Personalities

Evgeny L. Choynzonov

Evgeny L. Choynzonov, M.D., Dr. Sci. (Med.), Professor, Full Member of the Russian Academy of Sciences, Director of Cancer Research Institute of Tomsk National Research Medical Center, Head of the Department of Head and Neck Tumors of Cancer Research Institute, Head of Oncology Department of Siberian State Medical University.

Contact information

e-mail: choynzonov@tnimc.ru tel.: 8 (3822) 51-10-39 fax: 8 (3822) 41-80-87

Brief Biography

After graduating from the Faculty of General Medicine of Tomsk Medical Institute, Evgeny L. Choynzonov worked as a surgeon and, later, he held the positions of junior, senior and leading research scientist in the Branch of the All-Union Oncology Research Center of the Academy of Medical Sciences of the USSR.
In 1984, he defended his doctoral thesis titled “Treatment of patients with oral cavity cancer and its influence on immunity system” for an academic degree of Candidate of Sciences (equivalent of Ph.D.). In 1995, he defended his doctoral thesis titled “Cancer of the upper respiratory and digestive tracts” for an academic degree of Doctor of Medical Sciences. Since 2004, he has been a Head of the Department of Head and Neck Tumors.
In 2002, Evgeny L. Choynzonov was awarded the rank of Professor. In 2005, he was elected a Corresponding Member of the Russian Academy of Medical Sciences in discipline of Oncology, and in 2011, a Member of the Russian Academy of Medical Sciences. From 2002 to 2016, Prof. Choynzonov was appointed as Director of Cancer Research Institute.
Since July 1, 2016, Evgeny L. Choynzonov has been a Director of Tomsk NRMC. Since December, 2018, Evgeny L.Choynzonov has been a Director of Cancer Research Institute of Tomsk National Research Medical Center.

Research Interests

The main research interests of Evgeny L. Choynzonov focus on the development of novel approaches to surgical treatment of head and neck cancer patients using implants from the porous titanium-nickelid, microsurgical autografting, organ-preserving and reconstructive surgeries in combination with intraoperative radiation therapy and neutron therapy. Evgeny L. Choynzonov made substantial contribution to the study of mechanisms of carcinogenesis and identification of molecular markers associated with high risk of cancer progression. He developed and implemented into clinical practice a number of original surgeries, the most effective, safe, and cost-effective approaches for predictive, preventive and personalized cancer therapy. The current methods of vocal function recovery for laryngectomized patients using biological feedback based on a mathematical model were developed.
Under his direct supervision, new data on the mechanisms of the development of resistance of tumor cells to free radical damage were obtained, and clinical-epidemiological characteristics of primary multiple head and neck tumors were revealed.
Evgeny L. Choynzonov is an author of more than 800 scientific works including 19 books and 37 authorship certificates and patents. Under supervision of Evgeny L. Choynzonov, 10 dissertations for a degree of Doctor of Sciences and 19 dissertations for a Ph.D. degree have been defended.
Being a worldwide renowned Russian oncologist, Evgeny L. Choymzonov promotes achievements of his team abroad and regularly gives talks at symposia, conferences and meetings.
Evgeny L. Choynzonov is an Editor-in-Chief of the Siberian Journal of Oncology. He is a member of editorial boards of the following Russian journals: Problems in Oncology, Surgical Oncology, Head and Neck Tumors, Siberian Research Medical Journal, Sarcomas of Bones, Soft Tissues and Skin, Head and Neck. He is a member of the International peer-reviewed journal: Eurasian Journal of Oncology.

