Version for the visually impaired:
Font size:
a
a
a

Personalities

Svetlana A. Ivanova

Svetlana A. Ivanova

Svetlana A. Ivanova, Ph.D., D.Sc., Professor, Deputy Director for Science of Mental Health Research Institute Tomsk NRMC, Head of Molecular Genetics and Biochemistry Laboratory of Mental Health Research Institute, Professor of National Research Tomsk Polytechnic University.

Contact information

e-mail: ivanovaniipz@gmail.com
tel.: 8 (3822) 72-31-77; 72-43-79
fax: 8 (3822) 72-44-25

Brief Biography

Svetlana A. Ivanova graduated from Siberian State Medical University in 1987. In 1987 she was employed at the Mental Health Research Institute, Russian Academy of Medical Sciences.

In 1990, she obtained her PhD degree (specialty:  psychiatry and pathological physiology) and in 2001 she defended doctoral thesis for an academic degree of Doctor of Sciences.

In 2003, she was appointed as a Head of Cellular and Molecular-Biological Laboratory.

In 2008, Svetlana A. Ivanova was awarded the rank of Professor in discipline of Psychiatry. 

Since 2013, Prof. Ivanova has been a Deputy Director for Science of the Mental Health Research Institute and the Head of Molecular Genetics and Biochemistry Laboratory

Research Interests

Biological psychiatry, molecular genetics, pharmacogenetics, biochemistry, biomarkers of mental disorders, translational psychiatry.

Achievements, awards, and grants

Svetlana A. Ivanova is an author of more than 450 scientific publications, including 15 books, 19 patients, 175 articles and more than 100 abstracts of conferences. 

Under supervision of Svetlana A. Ivanova, 2 dissertations for a degree of Doctor of Sciences and 13 dissertations for a degree of Candidate of Sciences (equivalent of Ph.D.) have been defended.

Diplomas and prizes:

Honorary Diploma of the Presidium of the Russian Academy of Sciences (2017),

Honorary Diploma of Presidium of Siberian Branch of Russian Academy of Medical Sciences (2001),

Honorary Diploma of Russian Academy of Medical Sciences (2007),

Honorary Diploma of Administration of Tomsk Region (2009),

Honorary Diploma of Council of Rectors of high schools of Tomsk (2014).

Anniversary medal "70 years of the Tomsk Region" (2014),

Medal "For Achievements" (2016),

Prize of the winner of competition of Administration of the Tomsk Region in the field of education and science, health and culture (2016).

Prize of the winner of competition of Administration of the Tomsk Region in education and science, health care and culture as a Head of group of authors (for investigation “Mechanisms of apoptosis under conditions of oxidative stress in mental and substance use disorders”) (2009).

Prize of the winner of competition of Administration of the Tomsk Region in education and science, health care and culture as a part of group of authors (2007).

Prize of the winner of Regional Public Fund of promotion of domestic medicine and Presidium of Russian Academy of Medical Sciences in the field of medicine, nomination “Clinical medicine” (2001-2002).

Prize of the winner of competition of Administration of the Tomsk Region among young scientists in the field of science and education (1999).

Memberships in scientific societies:

European College of Neuropsychopharmacology (ECNP),

International College of Neuropsychopharmacology (CINP),

World Society of Biological Psychiatry,

Russian Society of Psychiatry,

International Association of Ethnopsychologists and     

Ethnopsychotherapists,

World Association of Cultural Psychiatry.

Memberships:

member of the educational committee of the International College of Neuropsychopharmacology (2016-2018);

member of Public Organization “Tomsk Professors’ Assembly”.

Member of Academic Council of  “Mental Health Research Institute”, member of Dissertation Council D 002.279.05 in specialties "Psychiatry" (14.01.06)  at  “Mental Health Research Institute”; member of Dissertation Council D 208.096.01 in “Pathological physiology” (14.03.03) at ” Siberian State Medical University” of Ministry of Healthcare of Russian Federation.

