Personalities

Vadim A. Stepanov

Vadim A. Stepanov, Full Member of the Russian Academy of Sciences, Doctor of Biological Sciences, Professor, Director of the Tomsk National Research Medical Center, the Head of the Laboratory of Evolutionary Genetics.

Contact details

e-mail: genetics@tnimc.ru
e-mail: vadim.stepanov@medgenetics.ru
Phone: +7(3822)51-22-28
Fax: 8(3822) 51-37-44

Brief Biography

Vadim Anatolyevich Stepanov was graduated from the Tomsk State University, Faculty of Biology and Soil Science/ with a degree in Biology in 1988. In 1989 he was appointed to the position of a junior researcher at the Research Institute of Medical Genetics SB RAS, then he was named to the post of a researcher, and a senior scientific worker after PhD defence in 1995.
During 15 years (from 2000 till 2015) Prof. Stepanov had been holding positions of the Deputy Director of Research and the Head of the Laboratory of Evolutionary Genetics. He defended his doctoral dissertation in 2001. From 2003 till now Vadim Anatolyevich has been working as a Professor of the Department of Cytology and Genetics. He organized a Laboratory of Human Ontogenetics in Tomsk State University in 2014 and still has been leading it. He acquired the title of Professor in 2010. Vadim Anatolyevich Stepanov was elected as the Director of the Research Institute of Medical Genetics of TNRMC in 2016. At the present time he is the Director of the Tomsk National Research Medical Center.

Research Interests

V.A. Stepanov is an author of more than 400 published works, including 13 monographs. He has held 5 patents for an invention. Two doctor’s and thirteen PhD theses were defended under his direction.
The major scientific studies of Prof. Stepanov are related to fundamental research and applications in a field of human populations genetics, genomics and genetics of common diseases and personalized medicine. Under the guidance of V.A. Stepanov, the investigation of cardiovascular diseases genes has been performed and led to the identification of genome variants associated with the Russian population susceptibility to ischemic heart disease and atherosclerosis.
Based on these studies, genetic algorithms and microarray tests have been designed for estimation the risk of certain common diseases developing. In the exploration of human population genetics V.A. Stepanov has carried out the genetic reconstruction of Eurasia territory settlement by Modern Human and genetic diversity in Russian populations.
For the first time in Russia, V.A. Stepanov’s research team has used genetic marker system for population genetics studies. Particularly, the first Russian large-scale population study of the diversity of genetic markers using in forensic science has been conducted. Based on the results of these investigations, a database of Russia and bordering countries population has been created for the aims of DNA identification.

Achievements, awards, and grants

The results of studies led by V.A. Stepanov have been realized in the creation of several databases of forensic science data and genetic test systems and algorithms for estimation of common diseases developing risk, which have been implemented in the Genetic clinic and a number of other organizations.
Guided by V.A. Stepanov studies have been supported by the large number of grants and government contracts, including the Federal Targeted Programme "Research and Development in Priority Development Directions of the Russian Technology Complex", Federal Targeted Programme "Research and scientific-pedagogical personnel of innovative Russia", RFBR and Russian Foundation for Humanities grants, grants of the President of the Russian Federation, EU Seventh Framework Programme, etc.
The achievements of V.A. Stepanov have been marked with the number of prizes and awards, including the second-class medal of the Order of "Merit for the Motherland", commemorative medal "70 Years / Seventieth anniversary of Tomsk Region", prize and medal of the RAMS Presidium in 2002 in the field of fundamental medical studies. V.A. Stepanov was awarded the prize of the Interagency Coordination Committee of the Ministry of Science and Technology Policy of the Russian Federation and the Russian Academy of Sciences for the best work in a field of "Life sciences and biotechnology", which was performed under the State science and technology programme "Human Genome".
Prof. Stepanov has won the Tomsk Region Prize in the area of education and science in the nomination "Awards to scientific workers and teachers for significant individual contribution to science developing". He was rewarded with Certificates of Merit of the Tomsk Region Governor, the Legislative Chamber of the Great Khural of the Tyva Republic, the Presidium of the SB RAMS, the Rector Council of Tomsk Region Universities, and letter of acknowledgement of the Novosibirsk department of the Investigative Committee of the Russian Federation.
V.A. Stepanov carries out significant organizational work. He is a chairman of the Academic Council of the Research Institute of Medical Genetics; a chairman of the joint Academic Council of SB RAS for Medical Sciences; a member of the Academic Council of TNRMC and the vice-head of Dissertation Council (DM.002.279.04) at the TNRMC. Prof. Stepanov is the Deputy Chairman of the Issue Commission "Medical Genetics" of the Interdepartmental Scientific Council for the medical problem of Siberia, Russian Far East and High North.
V.A. Stepanov is a member of organizing committees of conferences, a chairman of sections on Russian scientific forums, an editor of research papers collections and a number of scientific journals (Medical Genetics; The Bulletin of Tomsk State University. Biology; The Vavilov’s Society of Geneticists and Breeders Journal.
V.A. Stepanov is a member of the Vavilov’s Society of Geneticists and Breeders (VSGB), the Russian Society of Medical Genetics, the International Society of Human Genome Research, the European Society of Human Genetics (ESHG). Prof. Stepanov is a member of RFBR Expert Council for "Biology" section, an expert of RAS, RSF and an expert and reviewer of international scientific journals.

