Sleptsov Aleksei
Ph.D., Research Associate, Laboratory of Population Genetics, Research Institute of Medical Genetics of Tomsk National Research MedicalCenter, Tomsk, Russia.
Contacts
Phone: +7(3822) 51-72-72
Fax: +7(3822) 51-37-44
e-mail: alexei.sleptcov@medgenetics.ru
e-mail: aslep.tnimc@outlook.com
Short CV
EDUCATION:
8/2004 - 5/2010 M.D., North Eastern Federal University, Yakutsk, Russia.
8/2010 - 5/2012 Residency and Internship, Research Institute of Medical Genetics Siberian Branch of Russian Academy of Medical Science, Tomsk, Russia.
POSTGRADUATE APPOINTMENTS:
2/2012 – 10/2012 Young Research Fellow, Laboratory of Population Genetics, Research Institute of Medical Genetics, Siberian Branch of Russian Academy of Medical Science, Tomsk, Russia.
RESEARCH ACTIVITIES:
11/2012 – 5/2015 Young Research Officer, Laboratory of Population Genetics, Research Institute of Medical Genetics Siberian Branch of Russian Academy of Medical Science, Tomsk, Russia.
6/2015 – present Research Associate, Laboratory of Population Genetics, Research
Institute of Medical Genetics of Tomsk National Research Medical Center, Tomsk, Russia.
PhD PROGRAMM:
9/2015 – 10/2018 Ph.D., Research Institute of Medical Genetics, Tomsk, Russia. “Structural genome variations and cardiovascular continuum”
ACAREMIC DEVELOPMENT:
10/2019 – present Associate Professor, Tomsk State University, Tomsk, Russia.
LANGUAGES: Russian (native), English (advanced).
TRAINING:
1. Basic sequencing and fragment analysis. Applied Biosystems. Moscow. 2010.
2. Summer school "Introduction to statistical genomics". FGBU ISGI SB RAMS. Novosibirsk. 2015
3. Summer school "Intensive for genomic bioinformatics". Institute of Bioinformatics. Moscow. 2016.
4. Advanced training course of medical genetics. VOGiS, Novosibirsk. 2016.
5. Non-contact laser microdissection PALM. Tomsk RSCCP & OOO "Optec". Tomsk. 2017.
6. Preimplantation genetic screening by the NGS method on the Illumina platform. Research Institute of Medical Genetics. Tomsk. 2017.
Research interest
Molecular genetics, genetics of rare and common diseases, bioinformatics.
Achievements, awards and grants
1. Diploma (№ 106), winner of the Little Prize in 2013 for “International Academic Publishing Company” Nauka / Interperiodica for best publication in its journals (November 11, 2014, protocol № 2).
2. The award of Tomsk region in the field of education and science. Prize for scientific and pedagogical teams. Administration of the Tomsk region – 2011.
3. Scholarship of the President of the Russian Federation 2013-2015.
4. Scholarship of the President of the Russian Federation 2016-2018.
5. Diploma of the I degree for the report in the section "Medical and Biological and Agricultural Sciences" at the scientific conference "XIV Laurentian Readings, dedicated to the 110th anniversary of Academician M.A. Lavrentieva "- 2010.
6. Diploma of the I degree for the work presented in the section on biomedical sciences of the scientific conference of students of the Yakutsk State University named after MK. Ammosov – 2010.