Participation in Editorial Boards:            

Deputy Editor-in-Chief of the journal “Siberian Herald of Psychiatry and Addiction Psychiatry” (Tomsk);

member of Editorial Board of peer-reviewed journal “Ural Herald of Psychiatry and Addiction Psychiatry” (Yekaterinburg);

member of the editorial board of "Mental Health" (Moscow)

Grants and projects:

  1. Contract Federal target program № 14.601.21.0015 on the theme "Development of a forecast for the implementation of the priority of scientific and technological development defined in paragraph 20c". Transition to personalized medicine, high-tech health care and health saving technologies, including rational use of medicines (primarily antibacterial drugs). " - technological development of the Russian Federation ", 2017 (responsible executive);

  2. RFBR 17-29-06035 "New approaches to the pharmacogenetics of antipsychotic-induced hyperprolactinaemia in patients with schizophrenia" 2017-2020 (head);

  3. Contract No. 5007 of June 22, 2017 for the implementation of the research "Role of polymorphisms of neurotransmitter transporter genes in the development of drug-induced motor disorders in schizophrenia and Parkinson's disease", 2017, (head);

  4. RSF 14-15-00480 "The search for biomarkers of socially significant endogenous mental disorders", 2014-2016 (head);

  5. RSF 14-35-00023 "Laboratory of pharmacogenetic research on personalized therapy of mental and neurodegenerative disorders", 2014-2016 (responsible executive);

  6. RFBR (Russian Foundation for Basic Research) № 14-04-01157-a “Search for biomarkers of depressive and affective disorders”, 2014-2016, (head);

  7. RFBR 17-29-02205 (Russian Foundation for Basic Research) "Development of the molecular genetic panel of depressive disorders based on polymorphisms of the genes of neuronal kinases, neurotrophic proteins and genes of the serotonergic system", 2017-2019 (responsible executive);

  8. Contract No. 4110 of August 25, 2016 for the implementation of the research "Study of the association of polymorphism of the genes of neurotransmitter transporters in patients with depressive disorders with response to antidepressant therapy", 2016, (head);

  9. RHF (Russian Foundation for Humanities)  № 14-04-00531 а "Psychosocial, ethno-cultural and genetic determinants of alcohol dependence among the indigenous population of Siberia", 2014-2016, (responsible executive).

  10. Contract No. 3855 dated July 7, 2015 for the implementation of the research "Study of associations of polymorphism of the genes of neurotransmitter system transporters in patients with schizophrenia with side effects of antipsychotic therapy (hyperprolactinemia)", 2015, (head);

  11.  Agreement about scientific collaboration between Department of Pharmacotherapy and Pharmaceutical Care of the Groningen Research Institute of Pharmacy, University of Groningen, the Netherlands   and Mental Health Research Institute of Siberian Branch of RAMSci on Project. “Dried Blood Spot  for detection of Clozapine” 2013-2015 (co-supervisor);

  12. RFBR (Russian Foundation for Basic Research) № 11-04-01102-a “Study of association of PIP5K2A gene polymorphism with socially significant mental and behavioral disorders”, 2011-2013; (head);

  13. RHF (Russian Foundation for Humanities) № 11-36-00213a1 “Serotonin system in modulation of aggressive and depressive behavior: development of new approaches to prediction, diagnosis and treatment of mental disorders”, 2011-2013; (head);

  14. Joint integration project of Siberian Branch of Russian Academy of Sciences and Siberian Branch of Russian Academy of Medical Sciences no. 5 “Medical proteomics: search for markers of mental disorders” (2012-2014);

  15. The agreement between Brianlabs BV (the Netherlands), the Department of Nuclear Medicine of the Medical Center of the University of Groningen and the Scientific Research Institute of Mental Health of the Siberian Branch of the Russian Academy of Medical Sciences on the theme "Validation of Biomarkers of Depression", 2011-2013 (co-leader);

  16. RHF (Russian Foundation for Humanities) № 11-06-00550a “Role of psychological and neuroendocrine factors in formation of aggressive pattern of behavior under conditions of penal system”, 2012-2013; (responsible executive).

  17. Federal target program "Development of a complex of markers of the main socially significant mental disorders on the basis of studying the molecular genetic mechanisms of the disruption of neuronal protein kinase signaling pathways", State contract No. 8140 (2012-2013) (responsible executor).