Main Publications

The interaction effect of angiogenesis and endothelial dysfunction-related gene variants increases the susceptibility of recurrent pregnancy loss.

Trifonova EA, Swarovskaya MG, Ganzha OA, Voronkova OV, Gabidulina TV, Stepanov VA.

J Assist Reprod Genet. 2019 Jan 24. doi: 10.1007/s10815-019-01403-2. [Epub ahead of print]

Opening up new horizons for psychiatric genetics in the Russian Federation: moving toward a national consortium.

Fedorenko OY, Golimbet VE, Ivanova SА, Levchenko А, Gainetdinov RR, Semke AV, Simutkin GG, Gareeva АE, Glotov АS, Gryaznova A, Iourov IY, Krupitsky EM, Lebedev IN, Mazo GE, Kaleda VG, Abramova LI, Oleichik IV, Nasykhova YA, Nasyrova RF, Nikolishin AE, Kasyanov ED, Rukavishnikov GV, Timerbulatov IF, Brodyansky VM, Vorsanova SG, Yurov YB, Zhilyaeva TV, Sergeeva AV, Blokhina EA, Zvartau EE, Blagonravova AS, Aftanas LI, Bokhan NА, Kekelidze ZI, Klimenko TV, Anokhina IP, Khusnutdinova EK, Klyushnik TP, Neznanov NG, Stepanov VA, Schulze TG, Kibitov АО.

Mol Psychiatry. 2019 Jan 21. doi: 10.1038/s41380-019-0354-z. [Epub ahead of print] Review.

A comprehensive study revealed SNP-SNP interactions and a sex-dependent relationship between polymorphisms of the CYP2J2 gene and hypertension risk.

Polonikov AV, Ponomarenko IV, Bykanova MA, Sirotina SS, Bocharova AV, Vagaytseva KV, Stepanov VA, Azarova IE, Churnosov MI, Solodilova MA.

Hypertens Res. 2019 Feb;42(2):257-272. doi: 10.1038/s41440-018-0142-1. Epub 2018 Dec 5.

[A rare variant in the sortilin-related receptor 1 gene is associated with declined cognitive functions in the elderly].

Stepanov VA, Bocharova AV, Vagaitseva KV, Marusin AV, Markova VV, Minaicheva LI, Zhukova IA, Zhukova NG, Alifirova VM, Makeeva OA.

Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(5):92-95. doi: 10.17116/jnevro20181185192. Russian.

[Association study of genetic markers of schizophrenia and its cognitive endophenotypes].

Bocharova AV, Stepanov VA, Marusin AV, Kharkov VN, Vagaitseva KV, Fedorenko OY, Bokhan NA, Semke AV, Ivanova SA.

Genetika. 2017 Jan;53(1):100-8. Russian.

Frequencies of alleles, genotypes and haplotypes of two polymorphisms in the clusterin gene in the Russian elderly population categorized by cognitive performance.

Bocharova AV, Vagaitseva KV, Makeeva OA, Marusin AV, Stepanov VA.

