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“Alotech, 99mTc” - a new domestic radioactive pharmaceutical for imaging of sentinel lymph nodes

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  • “Alotech, 99mTc” - a new domestic radioactive pharmaceutical for imaging of sentinel lymph nodes

In recent years radionuclide research methods have proven themselves to detect the so-called sentinel lymph nodes (SLN) - the first nodes into which a malignant tumor drains. These nodes filtering afferent lymph become a trap for malignant cells, so the biopsy of SLN (with the following histological examination) is the objective diagnostic criteria of the spread of malignant process. It is supposed that if the SLN are not affected by a metastatic process, all the other regional nodes remain intact. The world's nuclear medicine has several radiopharmaceuticals (RPs) for detecting SLN. The main drawback of RPs is low accumulation in the SLN (1,5-2% of the administered dose) and their redistribution to the level II and III lymph nodes; it decreases the specificity of the study. Considering the lack of SLN imaging drugs registered in the Russian Federation, the scientists of Cancer Research Institute of Tomsk NRMC and Tomsk Polytechnic University have developed the original RP based on technetium 99-m labelled gamma-oxide of aluminium (Alotech, 99mТс). The drug was developed as part of the “Preclinical studies of a new lymphotropic radioactive pharmaceutical based based on technetium 99-m labelled gamma-oxide of aluminium” project No. 16.N08.12.1011 (the Federal Target Program “Development of pharmaceutical and medical industry of the Russian Federation for the period up to 2020 and beyond”). The preclinical and clinical trials of the RP have shown that the study drug is low toxic and accumulates in the lymph nodes much more actively than its foreign analogues. The practical application of this drug facilitates the intraoperative detection of SLN. The “Method of obtaining reagent for preparation of technetium 99-m labelled nanocolloid based on gamma-oxide of aluminium” patent entered the top 100 of best inventions in Russia in 2014 (Order of the Federal Service for Intellectual Property No. 50 dated April 24, 2015).