Books and chapters

  1. Anton J.M. Loonen, Arnt F.A. Schellekens and Svetlana A. Ivanova Circuits regulating pleasure and happiness: a focus on addiction, beyond the ventral striatum. Chapter in the book Recent Advances in Drug Addiction Research and Clinical Applications" (edited by William M. Meil and Christina L. Ruby), InTech – 2016 – p. 1-20.  ISBN 978-953-51-2492-4, DOI: 10.5772/62707  URL: http://www.intechopen.com/books/recent-advances-in-drug-addiction-research-and-clinical-applications/circuits-regulating-pleasure-and-happiness-a-focus-on-addiction-beyond-the-ventral-striatum

  2. Anton J.M. Loonen and Svetlana A. Ivanova Circuits Regulating Pleasure and Happiness in Schizophrenia: The Neurobiological Mechanism of Delusions// chapter 6 in book Schizophrenia Treatment - The New Facets Edited by Yu-Chih Shen, ISBN 978-953-51-2826-7, Print ISBN 978-953-51-2825-0, 178 pages, Publisher: InTech, Chapters published December 14, 2016 under CC BY 3.0 license DOI: 10.5772/62958. – p.109-134 URL: https://www.intechopen.com/books/schizophrenia-treatment-the-new-facets/circuits-regulating-pleasure-and-happiness-in-schizophrenia-the-neurobiological-mechanism-of-delusio


Main Publications

  1. Loonen AJM, Ivanova SA. . Circuits regulating pleasure and happiness: evolution and role in mental disorders. Acta Neuropsychiatr. 2018 Feb;30(1):29-42. doi: 10.1017/neu.2017.8. (IF 1.938) https://www.ncbi.nlm.nih.gov/pubmed/28473012

  2. Ermakov EA, Ivanova SA, Buneva VN, Nevinsky GA. Hydrolysis by catalytic IgGs of microRNA specific for patients with schizophrenia. IUBMB Life. 2018 Feb;70(2):153-164. doi: 10.1002/iub.1712 (Impact Factor: 3.141)   https://www.ncbi.nlm.nih.gov/pubmed/29341394

  3. Loonen A.J., Ivanova S.A. Commentary on "A non-reward attractor theory of depression": A proposal to include the habenula connection. Neurosci Biobehav Rev. 2017 Feb 21. pii: S0149-7634(16)30557-7. doi: 10.1016/j.neubiorev.2017.02.007 (IF 8,55).         https://www.ncbi.nlm.nih.gov/pubmed/28232092

  4. Ivanova, S. A., Osmanova, D. Z., Freidin, M. B., Fedorenko, O. Y., Boiko, A. S., Pozhidaev, I. V., Semke, A. V., Bokhan, N. A., Agarkov, A. A., Wilffert, B., Loonen A. J. Identification of 5-hydroxytryptamine receptor gene polymorphisms modulating hyperprolactinemia in antipsychotic drug-treated schizophrenic patients // World J. Biol. Psychiatry.– 2017 Apr;18(3):239-246. (IF 4.159) DOI: 10.1080/15622975.2016.1224926

  5. Ivanova SA, Osmanova DZ, Boiko AS, Pozhidaev IV, Freidin MB, Fedorenko OY, Semke AV, Bokhan NA, Kornetova EG, Rakhmazova LD, Wilffert B, Loonen AJ. Prolactin gene polymorphism (-1149 G/T) is associated with hyperprolactinemia in patients with schizophrenia treated with antipsychotics. Schizophr Res. 2017 Apr;182:110-114. doi: 10.1016/j.schres.2016.10.029 (IF 4.453) https://www.ncbi.nlm.nih.gov/pubmed/27776952

  6. Albert Batalla, Judith R. Homberg, Tatiana V. Lipina, Guillaume Sescousse, Maartje Luijten, Svetlana A. Ivanova, Arnt F.A. Schellekens, Anton J.M. Loonen , The role of the habenula in the transition from reward to misery in substance use and mood disorders Neuroscience & Biobehavioral Reviews Available online 30 May 2017 Volume 80, September 2017, Pages 276–285 https://doi.org/10.1016/j.neubiorev.2017.03.019 (IF 8,55). https://www.ncbi.nlm.nih.gov/pubmed/28576510

  7. Geers LM, Cohen D, Wehkamp LM, van Hateren K, Koster RA, Fedorenko OY, Semke AV, Bokhan N, Ivanova SA, Kosterink JGW, Loonen AJM, Touw DJ. Dried Blood Spot Analysis for Therapeutic Drug Monitoring of Clozapine. J Clin Psychiatry. 2017 Oct 24. pii: 16m11164. doi: 10.4088/JCP.16m11164. (IF 5.291) http://www.psychiatrist.com/JCP/article/Pages/2017/v78n09/16m11164.aspx

