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Igor N. Lebedev

Igor N. Lebedev

Igor N. Lebedev, Doctor of Biological Sciences, a Professor of the Russian Academy of Sciences, Deputy Director for Science of the Tomsk National Research Medical Center, Deputy Director for Science of the Research Institute of Medical Genetics of TNRMC, Head of the Laboratory of Cytogenetics.

Contact details

tel.: +7 (3822) 51-11-09
Fax: +7 (3822) 51-37-44

Brief Biography

Igor Lebedev was born in 1974. He was graduated with honours from the Tomsk State University, Department of Biology and Soil Science, Chair of Cytology and Genetics with a master's degree in Biology in 1998. From 1998 till 2001 I.N. Lebedev was a PhD student of the Research Institute of Medical Genetics under scientific supervising of Professor Sergey Nazarenko. Since 2001 he had been working as a researcher of the Laboratory of Cytogenetics, which he has been leading since 2005. I.N. Lebedev defended his PhD thesis in 2001 and a dissertation for the degree of a Doctor of Biological Sciences in specialty «Genetics» in 2008. Since 2015 he is the Deputy Director for Science of the Research Institute of Medical Genetics. Dr. Lebedev received the title of a Professor of RAS in 2016. Since 2020 he is the Deputy Director for Science of the Tomsk National Research Medical Center.

Research Interests

Basic studies of Prof. Lebedev are related to research of cytogenetics of human development, mechanisms of chromosomal abnormalities origin and investigation of its role in the pathogenesis of chromosomal diseases. Guided by Prof. Lebedev studies are concerned with the developing of molecular cytogenetic methods for diagnosis of chromosomal disorders and implementing such techniques into healthcare practices.
Prof. Lebedev is an author and co-author of more than 600 publications, including two editions of «National guideline: Hereditary diseases» (M.: GEOTAR-Media, 2012, 2017), monographs «Regenerative biology and medicine» (Omsk – Moscow – Tomsk, 2012, 2015, 2017), «Cytogenetic effects of radiation and chemical effects on a person» (Tomsk, 2014), «Head and neck squamous cell carcinoma: Molecular basis of pathogenesis» (M.: Nauka, 2016), «Aneuploidy» (Karger, 2011), «Epigenetics and Epigenomics» (InTech, 2014), «Genetic information in practice» (Zagreb, 2016). Nine PhD and two Doctor’s degree theses were defended under scientific supervising of Prof. Lebedev.

Achievements, awards, and grants

Several Russian and international research projects focused on the analysis of human genome variability in intellectual disability, pregnancy loss, and oncological diseases were realized under the guidance of Prof. Lebedev. A number of novel chromosomal abnormalities in miscarriages have been described; molecular and cytogenetic mechanisms of chromosomal abnormalities origin during early stages of embryo development have been investigated; a classification of mosaic forms of chromosomal abnormalities has been introduced. The role of epigenetic mechanisms, like genomic imprinting and X-chromosome inactivation, in the pathogenesis of spontaneous and recurrent pregnancy loss was established. Advanced molecular technologies of prenatal and preimplantation genetic diagnostics of chromosomal diseases have been developed and implemented into the practice of national health-care system.
Prof. Lebedev had been a coordinator of the EU Seventh Framework Programme Project «Improving Diagnoses of Mental Retardation in Children in Central Eastern Europe and Central Asia Through Genetic Characterization and Bioinformatics/Statistics» from the Russian side, at which the role of copy number variations (CNV) in the aetiology of idiopathic intellectual disability has been investigated. A number of novel CNVs associated with intellectual development delay have been described. For the first time, cellular models of diseases based on induced pluripotent stem cells lines of patients with intellectual disability and chromosomal abnormalities have been designed.
A series of cytogenetic studies of workers in nuclear industry has been held under the guidance of Prof. Lebedev.
Prof. Lebedev participates in organization and realization of scientific studies with the support of national and international science foundations: the Russian Science Foundation, the Russian Foundation for Basic Research, the Grant of the President of the Russian Federation, the Federal Aimed Programmes, the EU Seventh Framework Programme.
Prof. Lebedev is a Member of the Dissertation Council (D. 002.279.04).He is also a Member of the Academic Council of the Tomsk National Research Medical Centre of the Russian Academy of Sciences and the Academic Council of the Research Institute of Medical Genetics of TNRMC.
Prof. Lebedev is a Member of the Presidium of the Executive Board of the Russian Society of Medical Geneticists, a Member of the Vavilov’s Society of Geneticists and Breeders, the European Cytogeneticists Association, the European Society of Human Genetics, the European Society of Human Reproduction and Embryology. He is an expert of the Russian Science Foundation. 