Awards and Grant

Evgeny L. Choynzonov is a member of the International Federation of Head and Neck Oncologic Societies (IFHNOS, USA) and Eurasian community of specialists in head and neck tumors (Belarus).
Evgeny L. Choynzonov is a chairman of Siberian Association of Oncologists, Tomsk Regional Society of Oncologists, Coordinating Board of Tomsk Research Medical Center, Public Chamber of Tomsk region. He is a Chief Oncologist of Siberian Federal District
Evgeny L. Choynzonov is a member of Association of Russian Oncologists, Presidium of the Russian Association of Oncologists, Association of Directors of Oncology, Radiology and Roentgenology Centers of CIS countries, Working Group on National Project “Health”.
Research projects conducted by Evgeny L. Choynzonov and his colleagues received financial support in the framework of the federal target programs of the Russian Federation, the Ministry of Health of the Russian Federation, grants of the Russian Foundation for Basic Research and the Russian Science Foundation.
For his excellence, long-standing and fruitful work, Evgeny L. Choynzonov has been awarded with the government and community awards: Honorary Diplomas of Academy of Medical Sciences, Siberian Branch of the Academy of Medical Sciences, Tomsk Oblast Administration, Achievement Medal and Commemorative Badge of the Russian Association of Oncologists for his contribution to the development of professional relationships between oncologists of CIS & Eurasian countries. He is a laureate of Tomsk Region Award in the Field of Science and Healthcare. He was recorded in the Book of Honor of Tomsk region.

Main Publications

1. Ponomaryova A.A., Morozkin E.S., Rykova E.Y., Zaporozhchenko I.A., Skvortsova T.E., Dobrodeev А.Y, Zavyalov A.A., Tuzikov S.A. Vlassov N.V. Cherdyntseva N.V., Laktionov P.P., Choinzonov E.L. (2016). Dynamic changes in circulating mirna levels in response to antitumor therapy of lung cancer. Exp Lung Res. V.42(2). 95-102.


2. Gervas P., Ivanova A., Vasiliev N., Ananina O., Zharkova O., Rogovieva O., Verzhbitskaya N., Didichuk I., Cheremisina O., Popova N., Goldberg V., Cherdyntsev E., Choynzonov E., Cherdyntseva N. (2015). Frequency of EGFR Mutations in Non-small Cell Lung Cancer Patients: Screening Data from West Siberia. Asian Pac J Cancer Prev. V.16(2). 689-92. DOI:http://dx.doi.org/10.7314/APJCP.2015.16.2.689


3. Denisov E.V., Gerashchenko T.S., Zavyalova M.V., Manskikh V.N., Choinzonov E.L., Cherdyntseva N.V., Perelmuter V.M. (2016). Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma. Current Clinical Oncology (edited by Maurie Markman), Springer International Publishing. 211-228.


4. Babyshkina N., Vtorushin S., Zavyalova M., Patalyak S., Dronova T., Litviakov N., Slonimskaya E., Kzhyshkowska J., Cherdyntseva N., Choynzonov E. (2016). The distribution pattern of ERα expression, ESR1 genetic variation and expression of growth factor receptors: association with breast cancer prognosis in Russian patients treated with adjuvant tamoxifen. Clinical and Experimental Medicine. DOI: 10.1007/s10238-016-0428-z.


5. Tverdokhlebov S.I., Choinzonov E.L., Kolokolova O.V. Cherdyntseva N.V. (2016). Comparison of titanium mesh implants with PLA-hydroxyapatite coatings for maxillofacial cancer reconstruction. AIP Conf. Proc. V.1760. 020067. http://dx.doi.org/10.1063/1.4960286.


6. Balatskaya L.N.,Choinzonov E.L., Chizevskaya S.Yu., Kostyuchenko E.U., Meshcheryakov R.V. (2013). Software for assessing voice quality in rehabilitation of patients after surgical treatment of cancer of oral cavity, oropharynx and upper jaw. Lecture Notes in Computer Science. V.8113 LNAI. 294-301.


7. Muhamedov M.R., Kulbakin D.E., Gunther V.E., Choynzonov E.L. (2015). Sparing surgery with the use of TiNi-based endografts in larynx cancer patients. Journal of Surgical Oncology. V.111. 231-236. DOI 10.1002/jso.23779.


8. Denisov E.V., Sukhanovskaya T.V., Dultseva T.S., Malinovskaya E.A., Litviakov N.V., Slonimskaya E.M., Choinzonov E.L., Cherdyntseva N.V. (2011). Coordination of TP53 Abnormalities in Breast Cancer: Data from Analysis of TP53 Polymorphisms, Loss of Heterozygosity, Methylation, and Mutations. Genet Test Mol Biomarkers. V.15(12). 901-907.