7. Diploma for the best scientific work following the results of the open competition of the NEFU in natural, technical and humanitarian sciences. Ministry of Education of the Russian Federation of the FGAOU HPE "NEFU named after M.K. Ammosov "- 2011;
8. Certificate for active scientific activity, FGAOU HPE "NEFU named after M.K. Ammosov "- 2010;
RESEARCH GRANTS:
Title: Methylation status of cyclin-dependent kinase inhibitor genes in
atherogenesis (RFBR 10-04-00674)
Source: The Russian Foundation for Basic Research (RFBR)
Role: Investigator
Dates: 2010 through 2012
Title: Coevolution of human genome and phenotype: genetic diversity of
populations and phenotypic variability of syntropic signs
(contract-02.740.11.0284)
Source: Federal Target Program “Research and development for priority directions
of science and technology complex of Russia for 2007-2013”
Role: Investigator
Dates: 2009 through 2011
Title: The study of the pleiotropic genetic effects in different functional states of
the human organism (contract P-1288)
Source: Federal Target Programme “Scientific and Scientific-Pedagogical
Personnel of the Innovative Russia” for 2009-2013
Role: Investigator
Dates: 2009 through 2011
Title: Design of oligonucleotide biosensors for detection of pharmacogenetic
variants in cardiovascular diseases (contract P-977)
Source: Federal Target Programme “Scientific and Scientific-Pedagogical
Personnel of the Innovative Russia” for 2009-2013
Role: Investigator
Dates: 2009 through 2011
Title: The search for new genetic markers and drug targets of cardiovascular
disease continuum (contract P-713)
Source: Federal Target Programme “Scientific and Scientific-Pedagogical
Personnel of the Innovative Russia” for 2009-2013
Role: Investigator
Dates: 2009 through 2011
Title: Phenomenon of paradominant inheritance of complex diseases
(contract 8062)
Source: Federal Target Programme “Scientific and Scientific-Pedagogical
Personnel of the Innovative Russia” for 2009-2013
Role: Investigator
Dates: 2012 through 2013
Title: Epimutations, paradominant inheritance and atherogenesis
(contract NSh-5096.2014.4)
Source: President Grants for Government Support of the Leading Scientific
Schools of the Russian Federation
Role: Investigator
Dates: 2014 through 2015
Title: Postzygotic variability of nuclear and mitochondrial genome
during atherosclerotic vascular lesions in men
(contract №14-15-00305)
Source: Russian Science Foundation
Role: Investigator
Dates: 2014 through 2016
Title: Comparative analysis of the genetic basis of fibrogenesis in several
human pathological conditions (RFBR 16-04-00840)
Source: The Russian Foundation for Basic Research (RFBR)
Role: Investigator
Dates: 2016 through 2018
Title: Epigenetic mechanisms for regulation of microRNA gene activity
in manifest atherosclerosis in human (contract № 16-15-10150)
Source: Russian Science Foundation
Role: Investigator
Dates: 2016 through 2018
BIBLIOGRAPHY
REFEREED MAIN JOURNAL PUBLICATIONS:
PUBMED AND WEB OF SCIENCE
1. Sleptcov A.A, Nazarenko M.S., Zaitseva A.V., Kazantes A.N., Burkov N.N., Barbarash O.L., Puzyrev V.P. [Somatic mosaicism and structural variations of the GBP3 gene in atherosclerosis]. Atherosclerosis [in Rus]. 2019. V. 15. № 4. P. 46-51.https://doi.org/10.15372/ATER20190404
2. M. S. Nazarenko, A. V. Markov, A. A. Sleptcov, I. A. Koroleva, D. V. Sharysh, A. A. Zarubin, N. R. Valiahmetov, I. A. Goncharova, E. F. Muslimova, M. S. Kuznetsov, B. N. Kozlov, S. A. Afanasiev, V. P. Puzyrev. Comparative Analysis of Gene Expression in Vascular Cells of Patients with Advanced Atherosclerosis. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry. 2019. V. 13. № 1. P. 74-80http://pbmc.ibmc.msk.ru/pdf/PBMC-2018-64-5-416-ru