Prof. Igor Lebedev is a member of the Editorial Board of the Vavilov Journal of Genetics and Breeding and the Journal of Assisted Reproduction and Genetics.

Scientific achievements of Prof. Lebedev have been marked with Certificates of Merit of the Healthcare Committee of the State Duma of the Russian Federation, the Tomsk Region Government, the Siberian Branch of RAMS, the Tomsk Scientific Centre of Siberian Branch of RAMS and professional associations. Prof. Lebedev was awarded the title of Laureate of the Tomsk Region in education, science, healthcare and culture in the nomination «Awards to scientific workers and teachers for significant individual impact in science and education development» in 2016.

Web of Science ResearcherID: K-7454-2012

Scopus AuthorID: 7103250270

ORCID: 0000-0002-0482-8046 

РИНЦ AuthorID: 96322

Monographs and textbook:

1.           Lebedev I.N. Cytogenetika probačaja (Cytogenetics of spontaneous abortions) / Genetičko informiranje u praksi (Genetic information in practice) (Eds. Čulič V., Pavelič J., Radman M.) / Zagreb.: Medicinska Naklada, 2016. 295 p. 

2.           Lebedev I.N. Genomic imprinting and human reproduction // Epigenomics and Epigenetics. InTech. 2014.

Main Publications

1.           Nikitina T.V., Sazhenova E.A., Zhigalina D.I., Tolmacheva E.N., Sukhanova N.N., Lebedev I.N. Karyotype evaluation of repeated abortions in primary and secondary recurrent pregnancy loss // J. Assist. Reprod. Genet. 2020 37(3): 517-525.  doi: 10.1007/s10815-020-01703-y

2.           Fedorenko O.Yu., Golimbet V.E., Ivanova S.A., Levchenko A., Gainetdinov R.R., Semke A.V., Simutkin G.G., Gareeva A.E., Glotov A.G., Gryaznova A., Iourov I.Yu., Krupitsky E.M., Lebedev I.N., Mazo G.E., Kaleda V.G., Abramova L.I., Oleichik I.V., Nasykhova Yu.A., Nasyrova R.F., Nikolishin A.E., Kasyanov E.D., Rukavishnikov G.V., Timerbulatov I.F., Brodyansky V.M., Vorsanova S.G., Yurov Yu.B., Zhilyaeva T.V., Sergeeva A.V., Blokhina E.A., Zvartau E.E., Blagonravova A.S., Aftanas L.I., Bokhan N.A., Kekelidze Z.I., Klimenko T.P., Anokhina I.P., Khusnutdinova E.K., Klyushnik T.P., Neznanov N.G., Stepanov V.A., Schulze T.G., Kibitov A.O. Opening up new horizons for psychiatry genetics in the Russian Federation: moving toward a national consortium // Molecular Psychiatry. 2019 Aug;24(8):1099-1111. doi: 10.1038/s41380-019-0354-z

3.           Shnaider TA, Pristyazhnyuk IE, Menzorov AG, Matveeva NM, Nikitina TV, Khabarova AA, Skryabin NA, Kashevarova AA, Lopatkina ME, Nazarenko LP, Lebedev IN, Serov OL. Generation of four IPSC lines from two siblings with a microdeletion at the CNTN6 gene and intellectual disability // Stem Cell Res. 2019 41:101591 doi: 10.1016/j.scr.2019.101591

4.           Gridina MM, Nikitina TV, Pristyazhnyuk IE, Kashevarova AA, Lopatkina ME, Vasilyev SA, Nazarenko LP, Lebedev IN, Serov OL. Generation of the induced pluripotent stem cell line, ICAGi002-A, from unaffected carrier of megabase scaled duplication involving the CNTN6 gene // Stem Cell Res. 2019 40:101556. doi: 10.1016/j.scr.2019.101556

5.           Kashevarova A.A., Nazarenko L.P., Skryabin N.A., Nikitina T.V., Vasilyev S.A., Tolmacheva E.N., Lopatkina M.E., Salyukova O.A., Chechetkina N.N., Vorotelyak E.A., Kalabusheva E.P., Fishman V.S., Kzhyshkowska J., Graziano C., Magini P., Romeo G., Lebedev I.N. A mosaic intragenic microduplication of LAMA1 and a constitutional 18p11.32 microduplication in a patient with keratosis pilaris and intellectual disability // Am J Med Genet A. 2018 Sep 23. doi: 10.1002/ajmg.a.40478.