9. Spirina L.V., Kondakova I.V., Choynzonov E.L., Chigevskaya S.Y., Shishkin D.A., Kulbakin D.Y. (2013). Expression of vascular endothelial growth factor and transcription factors HIF-1, NF-kB expression in squamous cell carcinoma of head and neck; association with proteasome and calpain activities. J Cancer Res Clin Oncol. V.139. 625–633. DOI 10.1007/s00432-012-1366-0.


10. Kaigorodova E.V., Zavyalova M.V., Bychkov V.A., Perelmuter V.M, Choynzonov E.L. (2016). Functional state of the Hsp27 chaperone as a molecular marker of an unfavorable course of larynx cancer. Cancer Biomark. V.17(2). 145-53. doi: 10.3233/CBM-160625.,/li>
    
11. Litviakov N.V., Cherdyntseva N.V., Tsyganov M.M., Slonimskaya Е.М., Ibragimova M.K., Kazantseva P.V., Kzhyshkowska J., Choinzonov E.L. (2016) Deletions of multidrug resistance gene loci in breast cancer leads to the down-regulation of its expression and predict tumor response to neoadjuvant chemotherapy. Oncotarget. V.7(7). 7829-7841. doi: 10.18632/oncotarget.6953.


12. Zavyalova M., Vtorushin S., Telegina N., Krakhmal N., Savelieva O., Tashireva L., Bragina O., Denisov E., Kaigorodova E., Slonimskaya E., Choynzonov E., Perelmuter V. (2016). Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes. Exp Oncol. V.38(2). 122–127.


13. Chernov V.I., Zelchan R.V., Titskaya А.А., Sinilkin I.G., Choynzonov Е.L. (2013). Single photon emission computed tomography with с 99m TI-chloride in diagnosis and assessment of chemotherapy efficacy of primary and recurrentlaryngeal and laryngopharyngeal carcinomas. Molecular Medicine. V.4. 26-30.


14. Zelchan R.V., Chernov V.I., Titskaya А.А., Sinilkin I.G., Choynzonov Е.L. (2012). Nuclear medicine imaging techniques in the diagnosis and assessment of response of primary and recurrent laryngeal cancer to chemotherapy. Physics. V.55(2). 216-222.


15. Gribova О.V., Musabaeva L.I., Choynzonov Е.L., Novikov V.A. Lisin V.A. (2015). Fast neutrons in the treatment of head and neck cancer. Problems in Oncology. V.61(1). 149-153.


16. Melnikov A.A., Vasilyev S.A. , Musabaeva L.I. , Velikaya V.V., Gribova O.V., Startseva Zh.A., Urazova L.N., Lebedev I.N., Choynzonov E.L. (2012). Cytogenetic effects of neutron therapy in patients with parotid gland tumors and relapse of breast cancer. Exp Oncol. V.34(4). 354–357.


17. Choynzonov Е.L., Musabaeva L.I., Avdeenko M.V., Gribova O.V. (2010). Combined and radiation therapy for parotid cancer. Russian Journal of Oncology. V.4. 25-28.


18. Kakurina, G.V., Kondakova, I.V., Cheremisina, O.V., Shishkin, D.A., Choinzonov, E.L. Adenylyl Cyclase-Associated Protein 1 in the Development of Head and Neck Squamous Cell Carcinomas // Bulletin of Experimental Biology and Medicine. – 2016. - pp. 1-3. Article in Press. DOI: 10.1007/s10517-016-3252-2/ -


19. Dygai, A.M., Skurikhin, E.G., Pershina, O.V., Ermakova, N.N., Krupin, V.A., Ermolaeva, L.A., Stakheeva, M.N., Choinzonov, E.L., Goldberg, V.E., Reikhart, D.V., Ellinidi, V.N., Kravtsov, V.Y. Role of Hematopoietic Stem Cells in Inflammation of the Pancreas during Diabetes Mellitus // Bulletin of Experimental Biology and Medicine. – 2016. - pp. 1-6. Article in Press. DOI: 10.1007/s10517-016-3200-1.