  8. Loonen AJM, Ivanova SA. Evolution of circuits regulating pleasure and happiness with the habenula in control. CNS Spectr. 2017 Nov 1:1-6. doi: 10.1017/S1092852917000748. (IF3,589) https://www.ncbi.nlm.nih.gov/pubmed/29091022

  9. Ermakov EA, Smirnova LP, Bokhan NA, Semke AV, Ivanova SA, Buneva VN, Nevinsky GA. Catalase activity of IgG antibodies from the sera of healthy donors and patients with schizophrenia. PLoS One. 2017 Sep 25;12(9):e0183867. doi: 10.1371/journal.pone.0183867. eCollection 2017(IF 2.806) https://www.ncbi.nlm.nih.gov/pubmed/28945759

  10. Loonen AJM, Kupka RW and Ivanova SA (2017) Circuits Regulating Pleasure and Happiness in Bipolar Disorder. Front. Neural Circuits 11:35. doi: 10.3389/fncir.2017.00035 ((IF 3,879) https://www.ncbi.nlm.nih.gov/pubmed/28588455

  11. V. D. Prokopieva, E. G. Yarygina, N. A. Bokhan, and S. A. Ivanova Use of Carnosine for Oxidative Stress Reduction in Different Pathologies. Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 2939087, (IF 4.41) DOI:10.1155/2016/2939087       

  12. I.S. Losenkov, N.M. Vyalova, G.G. Simutkin, N.A. Bokhan, S.A. Ivanova An association of AKT1 gene polymorphism with antidepressant treatment response. The World Journal of Biological Psychiatry 2016 Volume 17, Issue 3, pages 239-242 (IF 4,15) http://dx.doi.org/10.3109/15622975.2015.1112921

  13. Loonen AJM, Ivanova SA (2016) Circuits Regulating Pleasure and Happiness—Mechanisms of Depression. Front. Hum. Neurosci. 10:571. doi: 10.3389/fnhum.2016.00571 (IF 3,634). https://www.ncbi.nlm.nih.gov/pubmed/27891086

  14. Loonen AJ, Ivanova SA. Circuits regulating pleasure and happiness: the evolution of reward-seeking and misery-fleeing behavioral mechanisms in vertebrates. Front Neurosci. 2015 Oct 23;9:394. eCollection 2015. (IF 3,398) http://dx.doi.org/10.3389/fnins.2015.00394

  15. Ermakov EA, Smirnova LP, Parkhomenko TA, Dmitrenok PS, Krotenko NM, Fattakhov NS, Bokhan NA, Semke AV, Ivanova SA, Buneva VN, Nevinsky GA. DNA-hydrolysing activity of IgG antibodies from the sera of patients with schizophrenia. Open Biol. 2015 Sep;5(9):150064. (IF 4,85) DOI: 10.1098/rsob.150064

  16. Ivanova SA, Toshchakova VA, Filipenko ML, Fedorenko OY, Boyarko EG, Boiko AS, Semke AV, Bokhan NA, Aftanas LI, Loonen AJ. Cytochrome P450 1A2 co-determines neuroleptic load and may diminish tardive dyskinesia by increased inducibility. World J Biol Psychiatry. 2015 Apr;16(3):200-5. (IF 4,15) http://dx.doi.org/10.3109/15622975.2014.995222     

  17. Fedorenko O.Y, Loonen A.J.M., Lang F., Toshchakova V.A., Boyarko E.G., Semke A.V., Bokhan N.A., Govorin N.V., Aftanas L.I., Ivanova S.A. Association study indicates a protective role of phosphatidylinositol-4-phosphate-5-kinase against tardive dyskinesia. Int J Neuropsychopharmacol. 2015. 18 (6) p.1-6: (IF 4.333).         DOI: http://dx.doi.org/10.1093/ijnp/pyu098

