenko, L. A. Tashireva, J. Wilhelm, M.A. Buldakov, A.A. Sleptcov, I.N. Lebedev, S.V. Vtorushin, M.V. Zavyalova, N.V. Cherdyntseva, V.M Perelmuter. Clinically relevant morphological structures in breast cancer represent transcriptionally distinct tumor cell populations with varied degrees of epithelial-mesenchymal transition and CD44+ CD24-stemness. – Oncotarget, 2017. – P. 1-17. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=18022&path[]=59000

18.      TS Gerashchenko, MV Zavyalova, EV Denisov, NV Krakhmal, DN Pautova, NV Litviakov, SV Vtorushin, NV Cherdyntseva, VM Perelmuter. Intratumoral Morphological Heterogeneity of Breast Cancer As an Indicator of the Metastatic Potential and Tumor Chemosensitivity // Acta Naturae. – 2017. – Vol.9 (1). – P. 56-67 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406661/

19.      Denisov E. V., Gerashchenko T. S., Zavyalova M. V., Manskikh V. N., Choinzonov E. L., Cherdyntseva N. V., and V. M. Perelmuter. Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma. - Springer International Publishing Switzerland, 2016 B.I. Carr (ed.), Hepatocellular Carcinoma, Current Clinical Oncology. – P.211 – 228. https://link.springer.com/chapter/10.1007%2F978-3-319-34214-6_14

20.      L. A. Tashireva, E. V. Denisov, O. E. Savelieva, T. S. Gerashchenko, M. V. Zavyalova, V. M. Perelmuter. Heterogeneity of premetastatic niche gene expression in breast cancer cells // Biopolymers and Cell. 2015. Vol. 31. N 6. – P. 429–435 doi: http://dx.doi.org/10.7124/bc.000900

21.      Olga V. Pankova, Evgeny V. Denisov, Anastasia A. Ponomaryova, Tatiana S. Gerashchenko, Sergey A. Tuzikov, Vladimir M. Perelmuter. Recurrence of squamous cell lung carcinoma is associated with the co-presence of reactive lesions in tumor-adjacent bronchial epithelium // Tumor Biology, 2016. –Vol. 37(3). - P.3599-3607. https://link.springer.com/article/10.1007/s13277-015-4196-2

22.      Denisov E.V., Skryabin N.A., Vasilyev S.A., Gerashchenko T.S., Lebedev I.N., Zavyalova M.V., Cherdyntseva N.V., Perelmuter V.M. Relationship between morphological and cytogenetic heterogeneity in invasive micropapillary carcinoma of the breast: a report of one case // J Clin. Pathol., 2015. - Vol. 68(9). – P.758-762. http://jcp.bmj.com/content/68/9/758.long

23.      E. V. Denisov, T. S. Gerashchenko, M. V. Zavyalova, N. V. Litviakov, M. M. Tsyganov, E. V. Kaigorodova, E. M. Slonimskaya, J. Kzhyshkowska, N. V. Cherdyntseva, V. M. Perelmuter. Invasive and drug resistant expression profile of different morphological structures of breast tumors // Neoplasma. – 2015 62(3), P.405-411. https://www.ncbi.nlm.nih.gov/pubmed/25672673

24.      E.V. Denisov, N.V. Litviakov, M.V. Zavyalova, V.M. Perelmuter, S.V. Vtorushin, M.M. Tsyganov, T.S. Gerashchenko, E. Yu. Garbukov, E.M. Slonimskaya, N.V. Chedryntseva. Intratumoral morphological heterogeneity of breast cancer: neoadjuvant chemotherapy efficiency and multidrug resistant gene expression // Scientific reports. – 2014. - N 4, 4709, P. 1-7. https://www.nature.com/articles/srep04709

25.      Gerashchenko T.S., Denisov E.V., Litviakov N.V., Zavyalova M.V., Vtorushin S.V., Tsyganov M.M., Perelmuter V.M., Chedryntseva N.V. Intratumoral heterogeneity:nature and biological significant // Biochemistry (Moscow) / - 2013. – Vol. 78, P. 1201-1215. https://link.springer.com/article/10.1134%2FS0006297913110011

26.      M.V. Zavyalova, E.V. Denisov, L.A. Tashireva, T.S. Gerashchenko, N.V. Litviakov, N.A. Skryabin, S.V. Vtoryshin, N.S. Telegina, E.M. Slonimskaya, N.V. Cherdyntseva, V.M. Perelmuter. Phenotypic Drift as a Cause for Intratumoral Morphological Heterogeneity of Invasive Ductal Breast Carcinoma Not Otherwise Specified // Bioresearch Open Access. - 2013. - Vol. 2, N. 2. – P. 148-154 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620470/