Data Brief. 2017 Dec 16;16:775-779. doi: 10.1016/j.dib.2017.12.019. eCollection 2018 Feb.

[Detection of novel genetic markers of susceptibility to preeclampsia based on an analysis of the regulatory genes in the placental tissue].

Serebrova VN, Trifonova EA, Gabidulina TV, Bukharina IY, Agarkova TA, Evtushenko ID, Maksimova NR, Stepanov VA.

Mol Biol (Mosk). 2016 Sep-Oct;50(5):870-879. Russian.

[Panel of X-linked single-nucleotide polymorphic markers for DNA identification (XSNPid) based on multiplex genotyping by multilocus PCR and MALDI-TOF mass spectrometry].

Stepanov VA, Vagaitseva KV, Kharkov VN, Cherednichenko AA, Bocharova AV.

Mol Biol (Mosk). 2016 May-Jun;50(3):445-56. doi: 10.7868/S0026898416030150. Russian.

[Evolution of genetic diversity and human diseases].

Stepanov VA.

Genetika. 2016 Jul;52(7):852-64. Review. Russian.

[Haplotype Analysis of Oculopharyngeal Muscular Dystrophy (OPMD) Locus in Yakutia].

Marusin AV, Kurtanov KhA, Maksimova NR, Svarovskaya MG, Stepanov VA.

Genetika. 2016 Mar;52(3):376-84. Russian.

[Prevalence of gene polymorphisms associated with immune-dependent diseases in the populations of North Eurasia].

Cherednichenko AA, Trifonova EA, Vagaitseva KV, Bocharova AV, Varzari AM, Radzhabov MO, Stepanov VA.

Mol Biol (Mosk). 2015 Nov-Dec;49(6):984-92. doi: 10.7868/S002689841506004X. Russian.

[Analysis of Eight Polymorphic Alu Elements in the Teleuts Population].

Swarovskaya MG, Marusin AV, Tacheeva TI, Khitrinskaya IY, Gafarov NI, Stepanov VA.

Genetika. 2015 Aug;51(8):963-6. Russian.

Genomic Study of Cardiovascular Continuum Comorbidity.

Makeeva OA, Sleptsov AA, Kulish EV, Barbarash OL, Mazur AM, Prokhorchuk EB, Chekanov NN, Stepanov VA, Puzyrev VP.

Acta Naturae. 2015 Jul-Sep;7(3):89-99.

[Genetic Variability and Structure of SNP Haplotypes in the DMPK Gene in Yakuts and Other Ethnic Groups of Northern Eurasia in Relation to Myotonic Dystrophy].

Swarovskaya MG, Stepanova SK, Marussin AV, Sukhomyasova AL, Maximova NR, Stepanov VA.

Genetika. 2015 Jun;51(6):724-32. Russian.

[Genetic diversity of X-linked STR-markers in Siberian populations].

Vagaitseva KV, Kharkov VN, Cherpinskaya KV, Khitrinskaya IY, Stepanov VA.

Mol Biol (Mosk). 2015 Mar-Apr;49(2):305-12. Russian.

[Replicative study of susceptibility to childhood-onset schizophrenia in Kazakhs].

Stepanov VA, Bocharova AV, Saduakassova KZ, Marusin AV, Koneva LA, Vagaitseva KV, Svyatova GS.

Genetika. 2015 Feb;51(2):227-35. Russian.

[Replicative association analysis of genetic markers of cognitive traits with Alzheimer's disease in a Russian population].

Stepanov VA, Bocharova AV, Marusin AV, Zhukova NG, Alifirova VM, Zhukova IA.

Mol Biol (Mosk). 2014 Nov-Dec;48(6):952-62. Russian.

[Association of the genenetic polymorphism of cytokines and their receptors with climate and geographic factors in human populations].

Cherednichenko AA, Trifonova EA, Vagaitseva KV, Bocharova AV, Stepanov VA.

Genetika. 2014 Oct;50(10):1254-8. Russian.

[Gene pool of Buryats: clinal variability and territorial subdivision based on data of Y-chromosome markers].

Har'kov VN, Hamina KV, Medvedeva OF, Simonova KV, Eremina ER, Stepanov VA.

Genetika. 2014 Feb;50(2):203-13. Russian.