  18. Ivanova SA, Loonen AJ, Bakker PR, Freidin MB, Ter Woerds NJ, Al Hadithy AF, Semke AV, Fedorenko OY, Brouwers JR, Bokhan NA, van Os J, van Harten PN, Wilffert B. Likelihood of mechanistic roles for dopaminergic, serotonergic and glutamatergic receptors in tardive dyskinesia: A comparison of genetic variants in two independent patient populations. SAGE Open Med. 2016 Apr 11;4:2050312116643673. doi: 10.1177/2050312116643673. http://journals.sagepub.com/doi/pdf/10.1177/2050312116643673

  19. Loonen AJ, Ivanova SA. Circuits regulating pleasure and happiness in major depression. Med Hypotheses. 2016 Feb;87:14-21. (IF 1.07). DOI: 10.1016/j.mehy.2015.12.013

  20. Svetlana A. Ivanova, Anton J. M. Loonen Levodopa-Induced Dyskinesia Is Related to Indirect Pathway Medium Spiny Neuron Excitotoxicity: A Hypothesis Based on an Unexpected Finding, Parkinson’s Disease, vol. 2016, Article ID 6461907, 5 pages, 2016. doi:10.1155/2016/6461907. (IF 2,010). https://www.ncbi.nlm.nih.gov/pubmed/27144051

  21. Ivanova S.A., Geers L.M., Al Hadithy A.F., Pechlivanoglou P., Semke A.V., Vyalova N.M., Rudikov E.V., Fedorenko O.Y., Wilffert B., Bokhan N.A., Brouwers J.R., Loonen A.J. Dehydroepiandrosterone sulphate as a putative protective factor against tardive dyskinesia. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2014 Apr 3; 50: 172-7. (IF 4,361) DOI: 10.1016/j.pnpbp.2013.12.015

  22. Anton J. M. Loonen, Svetlana A. Ivanova New insights into the mechanism of drug-induced dyskinesia. CNS Spectrums 2013 Volume 18   Issue 01 pp 15-20 (IF3,589) DOI: http://dx.doi.org/10.1017/S1092852912000752

  23. Ivanova S.A., Al Hadithy A.F., Brazovskaya N., Semke A., Wilffert B., Fedorenko O., Brouwers J.R., Loonen A.J. No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia. Hum Psychopharmacol. 2012. V. 27. N. 3. P. 334—337. (IF 2,44) DOI: 10.1002/hup.2226

  24. Ivanova S. A., Loonen A. J. M., Pechlivanoglou P., Freidin M. B., Al Hadithy A. F. Y, Rudikov E. V., Zhukova I. A., Govorin N. V., Sorokina V. A., Fedorenko O., Alifirova V. M., Semke A. V., Brouwers J. R. B. J., Wilffert B. NMDA receptor genotypes associated with the vulnerability to develop dyskinesia. Transl Psychiatry. 2012 Jan 10;2:e67 (IF 5,538). DOI: 10.1038/tp.2011.66 http://www.nature.com/tp/journal/v2/n1/full/tp201166a.html

  25. Al Hadithy A. F. Y., Ivanova S. A., Pechlivanoglou P., Semke A., Fedorenko O., Kornetova E., Ryadovaya L., Brouwers J. R. B. J., Loonen A. J. M. Missense polymorphisms in three oxidative-stress enzymes (GSTP1, SOD2, and GPX1) and dyskinesias in Russian psychiatric inpatients from Siberia. Hum. Psychopharmacol. Clin. ExP. 2010. V. 25. N. 1. P. 84—91 (IF 2,44). DOI: 10.1002/hup.1087

  26. Hadithy A.F.Y. Al, Ivanova S.A., Pechlivanoglou P., Semke A., Fedorenko O., Kornetova E., Ryadovaya L., Brouwers J.R.B.J., Wilffert B., Bruggeman R., Loonen A.J.M. Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia// Progress in Neuro-Psychopharmacology & Biological Psychiatry.- 2009.- N.33.- P. 475–481. (IF 4.361). DOI: 10.1016/j.pnpbp.2009.01.010

  27. Fedorenko O., Tang C., Sopjani M., Föller M., Gehring E.-M., Strutz-Seebohm N., Ureche O.N., Ivanova S., Semke A., Lang F., Seebohm G., Lang U.E. PIP5K2A-dependent regulation of excitatory amino acid transporter EAAT3 // Psychopharmacology.- 2009.- V.206.- N3- P429-435. (IF 3.540). DOI: 10.1007/s00213-009-1621-5