Personalities

Brief Biography

MSc, 1995, Siberian State Medical University (Russia), Pharmaceutical Faculty; PhD, 2005 (PhD-thesis in the field of Medical Genetics: The comparative analysis of structure hereditary components of susceptibility to atopic bronchial asthma and tuberculosis on genes of xenobiotic-metabolising enzymes. Supervisor: Prof. Valery Puzyrev), The Research Institute of Medical Genetics.

Degrees: MSc, 1995, Siberian State Medical University (Russia), Pharmaceutical Faculty;

PhD, 2005 (PhD-thesis in the field of Medical Genetics: The comparative analysis of structure hereditary components of susceptibility to atopic bronchial asthma and tuberculosis on genes of xenobiotic-metabolising enzymes. Supervisor: Prof. Valery Puzyrev), The Research Institute of Medical Genetics.

Research Interests

Genetics and genomics of common diseases (asthma, tuberculosis and etc), in particular the approaches and tools for analysis of co-morbid diseases.
Functional polymorphism of human genome.

PRESENT RESEARCH:

• Genetics and genomics of common diseases (asthma, tuberculosis and etc), in particular the approaches and tools for analysis of co-morbid diseases.
• Functional polymorphism of human genome.

Achievements, awards, and grants

I've been involved in grants of domestic and foreign funds, including The Russian Foundation for Basic Research, the Russian Scientific Fund, the President’s Grant for the Leading Scientific Schools of Russian Federation, SIXTH FRAMEWORK PROGRAMME, Volkswagen Stiftung and etc.

RESEARCH GRANTS PARTICIPATION:

I've been involved in grants of domestic and foreign funds, including The Russian Foundation for Basic Research, the Russian Scientific Fund, the President’s Grant for the Leading Scientific Schools of Russian Federation, SIXTH FRAMEWORK PROGRAMME, Volkswagen Stiftung and etc.

Main Publications

1. Bragina EY, Goncharova IA, Garaeva AF, Nemerov EV, Babovskaya AA, Karpov AB, Semenova YV, Zhalsanova IZ, Gomboeva DE, Saik OV, Zolotareva OI, Ivanisenko VA, Dosenko VE, Hofestaedt R, Freidin MB. Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases. J Integr Bioinform. 2018 Dec 10. DOI: 10.1515/jib-2018-0052


2. Drevytska T, Morhachov R, Tumanovska L, Portnichenko G, Nagibin V, Boldyriev O, Lapikova-Bryhinska T, Gurianova V, Dons'koi B, Freidin M, Ivanisenko V, Bragina EY, Hofestädt R, Dosenko V. shRNA-Induced Knockdown of a Bioinformatically Predicted Target IL10 Influences Functional Parameters in Spontaneously Hypertensive Rats with Asthma. J Integr Bioinform. 2018 Dec 10. DOI: https://doi.org/10.1515/jib-2018-0053.


3. Bragin AO, Sokolov VS, Demenkov PS, Ivanisenko TV, Bragina EYu, Matushkin YuG, Ivanisenko VA. Prediction of Bacterial and Archaeal Allergenicity with AllPred Program // Molecular Biology. 2018. 52 (2), 279-284.


4. Saik OV, Demenkov PS, Ivanisenko TV, Bragina EY, Freidin MB, Goncharova IA, Dosenko VE, Zolotareva OI, Hofestaedt R, Lavrik IN, Rogaev EI, Ivanisenko VA. Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks // BMC Medical Genomics. – 2018. - 11 (Suppl 1) :15. https://doi.org/10.1186/s12920-018-0331-4


5. Babushkina NP, Bragina EYu, Garaeva AF, Goncharova IA, Rudko AA, Tcitrikov DYu, Gomboeva DE, FreidinMB. Validation of the Results of Genome-Wide Association Studies of Tuberculosis in Russians of West Siberia // Russian Journal of Genetics. – 2018. – 54(1). – P. 103-109.


6. Vonk JM, Scholtens S, Postma DS, Moffatt MF, Jarvis D, Ramasamy A, Wjst M, Omenaas ER, Bouzigon E, Demenais F, Nadif R, Siroux V, Polonikov AV, Solodilova M, Ivanov VP, Curjuric I, Imboden M, Kumar A, Probst-Hensch N, Ogorodova LM, Puzyrev VP, Bragina EY, Freidin MB, Nolte IM, Farrall AM, Cookson WO, Strachan DP, Koppelman GH, Boezen HM. Adult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortium // PLoS One. 2017;12(3):e0172716. doi: 10.1371/journal.pone.0172716.