[Multiplex genotyping of single nucleotide polymorphisms by MALDI-TOF mass-spectrometry: ferequencies of 56 SNP in immune response genes in human populations].

Stepanov VA, Trifonova EA.

Mol Biol (Mosk). 2013 Nov-Dec;47(6):976-86. Russian.

[Biochip for determination of genetic markers of sporadic Alzheimer's disease in the Russian Slavic population].

Nizamutdinov II, Andreeva TV, Stepanov VA, Marusin AV, Rogaev EI, Zasedatelev AS, Nasedkina TV.

Mol Biol (Mosk). 2013 Nov-Dec;47(6):949-58. Russian.

[Gene-pool structure of Tuvinians inferred from Y-chromosome marker data].

Kharkov VN, Khamina KV, Medvedeva OF, Simonova KV, Khitrinskaya IY, Stepanov VA.

Genetika. 2013 Dec;49(12):1416-25. Russian.

Analysis of the placental tissue transcriptome of normal and preeclampsia complicated pregnancies.

Trifonova EA, Gabidulina TV, Ershov NI, Serebrova VN, Vorozhishcheva AY, Stepanov VA.

Acta Naturae. 2014 Apr;6(2):71-83.

[Population frequency and age of c.806C > T mutation in CYB5R3 gene as cause of recessive congenital methemoglobinemia in Yakutia].

Galeeva NM, Voevoda MI, Spiridonova MG, Stepanov VA, Polyakov AV.

Genetika. 2013 Apr;49(4):523-30. Russian.

[Analysis of the MTHFR gene linkage disequilibrium structure and association of polymorphic gene variants with coronary atherosclerosis].

Trifonova EA, Spiridonova MG, Gabidulina TV, Urnov FD, Puzyrev VP, Stepanov VA.

Genetika. 2012 Oct;48(10):1207-20. Russian.

The Genetic Diversity and Structure of Linkage Disequilibrium of the MTHFR Gene in Populations of Northern Eurasia.

Trifonova EA, Eremina ER, Urnov FD, Stepanov VA.

Acta Naturae. 2012 Jan;4(1):53-69.

[Genetic diversity of Khakassian gene pool: subethnic differensiation and the structure of Y-chromosome haplogroups,].

Khar'kov VN, Khamina KV, Medvedeva OF, Shtygasheva OV, Stepanov VA.

Mol Biol (Mosk). 2011 May-Jun;45(3):446-58. Russian.

[Genetic diversity of X-chromosome in populations of aboriginal Siberian ethnic groups: linkage disequilibrium structure and haplotype philogeography of ZFX locus].

Khitrinskaia IIu, Khar'kov VN, Stepanov VA.

Mol Biol (Mosk). 2010 Sep-Oct;44(5):804-15. Russian.

Genomes, populations and diseases: ethnic genomics and personalized medicine.

Stepanov VA.

Acta Naturae. 2010 Oct;2(4):15-30.

[Analysis of clusterin gene (CLU/APOJ) polymorphism in Alzheimer's disease patients and in normal cohorts from Russian populations].

Golenkina SA, Gol'tsov AIu, Kuznetsova IL, Grigorenko AP, Andreeva TV, Reshetov DA, Kunizheva SS, Shagam LI, Morozova IIu, Goldenkova-Pavlova IV, Shimshilashvili Kh, Viacheslavova AO, Faskhutdinova G, Gareeva AÉ, Zaĭnullina AG, Khusnutdinova ÉK, Puzyrev VP, Stepanov VA, Kolotvin AV, Samokhodskaia LM, Selezneva ND, Gavrilova SI, Rogaev EI.

Mol Biol (Mosk). 2010 Jul-Aug;44(4):620-6. Russian.

Genetic variability of 15 autosomal STR loci in Russian populations.

Stepanov VA, Melnikov AV, Lash-Zavada AY, Kharkov VN, Borinskaya SA, Tyazhelova TV, Zhukova OV, Schneider YV, Shil'nikova IN, Puzyrev VP, Rybakova AA, Yankovsky NK.

Leg Med (Tokyo). 2010 Sep;12(5):256-8. doi: 10.1016/j.legalmed.2010.05.006. Epub 2010 Jul 13.