3. Nazarenko M.S., Sleptcov A.A., Lebedev I.N., Skryabin N.A., Markov A.V., Golubenko M.V., Koroleva I.A., Kazancev A.N., Barbarash O.L., Puzyrev V.P. Genomic structural variations for cardiovascular and metabolic comorbidity. Sci Rep. 2017 Jan 25;7:41268. doi:10.1038/srep41268.https://www.nature.com/articles/srep41268
4. Sleptcov A.A., Nazarenko MS, Kazantsev AN, Burkov NN, Skryabin NA, Krakhmal NV, Tashireva LA, Denisov EV, Lebedev IN, Barbarash OL, Puzyrev VP. Genome-wide copy number profiling of atherosclerotic plaques, European Heart Journal. 2019. V 40, I_Supp. 1. ehz747.0323.https://doi.org/10.1093/eurheartj/ehz747.0323
5. Denisov EV, Schegoleva AA, Gerashchenko TS, Skryabin NA, Sleptcov AA, Yakushina VD, Lyapunova LS, Tuzikov SA, Pankova OV, Perelmuter VM. Gene expression profiling revealed 2 types of bronchial basal cell hyperplasia and squamous metaplasia with different progression potentials // Appl Immunohistochem Mol Morphol. 2019 Mar 20. - doi: 10.1097/PAI.0000000000000762. [Epub ahead of print]. – URL:https://insights.ovid.com/crossref?an=00129039-900000000-98726
6. Denisov EV, Skryabin NA, Gerashchenko TS, Tashireva LA, Wilhelm J, Buldakov MA, Sleptcov AA, Lebedev IN, Vtorushin SV, Zavyalova MV, Cherdyntseva NV & Perelmuter VM. Clinically relevant morphological structures in breast cancer represent transcriptionally distinct tumor cell populations with varied degrees of epithelial-mesenchymal transition and CD44+CD24- stemness. Oncotarget. 2017 May 19.https://www.ncbi.nlm.nih.gov/pubmed/28977854
7. Golubenko M.V., Nazarenko M.S., Frolov A.V., Sleptsov A.A., Markov A.V., Glushkova M.E., Barbarash O.L., Puzyrev V.P. [Analysis of Heteroplasmy in the Major Noncoding Region of Mitochondrial DNA in the Blood and Atherosclerotic Plaques of Carotid Arteries]. Genetika. 2016 Apr;52(4):497-502.https://link.springer.com/article/10.1134/S1022795416040049
8. Nazarenko M.S., Markov A.V., Lebedev I.N., Freidin M.B., Sleptcov A.A., Koroleva I.A., Frolov A.V., Popov V.A., Barbarash O.L., Puzyrev V.P. A comparison of genome-wide DNA methylation patterns between different vascular tissues from patients with coronary heart disease. PLoS One. 2015 Apr 9;10(4):e0122601. doi:10.1371/journal.pone.0122601.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391864/
9. Sleptsov A.A., Nazarenko M.S., Lebedev I.N., Skryabin N.A., Frolov A.V., Popov V.A., Barbarash O.L., Barbarash L.S., Puzyrev V.P. Somatic Genome Variations in Vascular Tissues and Peripheral Blood Leukocytes in Patients with Atherosclerosis. Russian Journal of Genetics. August 2014, Volume 50, Issue 8, pp 870-878.https://link.springer.com/article/10.1134/S1022795414080080
10. Nazarenko M.S., Markov A.V., Lebedev I.N., Sleptsov A.A., Koroleva Y.A., Frolov A.V., Barbarash O.L., Barbarash L.S., Puzirev V.P. Methylation profile of INK4B-ARF-INK4A locus in atherosclerosis. Russian Journal of Genetics. 2013 Jun;49(6):783-7. Russian.http://link.springer.com/article/10.1134%2FS1022795413060070
11. Nazarenko M.S., Markov A.V., Lebedev I.N., Sleptsov A.A., Frolov A.V., Barbash O.L., Puzyrev V.P. DNA methylation profiling of the vascular tissues in the setting of atherosclerosis. Mol Biol (Mosk). 2013 May-Jun;47(3):398-404. Russian.http://link.springer.com/article/10.1134%2FS0026893313030084