6.           Čulić V., Lasan-Trcić R., Liehr T., Lebedev I.N., Pivić M., Pavelic J., Vulić R. A familial small supernumerary marker chromosome 15 associated with cryptic mosaicism with two different additional marker chromosomes derived de novo from chromosome 9: Detailed case study and implications for recurrent pregnancy loss // Cytogenet. Genome Res. 2018. 156(4): 179-184. doi: 10.1159/000494822

7.           Gridina M.M, Matveeva N.M., Fishman F.S., Menzorov A.G., Kizilova H.A., Beregovoy N.A., Kovrigin I.I., Pristyazhnyuk I.E., Oscorbin I.P., Filipenko M.L., Kashevarova A.A., Skryabin N.A., Nikitina T.V., Sazhenova E.A., Nazarenko L.P., Lebedev I.N., Serov O.L. Allele-Specific Biased Expression of the CNTN6 Gene in iPS Cell-Derived Neurons from a Patient with Intellectual Disability and 3p26.3 Microduplication Involving the CNTN6 Gene // Molecular Neurobiology. 2018. V. 55. № 8. P. 6533-6546.

8.           Tšuiko O., Zhigalina D.I., Jatsenko T., Skryabin N.A., Kanbekova O.R., Artyukhova V.G., Svetlakov A.V., Teearu K., Trošin A, Salumets А., Kurg A., Lebedev I.N. The karyotype of the blastocoel fluid demonstrates low concordance with both trophectoderm and inner cell mass // Fertility and Sterility. 2018. V. 109. № 6. P. 1127–1134е1. doi: 10.1016/j.fertnstert.2018.02.008

9.           Kashevarova A.A., Belyaeva E.O., Nikonov A.M., Plotnikova O.V., Skryabin N.A., Nikitina T.V., Vasilyev S.A., Yakovleva Y.S., Babushkina N.P., Tolmacheva E.N., Lopatkina M.E., Savchenko R.R., Nazarenko L.P., Lebedev I.N. Compound phenotype in a girl with r(22), concomitant microdeletion 22q13.32-q13.33 and mosaic monosomy 22 // Molecular Cytogenetics. 2018. 11:26. doi: 10.1186/s13039-018-0375-3

10.        Nikitina T.V., Menzorov A.G., Kashevarova A.A., Gridina M.M., Khabarova A.A., Yakovleva Y.S., Lopatkina M.E., Kizilova E.A., Vasilyev S.A., Serov O.L., Lebedev I.N. Generation of two iPSC lines (IMGTi001-A and IMGTi001-B) from human skin fibroblasts with ring chromosome 22 // Stem Cell Res. 2018 31:244-248. doi: 10.1016/j.scr.2018.08.012.

11.        Nikitina T.V., Menzorov A.G., Kashevarova A.A., Gridina M.M., Khabarova A.A., Yakovleva Y.S., Lopatkina M.E., Pristyazhnyuk I.E., Vasilyev S.A., Serov O.L., Lebedev I.N. Induced pluripotent stem cell line, IMGTi003-A, derived from skin fibroblasts of an intellectually disabled patient with ring chromosome 13 // Stem Cell Res. 2018 33:260-264. doi: 10.1016/j.scr.2018.11.009..

12.        Nazarenko M.S., Sleptcov A.A., Lebedev I.N., Skryabin N.A., Markov A.V., Golubenko M.V., Koroleva I.A., Kazancev A.N., Barbarash O.L., Puzyrev V.P. Genomic structural variations for cardiovascular and metabolic comorbidity // Scientific Reports. 2017. 7:41268. doi:10.1038/srep41268

13.        Lebedev I.N., Nazarenko L.P., Skrayabin N.A., Babushkina N.P., Kashevarova A.A. A de novo microtriplication at 4q21.21-q21.22 in a patient with a vascular malignant hemangioma, elongated sigmoid colon, development delay, and absence of speech // American Journal of Medical Genetics. Part A. 2016. V. 170A. № 8. P. 2089-2096. DOI: 10.1002/ajmg.a.37754 

14.        Nikitina T.V., Sazhenova E.A., Tolmacheva E.N., Sukhanova N.N., Kashevarova A.A., Skryabin N.A., Vasilyev S.A., Nemtseva T.N., Yuriev S.Y., Lebedev I.N. Comparative cytogenetic analysis of spontaneous abortions in recurrent and sporadic pregnancy losses // Biomedicine Hub. 2016. 1:446099. DOI: 10.1159/000446099

15.        Nazarenko M.S., Markov A.V., Lebedev I.N., Freidin M.B., Sleptcov A.A., Koroleva I.A., Frolov A.V., Popov V.A., Barbarash O.L., Puzyrev V.P. A comparison of genome-wide DNA methylation patterns between different vascular tissues from patients with coronary heart disease // PloS ONE. 2015. 10(4): e0122601. DOI:10.1371/journal.pone.0122601