[Comparative characteristics of the gene pool of Teleuts inferred from Y-chromosomal marker data].

Khar'kov VN, Medvedeva OF, Luzina FA, Kolbasko AV, Gafarov NI, Puzyrev VP, Stepanov VA.

Genetika. 2009 Aug;45(8):1132-42. Russian.

Short oligonucleotide tandem ligation assay for genotyping of single-nucleotide polymorphisms in Y chromosome.

Skobeltsyna LM, Pyshnyi DV, Ivanova EM, Stepanov VA, Puzyrev VP, Dymshits GM, Kharkov VN, Zarytova VF.

Mol Biotechnol. 2010 May;45(1):1-8. doi: 10.1007/s12033-009-9208-2.

Refined geographic distribution of the oriental ALDH2*504Lys (nee 487Lys) variant.

Li H, Borinskaya S, Yoshimura K, Kal'ina N, Marusin A, Stepanov VA, Qin Z, Khaliq S, Lee MY, Yang Y, Mohyuddin A, Gurwitz D, Mehdi SQ, Rogaev E, Jin L, Yankovsky NK, Kidd JR, Kidd KK.

Ann Hum Genet. 2009 May;73(Pt 3):335-45. doi: 10.1111/j.1469-1809.2009.00517.x.

[Genetic diversity and the structure of linkage disequilibrium in the methylenetetrahydrofolate reductase locus].

Trifonova EA, Spiridonova MG, Stepanov VA.

Genetika. 2008 Oct;44(10):1410-9. Russian.

[The origin of Yakuts: analysis of Y-chromosome haplotypes].

Khar'kov VN, Stepanov VA, Medvedev OF, Spiridonova MG, Maksimova NR, Nogovitsyna AN, Puzyrev VP.

Mol Biol (Mosk). 2008 Mar-Apr;42(2):226-37. Russian.

[The clinical-genealogic and molecular-genetic characteristics of oculopharyngeal muscular dystrophy in the Republic of Sakha (Yakutia)].

Maksimova NR, Nikolaeva IA, Korotkov MN, Ikeuchi T, Onodera O, Nishizava M, Stepanova SK, Kurtanov KhA, Sukhomiasova AL, Nogovitsyna AN, Gurinova EE, Stepanov VA, Puzyrev VP.

Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(6):52-60. Russian.

Evidence for gap anisotropy in CaC6 from directional point-contact spectroscopy.

Gonnelli RS, Daghero D, Delaude D, Tortello M, Ummarino GA, Stepanov VA, Kim JS, Kremer RK, Sanna A, Profeta G, Massidda S.

Phys Rev Lett. 2008 May 23;100(20):207004. Epub 2008 May 20.

[Polymorphism of human MDR1 gene in the Siberian and central Asian populations].

Pel's IaR, Marusin AV, Spiridonova MG, Stepanov VA.

Mol Biol (Mosk). 2007 Nov-Dec;41(6):982-8. Russian.

Beringian standstill and spread of Native American founders.

Tamm E, Kivisild T, Reidla M, Metspalu M, Smith DG, Mulligan CJ, Bravi CM, Rickards O, Martinez-Labarga C, Khusnutdinova EK, Fedorova SA, Golubenko MV, Stepanov VA, Gubina MA, Zhadanov SI, Ossipova LP, Damba L, Voevoda MI, Dipierri JE, Villems R, Malhi RS.

PLoS One. 2007 Sep 5;2(9):e829.

[Gene pool differences between northern and southern Altaians inferred from the data on Y-chromosomal haplogroups].

Khar'kov VN, Stepanov VA, Medvedeva OF, Spiridonova MG, Voevoda MI, Tadinova VN, Puzyrev VP.

Genetika. 2007 May;43(5):675-87. Russian.

[Association analysis of gene polymorphism in alcohol metabolizing enzymes with risk for coronary atherosclerosis].

Marusin AV, Stepanov VA, Spiridonova MG, Khar'kov VA, Pel's IaR, Puzyrev VP.

Genetika. 2007 Mar;43(3):409-16. Russian.

Plasma antioxidant activity and chromosome aberrations in humans exposed to long-term low-dose gamma-irradiation.

