Daria I. Zhigalina
Daria I. Zhigalina , PhD, researcher of Laboratory of genomics of orphan disease of Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian FederationContact details
e-mail: darya.zhigalina@medgenetics.ru
Web of Science ResearcherID: R-8362-2016
https://publons.com/researcher/2181085/daria-ivanovna-zhigalina/
Scopus AuthorID: 56957157500
https://www.scopus.com/authid/detail.uri?authorId=56957157500
ORCID: 0000-0003-2800-8875
http://orcid.org/0000-0003-2800-8875
РИНЦ AuthorID: 7606-4447
https://elibrary.ru/author_profile.asp?authorid=894857
Brief Biography
In 2012 she graduated from the National Research Tomsk State University (TSU), receiving a bachelor's degree in biology. In 2014, Daria received a master's degree in biology in TSU. From 2014 to 2018, she studied in graduate school at Tomsk State University with a degree in genetics. In 2018 she defended her thesis on the topic “Comparative cytogenetics of embryoblasts, trophoblasts and blastocoel fluid of the human blastocyst”.
Research Interests
Cytogenetics of human preimplantation development. IPSC
Main Publications
2. Skryabin N.A., Lebedev I.N., Artukhova V.G., Zhigalina D.I., Stepanov I.A. , Krivoschekova G.V., Svetlakov A.V. Molecular karyotyping of cel-free DNA from blastocoele fluid as a basis for noninvasive preimplantation genetic screening of aneuploidy // Russian Journal of Genetics. – 2015. – V. 51. – № 11. – P. 1123–1128.
3. Tolmacheva E.N., Vasilyev S.A., Sazhenova E.A., Zhigalina D.I., Grigorovich E.I., Nikitina T.V., Melnikov A.A., Zhabina E.S., Ivanova T.V., Evtushenko I.D., Lebedev I.N. Skewed X-chromosome inactivation in human miscarriages // Cell and Tissue Biology. – 2016. – V. 10. – № 1. – P. 55–59.
4. Scryabin N.A., Zhigalina D.I., Artyukhova V.G., Svetlakov A.V., Lebedev I.N. Informative blastocentesis in the evaluation of chromosomal mosaicism in the blastocyst stage // Medical Genetics. – V. 15. – № 5. – P. 35–38.
5. Vasiliev S.A., Urazova A.S., Nikitina T.V., Sazhenova E.A., Tolmacheva E.N., Agab A.V., Zhigalina D.I., Lebedev I.N. The frequency of the loss of chromosomal fragments or entire chromosomes in fibroblasts, extraembryonic mesoderm of spontaneous abortions with aneuploidy and triploidy // Medical Genetics. – V. 15. – № 4. – P. 14-17.
6. Zhigalina D.I., Scriabin N.A., Artyukhova V.G., Svetlakov A.V., Lebedev I.N. Distribution reciprocal aneuploidies on preimplantation stage of development on the basis of the data of molecular karyotyping extracellular DNA blastocyst // Medical Genetics. – V. 15. – № 4. – P. 39-43.
7. Tšuiko O., Zhigalina D.I., Jatsenko T., Skryabin N.A., Kanbekova O.R., Artyukhova V.G., Svetlakov A.V., Teearu K., Trošin A, Salumets А., Kurg A., Lebedev I.N. The karyotype of the blastocoel fluid demonstrates low concordance with both trophectoderm and inner cell mass // Fertility and Sterility. – 2018. – V. 109. – № 6. – P. 1127–1134e1.
8. Zhigalina D.I., Skryabin N.A., Kanbekova O.R., Maroshkina А.N., Churkin Е.О., Lebedev I.N. The structure of chromosomal abnormalities in the cycles of IVF-PGD // Medical Genetics. 2019. – Т. 18. – № 3. – С. 47-54.
9. Kashevarova A.A., Skryabin N.A., Nikitina T.V., Lopatkina M.E., Sazhenova E.A., Zhigalina D.I., Savchenko R.R., Lebedev I.N. Ontogenetic Pleiotropy of Genes Involved in CNVs in Human Spontaneous Abortions // Russian Journal of Genetics. – 2019. – V. 55. – № 10. – P. 1214-1226.