16.        Denisov E.V., Skryabin N.A., Vasilyev S.A., Gerashchenko T.S., Lebedev I.N., Zavyalova M.V., Cherdyntseva N.V., Perelmuter V.M. Relationship between morphological and cytogenetic heterogeneity in invasive micropapillary carcinoma of the breast: a report of one case // Journal of Clinical Pathology. 2015. V. 68. № 9. P. 758-762. DOI:10.1136/jclinpath-2015-203009

17.        Kashevarova A.A., Nazarenko L.P., Schultz-Pedersen S., Skryabin N.A., Salyukova O.A., Chechetkina N.N., Tolmacheva E.N., Rudko A.A., Magini P.,  Graziano C., Romeo G., Joss Sh., Tümer Z., Lebedev I.N. Single gene microdeletions and microduplication of 3p26.3 in three unrelated families: CNTN6 as a new candidate gene for intellectual disability // Molecular Cytogenetics. 2014. 7:97. DOI: 10.1186/s13039-014-0097-0

18.        Melnikov A.A., Musabaeva L.I., Velikaya V.V., Gribova O.V., Startseva Z.A., Urazova L.N., Choynzonov E.L., Vasilyev S.A., Lebedev I.N. Cytogenetic effects of neutron therapy in patients with parotid gland tumors and relapse of breast cancer // Experimental Oncology. 2012. V. 34. №. 4. P. 354-357

19.        Kashevarova A.A., Nazarenko L.P., Skryabin N.A., Salyukova O.A., Chechetkina N.N., Tolmacheva E.N., Sazhenova E.A., Magini P., Graziano C., Romeo G., Kučinskas V., Lebedev I.N. Array CGH analysis of a cohort of Russian patients with intellectual disability // Gene. 2014. V. 536. № 1. P. 145-150. DOI: 10.1016/j.gene.2013.11.029

20.        Lebedev I. Mosaic aneuploidy in early fetal losses // Cytogenetic and Genome Research. 2011. V. 133. № 2-4. P. 169-183. DOI: 10.1159/000324120

21.        Lebedev I.N., Ostroverkhova N.V., Nikitina T.V., Sukhanova N.N., Nazarenko S.A. Features of chromosomal abnormalities in spontaneous abortion cell culture failures detected by Interphase FISH analysis // European Journal of Human Genetics. 2004. V. 12. № 7. P. 513-520

22.        Lopatkina M.E., Lebedev I.N. Transcriptome analysis as a tool for investigation of pathogenesis of chromosomal diseases // Russian Journal of Genetics. 2020. V. 56(5): 548-561.

23.        Sazhenova E.A., Nikitina T.V., Skryabin N.A., Minaycheva L.I., Ivanova T.V., Nemtseva T.N., Yuriev S. Yu., Evtushenko I.D., Lebedev I.N. Epigenetic status of imprinted genes in placenta during recurrent pregnancy loss // Russian Journal of Genetics. 2017. V. 53. № 3. P. 376-387.

24.        Zhigalina D.I., Skryabin N.A., Artyukhova V.G., Svetlakov A.V., Lebedev I.N. Preimplantation genetic diagnosis by blastocentesis: problems and perspectives // Russian Journal of Genetics. 2016. V. 52. № 1. P. 1-7.

25.        Kashevarova A.A., Lebedev I.N. Genomic architecture of human chromosomal diseases // Russian Journal of Genetics. 2016. V. 52(5). P. 447-462.

26.        Nikitina T.V., Lebedev I.N. Cytogenetics of recurrent pregnancy loss // Russian Journal of Genetics. 2014. V. 50. № 5. P. 435-446.

27.        Sazhenova E.A., Skryabin N.A., Sukhanova N.N., Lebedev I.N. Multilocus epimutations of imprintome in the pathology of human embryo development // Molecular Biology. 2012. V. 46. № 2. P. 183-191.

28.        Lebedev I.N., Sazhenova E.A. Epimutations of imprinted genes in the human genome: classification, causes, association with hereditary pathology // Russian Journal of Genetics. 2008. V. 44. № 10. P. 1176-1190.

29.        Lebedev I.N., Puzyrev V.P. Epigenetic perspectives of safety in assisted reproductive technologies // Russian Journal of Genetics. 2007. V. 43. № 9. P. 961-972.

30.        Lebedev I.N., Nazarenko S.A. Tissue-specific placental mosaicism for autosomal trisomies in human spontaneous abortuses: mechanisms of formation and phenotypical effects // Russian Journal of Genetics. 2001. V. 37. № 11. P. 1224-1237.