Marusin AV, Popova NA, Salyukov VB, Stepanov VA, Nazarenko SA.

Bull Exp Biol Med. 2005 Jun;139(6):703-5.

[Frequencies of Y chromosome binary haplogroups in Belarussians].

Khar'kov VN, Stepanov VA, Feshchenko SP, Borinskaia SA, Iankovskiĭ NK, Puzyrev VP.

Genetika. 2005 Aug;41(8):1132-6. Russian.

[Alcohol dehydrogenases ADH1B and ADH7 gene polymorphism in Russian population from the Siberian region].

Marusin AV, Stepanov VA, Spiridonova MG, Puzyrev VP.

Mol Biol (Mosk). 2004 Jul-Aug;38(4):625-31. Russian.

[Population study of frequency of methylenetetrahydrofolate reductase C677T gene polymorphism in Yakutia].

Spiridonova MG, Stepanov VA, Maksimova NR, Puzyrev VP.

Genetika. 2004 May;40(5):704-8. Russian.

[Structure of the gene pool of eastern Ukrainians from Y-chromosome haplogroups].

Khar'kov VN, Stepanov VA, Borinskaia SA, Kozhekbaeva ZhM, Gusar VA, Grechanina EIa, Puzyrev VP, Khusnutdinova EK, Iankovskiĭ NK.

[Genomic study of the hereditary pathology and genetic diversity of the Siberian population].

Puzyrev VP, Stepanov VA, Nazarenko SA.

Mol Biol (Mosk). 2004 Jan-Feb;38(1):129-38. Russian.

[Ethnic genomics and hereditary fundamentals of prevalent diseases].

Stepanov VA.

Vestn Ross Akad Med Nauk. 2003;(12):85-8. Russian. No abstract available.

[Comparative phylogenetic study of native north Eurasian populations from a panel of autosomal microsatellite loci].

Stepanov VA, Spiridonova MG, Puzyrev VP.

Genetika. 2003 Nov;39(11):1564-72. Russian.

[Genetic differentiation of residents of Central Asia from autosomal marker data].

Khitrinskaia IIu, Stepanov VA, Puzyrev VP, Spiridonova MG, Voevoda MI.

Genetika. 2003 Oct;39(10):1389-97. Russian.

[Analysis of genetic diversity of population of Northern Eurasia from autosomal microsatellite loci].

Stepanov VA, Spiridonova MG, Tadinova VN, Puzyrev VP.

Genetika. 2003 Oct;39(10):1381-8. Russian.

[MtDNA and Y-chromosome lineages in the Yakut population].

Puzyrev VP, Stepanov VA, Golubenko MV, Puzyrev KV, Maksimova NR, Khar'kov VN, Spiridonova MG, Nogovitsyna AN.

Genetika. 2003 Jul;39(7):975-81. Russian.

[Alu repeats in the human genome].

Khitrinskaia IIu, Stepanov VA, Puzyrev VP.

Mol Biol (Mosk). 2003 May-Jun;37(3):382-91. Review. Russian.

[Genetic peculiarity of the yakut population from the autosomal loci data].

Khitrinskaia IIu, Stepanov VA, Puzyrev VP, Spiridonova MG, Puzyrev KV, Maksimova NR, Nogovitsyna AN.

Mol Biol (Mosk). 2003 Mar-Apr;37(2):234-9. Russian.

[Analysis of gene complexes predisposing to coronary atherosclerosis].

Spiridonova MG, Stepanov VA, Puzyrev VP, Karpov RS.

Genetika. 2002 Mar;38(3):383-92. Russian.

[Analysis of Alu-polymorphism in Buryat populations].

Khitrinskaia IIu, Stepanov VA, Pyzyrev VP.

Genetika. 2001 Nov;37(11):1553-8. Russian.

The estimation of gametic disequilibrium between DNA markers in candidate genes for coronary artery disease (CAD) and the associations of gene complexes with risk factors for CAD.

Spiridonova MG, Stepanov VA, Puzyrev VP, Karpov RS.

Int J Circumpolar Health. 2001 Apr;60(2):222-7.

[Genetic differentiation of the Tuva population with respect to the Alu insertions].

Stepanov VA, Khitrinskaia IIu, Puzyrev VP.