10. Skryabin N.A., Vasilyev S.A., Nikitina T.V., Zhigalina D.I., Savchenko R.R., Babushkina N.P., Lopatkina M.E., Kashevarova A.A., Lebedev I.N. Runs of homozygosity in spontaneous abortions from families with recurrent pregnancy loss // Vavilov Journal of Genetics and Breeding. – 2019.– V. 23. – №. 2. – P. 244-249.
11. Zhigalina D.I., Skryabin N.A., Vasilieva O.Y., Lopatkina M.E., Vasiliev S.A., Sivokha V.M., Belyaeva E.O., Savchenko R.R., Nazarenko L.P., Lebedev I.N. FISH diagnostics of chromosomal translocation with the technology of synthesis of locus-specific DNA probes based on long-range PCR// Russian Journal of Genetics. – 2020. – V. 56. – №. 6. – P. 739-746
12. Nikitina T.V., Sazhenova E.A., Zhigalina D.I., Tolmacheva E.N., Sukhanova N.N., Lebedev I.N. Karyotype evaluation of repeated abortions in primary and secondary recurrent pregnancy loss // Journal of Assisted Reproduction and Genetics. – 2020. – P. 1-9.
13. Zhigalina D.I., Malakhova A.A., Vasilyeva O.Yu., Grigor'eva E.V., Sivtcev A.A., Kolesnikov N.A., Lopatkina M.E., Savchenko R.R., Zhalsanova I.Zh., Postrigan’ A.E., Zarubin A.A, Nikitina T.V., Bueverov A.O., Bogomolov P.O., Zakian S.M., Skryabin N.A. Generation of an induced pluripotent stem cell line ICGi030-A from a male patient with Wilson's disease carrying a frameshift mutation p.Lys1013fs and missense mutation p.H1069Q in the ATP7B gene // Stem Cell Research. –2021. – V. 57. – P. 102556.
14. Vasilyev S.A., Tolmacheva E.N., Vasilyeva O.Y., Markov A.V., Zhigalina D.I., Zatula, L. A., ... & Lebedev, I. N. LINE-1 retrotransposon methylation in chorionic villi of first trimester miscarriages with aneuploidy // Journal of Assisted Reproduction and Genetics, 2021. 38(1), 139-149.
15. Lebedev, I. N., Karamysheva, T. V., Elisaphenko, E. A., Makunin, A. I., Zhigalina, D. I., Lopatkina, M. E., ... & Rubtsov, N. B. (2021). Prenatal Diagnosis of Small Supernumerary Marker Chromosome 10 by Array-Based Comparative Genomic Hybridization and Microdissected Chromosome Sequencing. Biomedicines, 9(8), 1030.
16. Vasilyev, S. A., Markov, A. V., Vasilyeva, O. Y., Tolmacheva, E. N., Zatula, L. A., Sharysh, D. V., Zhigalina, D. I... & Lebedev, I. N. (2021). Method of targeted bisulfite massive parallel sequencing of the human LINE-1 retrotransposon promoter. MethodsX, 8, 101445.
17. Lebedev, I.N., Zhigalina D.I., From contemplation to classification of chromosomal mosaicism in human preimplantation embryos // Journal of Assisted Reproduction and Genetics // 2021. – V. 38. – №. 11. – P. 2833-2848. – https://doi.org/10.1007/s10815-021-02304-z.
18. Zhigalina D.I., Malakhova A.A., Vasilyeva O.Yu., Grigor'eva E.V., Sivtcev A.A., Kolesnikov N.A., Lopatkina M.E., Savchenko R.R., Zhalsanova I.Zh., Postrigan’ A.E., Zarubin A.A, Nikitina T.V., Bueverov A.O., Bogomolov P.O., Zakian S.M., Skryabin N.A. Generation of an induced pluripotent stem cell line ICGi030-A from a male patient with Wilson's disease carrying a frameshift mutation p.Lys1013fs and missense mutation p.H1069Q in the ATP7B gene // Stem Cell Research. –2021. – V. 57. – P. 102556.