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Development of new-generation coronary stent

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  • Development of new-generation coronary stent

The project aims at the development and elaboration of the technology and infrastructure of producing Russian new-generation metallic stent with biodegradable polymer coating containing chemically modified carbon nanomaterial selectively interacting with strictly defined fractions of the lipid spectrum of bioorganic media including atherosclerotic formations on the vascular walls, destroying them, and making them accessible for further metabolizing.

The product will allow solving the following problems of currently available stents:

  • restenosis of coronary arteries caused by the endothelial growth and atherosclerotic plaque in the area of placed coronary stents.
  • reducing the risk of myocardial infarction onset and sudden cardiac death

Currently, the project is at the R&D stage. In 2015 and in the beginning of 2016, we had completed the work stages, which received finding from the Foundation for Assistance to Small Innovative Enterprises in Science and Technology and, as a result, initiated creation of new-generation stent.

The next stage of work was «The study of the effects of biodegradable material containing nanoparticles, used for vascular stent coating, on the morphofunctional state of biological tissues».

In 2018, under support of Skolkovo Foundation, we performed works on «Research tests to characterize local effects of the object — medical product, namely — samples of coronary stent with biodegradable coating with different concentrations of chemically modified nanomaterial». The results of the study allowed to elucidate the optimal concentration of nanomaterial present in the composition of the biodegradable coating (3%).

The next step of the works consists in the assessment of morphofunctional changes in the surrounding tissues of the experimental animals after the implantation of the samples of the vascular stent with 3%-content of carbon nanocomposites in the long-term postoperative period.