20. Nikolai V. Litviakov, Nadezhda V. Cherdyntseva, Matvey M. Tsyganov, Еlena М. Slonimskaya, Marina K. Ibragimova, Polina V. Kazantseva, Julia Kzhyshkowska, Eugeniy L. Choinzonov Deletions of multidrug resistance gene loci in breast cancer leads to the down-regulation of its expression and predict tumor response to neoadjuvant chemotherapy // Oncotarget, Advance Publications 2016


21. Babyshkina, N., Vtorushin, S., Zavyalova, M., Patalyak, S., Dronova, T., Litviakov, N., Slonimskaya, E., Kzhyshkowska, J., Cherdyntseva, N., Choynzonov, E. The distribution pattern of ERα expression, ESR1 genetic variation and expression of growth factor receptors: association with breast cancer prognosis in Russian patients treated with adjuvant tamoxifen // Clinical and Experimental Medicine. – 2016. - pp. 1-11. Article in Press. DOI: 10.1007/s10238-016-0428-z


22. Kaigorodova EV, Zavyalova MV, Bychkov VA, Perelmuter VM, Choynzonov EL. Functional state of the Hsp27 chaperone as a molecular marker of an unfavorable course of larynx cancer // Cancer Biomark. 2016 Jun 24;17(2):145-53. doi: 10.3233/CBM-160625


23. Zavyalova M., Vtorushin S.V., Telegina N., Krakhmal N., Savelieva O., Tashireva L., Bragina O., Denisov E.V., Kaigorodova E.V., Slonimskaya E., Choynzonov E.L., Perelmuter V.M. Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes // Exp Oncol 2016 38, 2, 122–127.


24. Gervas P, Ivanova A, Vasiliev N, Ananina O, Zharkova O, Rogovieva O, Verzhbitskaya N, Didichuk I, Cheremisina O, Popova N, Goldberg V, Cherdyntsev E, Choynzonov E, Cherdyntseva N. Frequency of EGFR Mutations in Non-small Cell Lung Cancer Patients: Screening Data from West Siberia. // Asian Pac J Cancer Prev. 2015;16(2):689-92. DOI:http://dx.doi.org/10.7314/APJCP.2015.16.2.689. - Режим доступа: a href="http://elibrary.ru/item.asp?id=24019482" target="_blank">http://elibrary.ru/item.asp?id=24019482


25. Marat Muhamedov, Denis Kulbakin, Victor Gunther, Evgeniy Choynzonov, Timofey Chekalkin, Valentina Hodorenko Sparing surgery with the use of tini-based endografts in larynx cancer patients // Journal of Surgical Oncology. – 2015.-111. – P. 231-236 DOI 10.1002/jso.23779.


26. Balatskaya L.N., Choinzonov E.L., Chizevskaya S.Yu., Kostyuchenko E.U., Meshcheryakov R.V. Software for assessing voice quality in rehabilitation of patients after surgical treatment of cancer of oral cavity, oropharynx and upper jaw // Lecture Notes in Computer Science. - 2013. - Т. 8113 LNAI. С. 294-301.


27. Cherdyntseva N. V., Denisov E. V., Litviakov N. V., Maksimov V. N. Malinovskaya E. A., Babyshkina N. N., E. M. Slonimskaya, Voevoda M. I., E. L. Choinzonov Crosstalk Between the FGFR2 and TP53 Genes in Breast Cancer: Data from an Association Study and Epistatic Interaction Analysis // DNA and Cell Biology. – DNA Cell Biol. 2012 Mar;31(3):306-16. doi: 10.1089/dna.2011.1351. Epub 2011 Aug 12 - http://elibrary.ru/item.asp?id=17979809


28. Cherdyntseva N. V., Gervas P. A., Litvyakov N. V., Stakcheeva M. N., Ponomaryeva A.A., Dobrodeev A. Yu., Denisov E. V., Belyavskaya V. A., Choinzonov E. L. Age-related function of tumor suppressor gene TP53: contribution to cancer risk and progression // Experimental oncology. - 2010. – № 3. – C. 205-208. - http://exp-oncology.com.ua/wp/wp-content/uploads/m