Genetika. 2001 Apr;37(4):563-9. Russian.

[Role of polymorphic variants of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene in the pathogenesis of cardiovascular diseases].

Spiridonova MG, Stepanov VA, Puzyrev VP.

Klin Med (Mosk). 2001;79(2):10-6. Review. Russian. No abstract available.

[Haplotype of Y-chromosomes in the Central Asia population].

Stepanov VA, Khar'kov VN, Soltobaeva ZhO, Puzyrev VP, Stegniĭ VN.

Genetika. 2001 Feb;37(2):256-9. Russian.

[Connection of the polymorphic variant T174M angiotensinogen gene with coronary atherosclerosis in the Tomsk population].

Spiridonova MG, Stepanov VA, Puzyrev VP, Kosiankova TV, Karpov RS.

Mol Biol (Mosk). 2001 Jan-Feb;35(1):14-8. Russian.

[Relationship between polymorphism C677T of the methylene tetrahydrofolate reductase gene with clinical symptoms of coronary atherosclerosis].

Spiridonova MG, Stepanov VA, Pyzyrev VP, Karpov RS.

Genetika. 2000 Sep;36(9):1269-73. Russian.

[Microsatellite haplotypes of the Y-chromosome demonstrate the absence of subdivisions and presence of several components in the Tuvinian male gene pool].

Stepanov VA, Puzyrev VP.

Genetika. 2000 Mar;36(3):377-84. Russian.

[Analysis of allele frequency of seven microsatellite loci of Y chromosome in three Tuva populations].

Stepanov VA, Puzyrev VP.

Genetika. 2000 Feb;36(2):241-8. Russian.

[Haplotypes of two diallelic Y chromosome loci in the indigenous and migrant populations of Siberia].

Stepanov VA, Puzyrev VP.

Genetika. 2000 Jan;36(1):87-92. Russian.

[Analysis of the Alu insertion polymorphism in urban and rural populations of Siberia].

Stepanov VA, Puzyrev VP, Spiridonova MG, Khitrinskaia IIu.

Genetika. 1999 Aug;35(8):1138-43. Russian.

[Polymorphism of angiotensin-converting enzyme and endothelial nitric oxide synthase genes in people with arterial hypertension, left ventricular hypertrophy, and hypertrophic cardiomyopathy].

Stepanov VA, Puzyrev KV, Spiridonova MG, Pavliukova EN, Puzyrev VP, Karpov RS.

Genetika. 1998 Nov;34(11):1578-81. Russian.

[Role of apolipoprotein B and lipoprotein lipase gene polymorphism in variability of serum lipid levels].

Stepanov VA, Puzyrev VP, Tsymbaliuk IV.

Vestn Ross Akad Med Nauk. 1998;(10):3-6. Russian.

[Genomic studies of hereditary cardiomyopathies].

Stepanov VA, Puzyrev KV.

Genetika. 1998 Mar;34(3):325-34. Review. Russian.

Genetic markers in coronary artery disease in a Russian population.

Stepanov VA, Puzyrev VP, Karpov RS, Kutmin AI.

Hum Biol. 1998 Feb;70(1):47-57.

[Restriction polymorphism of the APOB locus in residents of the city of Tomsk].

Stepanov VA, Puzyrev VP, Marusin AV.

Genetika. 1997 Jul;33(7):1001-4. Russian.

[Interrelationship between structural variants of the apolipoprotein B and ischemic heart disease and plasma lipid levels].

Stepanov VA, Puzyrev VP, Lemza SV, Karpov RS, Fedorov AIu.

Genetika. 1995 Mar;31(3):405-9. Russian.

Apolipoprotein B gene polymorphism in a Russian population.

Stepanov VA, Puzyrev VP.

Hum Biol. 1994 Jun;66(3):527-31.

PvuII restriction fragment length polymorphism of lipoprotein lipase in Russians.

Stepanov VA, Lemza SV.

Hum Hered. 1993 Nov-Dec;43(6):388-90.

[PvuII restriction fragment length polymorphism at the lipoprotein lipase gene].

Stepanov VA, Lemza SV, Puzyrev VP.

Genetika. 1993 Jun;29(6):1050-2. Russian.