7. Rudko A.A., Bragina E.Yu., V.P. Puzyrev, Freidin M.B. The genetics of susceptibility to tuberculosis: Progress and challenges // Asian Pacific Journal of Tropical Disease. - 2016. - 6(9). - P. 680-684. doi: 10.1016/S2222-1808(16)61109-X


8. Garaeva A.F., Babushkina N.P., Rudko A.A., Goncharova I.A., Bragina E.Yu., Freidin M.B. Differential genetic background of primary and secondary tuberculosis in Russians // Meta Gene. - 2016. - 11. - P. 178–180. http://dx.doi.org/10.1016/j.mgene.2016.10.008


9. Bragina E.Yu., Tiys E.S., Rudko A.A., Ivanisenko V.A., Freidin M.B. Novel tuberculosis susceptibility candidate genes revealed by the reconstruction and analysis of associative networks // Infection, Genetics and Evolution. – 2016. – 46. – P. 118-123. http://dx.doi.org/10.1016/j.meegid.2016.10.030http://dx.doi.org/10.1016/j.meegid.2016.10.030


10. Rudko A.A., Garaeva A.F., Bragina E.Yu., Babushkina N.P., Kolokolova O.V., Lipaenkova O.N., Freidin M.B., Puzyrev V.P. Mutations in genes underlying atypical familial mycobacteriosis are not found in tuberculosis patients from Siberian populations // Tuberculosis (Edinb). – 2015. - 95(2). – P. 204-207. http://dx.doi.org/10.1016/j.tube.2015.01.002.


11. Bragina E.Yu., Tiys E.S., Freidin M.B., Koneva L.A., Demenkov P.S., Ivanisenko V.A., Kolchanov N.A., Puzyrev V.P. Insights into pathophysiology of dystropy through the analysis of gene networks: an example of bronchial asthma and tuberculosis // Immunogenetics. – 2014. – V. 66(7-8). – P. 457-465. doi: 10.1007/s00251-014-0786-1.


12. Saltykova I.V., Ogorodova L.M., Bragina E.Y., Puzyrev V.P., Freidin M.B. Opisthorchis felineus liver fluke invasion is an environmental factor modifying genetic risk of atopic bronchial asthma // Acta Trop. – 2014. - V. 139. – P. 53-56. doi: 10.1016/j.actatropica.2014.07.004.


13. Freidin MB, Bragina EYu, Saltykova IV, Deeva EV, Ogorodova LM, Puzyrev VP. Effect of additional disease (Comorbidity) on association of allergic rhinitis with KCNE4 gene rs12621643 variant // Russian Journal of Genetics. – 2013. - 49(4). – P. 473-475. DOI: 10.1134/S1022795413040054


14. Scholtens S, Postma DS, Moffatt MF, Panasevich S, Granell R, Henderson AJ, Melén E, Nyberg F, Pershagen G, Jarvis D, Ramasamy A, Wjst M, Svanes C, Bouzigon E, Demenais F, Kauffmann F, Siroux V, von Mutius E, Ege MJ, Braun-Fahrländer C, Genuneit J; GABRIELA study group, Brunekreef B, Smit HA, Wijga AH, Kerkhof M, Curjuric I, Imboden M, Thun GA, Probst-Hensch N, Freidin MB, Bragina EI, Deev IA, Puzyrev VP, Daley D, Park J, Becker A, Chan-Yeung M, Kozyrskyj AL, Pare P, Marenholn I, Lau S, Keil T, Lee YA, Kabesch M, Wijmenga C, Franke L, Nolte IM, Vonk J, Kumar A, Farrall M, Cookson WO, Strachan DP, Koppelman GH, Boezen HM. Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure // Journal of Allergy and Clinical Immunology. – 2013. – V. 132(6). – P. 27A–28A. doi: 10.1016/j.jaci.2013.08.049.


15. Freidin MB, Bragina EYu, Fedorova OS, Deev IA, Kulikov ES, Ogorodova LM, Puzyrev VP. Genome-wide association study of allergic diseases in Russians of West Siberia// Molecular Biology. – 2011. – 45: 421. https://doi.org/10.1134/S0026893311020075


16. Moffatt M.F., Gut I.G., Demenais F. et GABRIEL consortium A large-scale, consortium-based genomewide association study of asthma // N Engl J Med. – 2010. – V. 363. – P. 1211-1221.